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DR5/TRAIL R2 Protein, Human, Recombinant (His)

DR5/TRAIL R2 Protein, Human, Recombinant (His)

产品编号 TMPY-01185
别名: KILLER, TRICK2A, TRICK2, DR5, TRICKB, tumor necrosis factor receptor superfamily, member 10b, CD262, TRAIL-R2, TRICK2B, ZTNFR9, TRAILR2, KILLER/DR5

DR5/TRAIL R2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.7 kDa and the accession number is O14763-1.

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DR5/TRAIL R2 Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
100 μg ¥ 2,030 现货
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产品目录号及名称: DR5/TRAIL R2 Protein, Human, Recombinant (His) (TMPY-01185)
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生物活性
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参考文献
生物活性 Measured by its binding ability in a functional ELISA. Immobilized human TNFRSF10B at 10 μg/ml (100 μl/well) can bind biotinylated TNFSF10 with a linear range of 0.625-20 ng/ml.
产品描述 DR5/TRAIL R2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.7 kDa and the accession number is O14763-1.
种属 Human
表达系统 HEK293 Cells
标签 C-His
蛋白编号 O14763-1
别名 KILLER, TRICK2A, TRICK2, DR5, TRICKB, tumor necrosis factor receptor superfamily, member 10b, CD262, TRAIL-R2, TRICK2B, ZTNFR9, TRAILR2, KILLER/DR5
蛋白构建 The Human TNFRSF10B (NP_003833.4) extracellular domain (Met1-Glu182) was expressed with a polyhistidine tag at the C-terminus.
蛋白纯度 > 95 % as determined by SDS-PAGE

TargetMol

分子量 15.7 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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Keywords

DR5/TRAIL R2 Protein, Human, Recombinant (His) KILLER DR 5 TRICK2A CD 262 TRAILR-2 DR-5 TRICK2 DR5 TRICKB ZTNFR-9 CD-262 tumor necrosis factor receptor superfamily, member 10b TRICK 2 CD262 TRAIL-R2 TRAILR 2 ZTNFR 9 TRICK-2 TRICK2B ZTNFR9 TRAILR2 KILLER/DR5 recombinant recombinant-proteins proteins protein

 

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