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354

抑制剂 & 化合物

53

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12218	NFAT Transcription Factor Regulator-1	IL Receptor	Immunology/Inflammation
	NFAT Transcription Factor Regulator-1 是 IL-2 合成的抑制剂，IC50 值为182 nM。
TP2291	signal transducer and activator of transcription 6 fragment	Others	Others
	The signal transducer and activator of transcription 6 fragments is a peptide with the sequence H2N-Ser-Tyr-Trp-Ser-Asp-Arg-Leu-Ile-Ile-OH, MW= 1152.3.
T8890	653-47 hydrochloride	Epigenetic Reader Domain	Chromatin/Epigenetic
	653-47 hydrochloride 是一种增强剂，能显著增强 666-15 的 cAMP 反应元件结合蛋白 (CREB) 抑制活性。它也是 CREB 抑制剂，IC50为 26.3 μM。
T22062	CCG-100602	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	CCG-100602 是心肌蛋白相关转录因子 A/血清反应因子信号转导的特异性抑制剂。它抑制 PC-3 前列腺癌细胞中 RhoA/C 介导的、SRF 驱动的荧光素酶表达，IC50为 9.8 µM。
T40661	ML-60218	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	ML-60218 是广谱 RNA pol III 抑制剂，对酿酒酵母和人类的 IC50 分别为 32 和 27 μM。 ML-60218 会破坏已组装的病毒质并阻碍新病毒质的形成。
T14495	Baloxavir Baloxavir acid,S-033447	Influenza Virus	Microbiology/Virology
	Baloxavir (S-033447) 是衍生自前药 Baloxavir marboxil，是流感病毒聚合酶 PA 亚基的一流帽依赖性核酸内切酶抑制剂。它抑制病毒 RNA 的转录和复制，具有强大的抗病毒活性。
T22667	CID 5951923	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	CID 5951923 是 KLF5 转录因子的抑制剂，IC50 为 603 nM。
T21767	MS37452	Others; Histone Methyltransferase	Chromatin/Epigenetic; Others
	MS37452 是 CBX7 chromodomain 与 H3K27me3 结合的竞争性抑制剂，Ki 为 43 µM。它通过置换 CBX7 与前列腺癌细胞中INK4A/ARF 基因座的结合，抑制多梳抑制复合物靶基因 p16/CDKN2A 的转录。
T27029	cjoc42 cjoc 42,cjoc-42
	Cjoc42 是gankyrin 的抑制剂，以剂量依赖性方式抑制 gankyrin 活性。它可防止 p53 蛋白水平的降低。它恢复 p53 依赖性转录和对 DNA 损伤的敏感性。
T1767	BMH-21 BMH21	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	BMH-21 是一种小分子 DNA 嵌入剂，可结合核糖体 DNA 并抑制 RNA 聚合酶 I (Pol I) 转录，具有抗癌活性。
T4356	POL1-IN-1 Compound 3A	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	POL1-IN-1 (Compound 3A) 是一种RNA 聚合酶 1 POL1抑制剂，IC50值低于 0.5 uM。它能有效抑制A375恶性黑色素瘤细胞系中RNA 聚合酶I 的转录。
T13166	TK216	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	TK216 是一种口服有效的 E26 转录因子抑制剂，具有抗癌活性。它直接结合 EWS-FLI1 并抑制 EWS-FLI1 蛋白质相互作用，也可阻止 EWS-FLI1 与 RNA 解旋酶 A 的结合。
T22461	YKL-5-124	CDK	Cell Cycle/Checkpoint
	YKL-5-124 是选择性不可逆CDK7共价抑制剂，对CDK7和CDK7/Mat1/CycH 的IC50分别为 53.5 nM 和 9.7 nM。它诱导强烈的细胞周期停滞，并抑制 E2F 驱动的基因表达。它对 CDK7 的生化和细胞选择性优于 CDK12/13。它对CDK7的选择性比 CDK9 和 CDK2 高 100 倍以上。
T23820	BRD32048 BRD-32048,BRD 32048	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	BRD32048 可以与与 ETV1直接结合，KD 为 17.1 μM。BRD32048调节 ETV1 介导的转录活性和 ETV1 驱动的癌细胞侵袭。 BRD32048可以抑制 ETV1 乙酰化并促进其降解。
T12006	Metarrestin ML246	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Metarrestin (ML246) 是一种口服有效的选择性核仁周区室 (PNC) 抑制剂，可有效抑制转移。Metarrestin 破坏核仁结构并抑制 RNA 聚合酶 (Pol) I 转录，部分是通过与翻译延伸因子 eEF1A2 的相互作用。
T21807	INCA-6 Triptycene-1,4-quinone	Others	Others
