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GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His)

GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His)

产品编号 TMPJ-00432
别名: GITRL, TNFSF18, Activation-inducible TNF-related ligand, AITRL, Glucocorticoid-induced TNF-related ligand, TL6, Tumor necrosis factor ligand superfamily member 18

TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation.

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GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His)
规格 价格/CNY 货期 数量
10 μg ¥ 550 5日内发货
50 μg ¥ 1,670 5日内发货
500 μg ¥ 13,700 5日内发货
1 mg ¥ 20,500 5日内发货
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产品目录号及名称: GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His) (TMPJ-00432)
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生物活性
技术参数
产品性质
生物活性 Immobilized Human GITR-mFc at 5μg/ml (100 μl/well) can bind Cynomolgus GITR Ligand-His . The ED50 of Recombinant Cynomolgus GITR Ligand-His  is 632 ng/ml. (Regularly tested)
产品描述 TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation.
种属 Cynomolgus
表达系统 HEK293 Cells
标签 C-6xHis
蛋白编号 A0A2K5UCD9
别名 GITRL, TNFSF18, Activation-inducible TNF-related ligand, AITRL, Glucocorticoid-induced TNF-related ligand, TL6, Tumor necrosis factor ligand superfamily member 18
氨基酸序列 Glu74-Ser199
蛋白构建 Glu74-Ser199
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 15-20 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation.

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Keywords

GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His) TL 6 TL-6 GITRL TNFSF 18 TNFSF18 Activation-inducible TNF-related ligand TNFSF-18 AITRL Glucocorticoid-induced TNF-related ligand TL6 Tumor necrosis factor ligand superfamily member 18 recombinant recombinant-proteins proteins protein

 

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