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Anti-TNFR2/CD120b/TNFR1B Antibody-APC (2D734)
还可以产品编号 TMAY-03123A
Anti-TNFR2/CD120b/TNFR1B Antibody-APC (2D734) 是一种 APC-conjugated Rabbit 抗体，靶向 TNFR2/CD120b/TNFR1B。Anti-TNFR2/CD120b/TNFR1B Antibody-APC (2D734) 可用于 FCM。
Anti-TNFR2/CD120b/TNFR1B Antibody-APC (2D734)
Anti-TNFR2/CD120b/TNFR1B Antibody-APC (2D734)
还可以产品编号 TMAY-03123A
Anti-TNFR2/CD120b/TNFR1B Antibody-APC (2D734) 是一种 APC-conjugated Rabbit 抗体，靶向 TNFR2/CD120b/TNFR1B。Anti-TNFR2/CD120b/TNFR1B Antibody-APC (2D734) 可用于 FCM。
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抗原信息
| 产品描述 | Anti-TNFR2/CD120b/TNFR1B Antibody-APC (2D734) is a APC-conjugated Rabbit antibody targeting TNFR2/CD120b/TNFR1B. Anti-TNFR2/CD120b/TNFR1B Antibody-APC (2D734) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 2D734 |
| 交叉反应 | Mouse |
| 验证活性 | Flow cytometric analysis of mouse TNFR2(TNFRSF1B) expression on L929 cells. L929 cells were stained with APC-conjugated anti-mouse TNFR2(TNFRSF1B). The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TNFR2 / CD120b / TNFRSF1B (rM TNFR2 / CD120b / TNFRSF1B; TMPY-01697; NP_035740.2; Met1-Gly258) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | APC |
| 其他可选修饰符 | Unconjugated/PE |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Mouse TNFR2 / CD120b / TNFRSF1B protein (TMPY-01697) |
| 抗原种属 | Mouse |
| 研究领域 | Neuroinflammation |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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