	INCA-6 (Triptycene-1,4-quinone) 是细胞渗透性的 NFAT 抑制剂。INCA-6 通过特异性阻断 NFAT 底物靶向钙调神经磷酸酶位点，有效抑制calcineurin (CN)-NFAT 信号传导。
T10760	Ceramides Mixture 神经酰胺混合物,神经酰胺	Telomerase	DNA Damage/DNA Repair
	Ceramides Mixture 是表皮渗透屏障的主要脂质成分，参与生长抑制，细胞周期停滞和端粒酶活性的调节。它是一种内源性神经酰胺，由含羟基和非羟基脂肪酸的神经酰胺组成。
T7887	8-Hydroxyquinoline hemisulfate 8-羟基喹啉硫酸盐,Oxyquinoline sulfate	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	8-Hydroxyquinoline hemisulfate (Oxyquinoline sulfate) 是一种单质子双齿螯合剂，具有温和的抑菌、驱虫和杀螨作用。
T8972	FIT-039	Others; DNA/RNA Synthesis; CDK; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	FIT-039 是一种选择性和 ATP 竞争性的口服活性 CDK9 抑制剂，对CKD9/cyclin T1的IC50为 5.8 μM。它抑制HSV-1(IC50为 0.69 μM)，HSV-2，人腺病毒和人CMV 的复制。它可抑制耐药性HSV 和其他 DNA 病毒，是有前途的抗病毒药物。
T7764	CCG-222740	ROCK; Rho; Ras	Cell Cycle/Checkpoint; Cytoskeletal Signaling; GPCR/G Protein; MAPK; Stem Cells
	CCG-222740 是一种口服有效的选择性Rho/MRTF 途径抑制剂。它也是 α-平滑肌的肌动蛋白表达抑制剂，可减少皮肤纤维化并阻止黑色素瘤转移。
T20759	XRP44X XRP-44-X,XRP 44X,XRP-44X,XRP 44 X	Ras	GPCR/G Protein; MAPK
	XRP44X (XRP 44X) 是Ras 诱导的转录激活的抑制剂，IC50为 10 nM，通过 FGF-2 抑制 Ras-Erk-1/2 通路激活。它抑制Elk3。它还对微管有影响。
T5045	GSK4112 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate,SR6452	Autophagy	Autophagy
	GSK4112 (SR6452) 是一种 Rev-erbα 激动剂，EC50 为 0.4 μM。它也是一种用于核血红素受体 Rev-erbα 的细胞生物学的小分子化学探针。
T8841	IMT1 Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)	Others; DNA/RNA Synthesis; Mitochondrial Metabolism	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) 是一种非竞争特异性人类线粒体 RNA 聚合酶(POLRMT) 抑制剂，可引起 POLRMT 的构象变化，以剂量依赖性方式阻断底物结合和转录。它可降低脱氧核苷三磷酸水平和柠檬酸循环中间体，导致细胞氨基酸水平显著消耗，有用于线粒体转录等相关疾病的研究潜力。
T7700	Lersivirine 3-氰基-5-[[3,5-二乙基-1-(2-羟基乙基)-1H-吡唑-4-基]氧基]苯腈,Lersivirine(UK 453061),UK-453061	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Lersivirine (UK-453061) 是非核苷逆转录的抑制剂 (NNRTI)，有效抑制 NNRTI 耐药病毒。它对野生型人类免疫缺陷病毒和临床相关 NNRTI 耐药菌株显示出强大的抗逆转录病毒活性。
T40459	Transcriptional Intermediary Factor 2 (TIF2) (740-753) Transcriptional Intermediary Factor 2 (TIF2) (740-753)
	Transcriptional Intermediary Factor 2 (TIF2) (740-753) is a 14-amino acid peptide that serves as a coactivator of TIF-2 protein. It specifically covers residues 740-753 of the TIF-2 protein.
T2100	CX-5461	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	CX5461 是一种口服有效的rRNA 合成抑制剂，可抑制 Pol I 驱动的 rRNA 转录。
T15401	GNE-371	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	GNE-371 是一种选择性人类转录起始因子 TFIID 亚基 1 和转录起始因子 TFIID 亚基 1-like 第二溴结构域的探针。
T4302	iCRT3	Apoptosis; Wnt/beta-catenin	Apoptosis; Cytoskeletal Signaling; Stem Cells
	iCRT3 是一种Wnt 和 β-连环蛋白应答转录抑制剂。
T23151	Phortress NSC 710305	AhR	Immunology/Inflammation; Metabolism
	Phortress (NSC-710305) is a potent AhR ligand with strong binding affinity, which subsequently triggers the transcription of CYP1A1 and induces antitumor activity.
T14905	CCT251236	HSP	Cytoskeletal Signaling; Metabolism
	CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 induction (IC50: 19 nM).
