规格

价格

库存

数量

5 μg

¥ 343

2-4周

10 μg

¥ 550

2-4周

20 μg

¥ 878

2-4周

50 μg

¥ 1,670

2-4周

100 μg

¥ 3,120

2-4周

200 μg

¥ 5,890

2-4周

500 μg

¥ 13,700

2-4周

1 mg

¥ 20,500

2-4周

生物活性

产品描述	TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation.
生物活性	Immobilized Human GITR-mFc at 5μg/ml (100 μl/well) can bind Cynomolgus GITR Ligand-His . The ED50 of Recombinant Cynomolgus GITR Ligand-His is 632 ng/ml. (Regularly tested)
研究背景	TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation.
种属	Cynomolgus
表达系统	HEK293 Cells
标签	C-6xHis
蛋白编号	A0A2K5UCD9
氨基酸序列	Glu74-Ser199
蛋白构建	Glu74-Ser199
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名	Tumor necrosis factor ligand superfamily member 18, TNFSF18, TL6, Glucocorticoid-induced TNF-related ligand, GITRL, AITRL, Activation-inducible TNF-related ligand
内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.

化学信息

分子量	15-20 KDa (reducing condition)

储存&溶解度

运输方式

In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.

存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

实际储存温度请以COA为准

GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His)

GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His)

产品介绍

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