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Anti-DR4/TRAIL R1 Antibody (3R561)
还可以产品编号 TMAY-00781
Anti-DR4/TRAIL R1 Antibody (3R561) 是一种 Rabbit 抗体，靶向 DR4/TRAIL R1。Anti-DR4/TRAIL R1 Antibody (3R561) 可用于 FCM。
Anti-DR4/TRAIL R1 Antibody (3R561)
Anti-DR4/TRAIL R1 Antibody (3R561)
还可以产品编号 TMAY-00781
Anti-DR4/TRAIL R1 Antibody (3R561) 是一种 Rabbit 抗体，靶向 DR4/TRAIL R1。Anti-DR4/TRAIL R1 Antibody (3R561) 可用于 FCM。
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抗原信息
| 产品描述 | Anti-DR4/TRAIL R1 Antibody (3R561) is a Rabbit antibody targeting DR4/TRAIL R1. Anti-DR4/TRAIL R1 Antibody (3R561) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 3R561 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human TNFRSF10A(CD261) on HeLa cells. Cells were stained with purified anti-Human TNFRSF10A(CD261) (Filled hisgram), then stained with a FITC-conjugated second step antibody. To demonstrate specificity of staining, the binding by Anti-DR4/TRAIL R1 Antibody was blocked by preincubation of the purified antibody with 20ug recombinant human TNFRSF10A(CD261) for 1 hour (Black solid line hisgram). |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human TRAIL R1 / CD261 / TNFRSF10A (rh TRAIL R1 / CD261 / TNFRSF10A; TMPY-01720; NP_003835.2; Met1-Asn239). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Tumor necrosis factor receptor superfamily, member 10a (TRAIL R1), also known as TRAIL receptor 1 (TRAIL R1) or CD261 antigen, is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R1/CD261/TNFRSF10A serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAIL R1 can promote the activation of NF-kappa-B. TRAIL R1/CD261/TNFRSF10A induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human TRAIL R1 / CD261 / TNFRSF10A Protein (TMPY-01720) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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