T60619	CDK9-IN-15	CDK	Cell Cycle/Checkpoint
	CDK9-IN-15 是一种有效的小分子CDK9抑制剂，可通过降解、抑制 CDK9 来阻断正性转录延长因子 P-TEFb (positive transcription elongation factor b) 对 RNA Poly-II C末端区域的磷酸化，抑制转录，迅速降低细胞内 mRNA 水平，从而引起肿瘤细胞凋亡。
T11131	DW14800	Histone Methyltransferase	Chromatin/Epigenetic
	DW14800是PRMT5的抑制剂（IC50 = 17 nM），能增强HNF4α的转录，并降低H4R3me2s 的水平。
T17142	Toxoflavin 毒黄素,Xanthothricin,PKF-118-310,Toxoflavine	Wnt/beta-catenin; Antibacterial; Antibiotic	Cytoskeletal Signaling; Microbiology/Virology; Stem Cells
	Toxoflavin (Xanthothricin) 是一种 TCF4/β-catenin 复合物抑制剂，也是一种 KDM4A 抑制剂，有抗肿瘤和抗菌作用。
T1095	Sparfloxacin AT-4140,PD 131501,Zagam,司帕沙星,CI-978	DNA gyrase; Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Sparfloxacin (CI-978) 是一种氟喹诺酮类抗菌素。
T5416	T-5224	MMP	Proteases/Proteasome
	T-5224 是选择性的转录因子c-Fos/activator protein (AP)-1抑制剂，具有抗炎作用，能够特异性抑制 c-Fos/c-Jun 的 DNA 结合活性，但对其他转录因子的结合活性无影响。它抑制 IL-1β 诱导的 Mmp-3、Mmp-13、Adamts-5 转录上调。
T9632	CDK9-IN-30	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	CDK9-IN-30 是 Tat 肽衍生物之一，可抑制 HIV-1 长末端重复激活转录。
T4234	HJC0152 hydrochloride HJC0152	Apoptosis; STAT	Apoptosis; JAK/STAT signaling; Stem Cells
	HJC0152 hydrochloride (HJC0152) 是一种信号转导和转录激活因子 3的抑制剂。
T1563	Nifuroxazide Diarlidan,硝呋齐特,Nifuroxazid,Dicoferin,硝呋酚酰肼	Antibacterial; Antibiotic; STAT	JAK/STAT signaling; Microbiology/Virology; Stem Cells
	Nifuroxazide (Diarlidan) 是STAT3抑制剂，具有抗转移和抗癌活性。
T35544	ML115	STAT	JAK/STAT signaling; Stem Cells
	ML115 是一种有效且选择性的转录 3 (STAT3) 激活剂，abn EC50 为 2.0 nM，对相关的 STAT1 和 NFκB 抗靶点无活性。
T4252	ML327	c-Myc; Autophagy	Autophagy; Cell Cycle/Checkpoint
	ML327 是 MYC 的阻断剂，还可抑制 E-钙粘蛋白转录和逆转上皮间质转化。
T15370	GANT 58 4,44乔,4乔(2,3,4,5-Thiophentetrayl)tetrakis-pyridine,NSC 75503	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	GANT 58 (NSC-75503) 是GLI 拮抗剂，能够抑制 GLI1 诱导的转录，其IC50=5 μM。
T14969	CINPA1 CINPA-1,CINPA 1	Others	Others
	CINPA1 (CINPA 1) 是组成型雄甾烷受体 (CAR) 的特异性抑制剂，对 CAR 介导的转录的 IC50 为 70 nM。 CINPA1 可用于研究 CAR 功能。
T21813	OAC3 4-fluoro-N-(1H-indol-5-yl)benzamide	Others	Others
	OAC3 (4-fluoro-N-(1H-indol-5-yl)benzamide) 是八聚体结合转录因子 4 的激活剂。
T60051	VPC-18005	Others	Others
	VPC-18005 是一种荧光素酶抑制剂。 VPC-18005 抑制 ERG 诱导的转录并直接与 ERG-ETS 结构域相互作用，从而破坏 ERG 与 DNA 的结合。
T3460	HhAntag	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	HhAntag 是高效的、特异性的、具有口服活性的 Hh 通路的SMO 拮抗剂。
TP2506	Ser-Asn-Thr-Arg
	Ser-Asn-Thr-Arg 是一种四肽化合物，是通过转录激活因子样效应子截断形成的化合物。
T2014	CCG-1423 CCG1423	LRRK2; Rho; Ras	Autophagy; Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	CCG-1423 是一种选择性 RhoA 通路抑制剂，可抑制 SRF 介导的转录，能抑制细胞的转移前列腺癌PC-3细胞侵袭模型。
T4486	iCRT 14	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	iCRT 14 是 β-连环蛋白应答转录抑制剂，能够抑制 Wnt 信号通路(IC50:40.3 nM)。
T60160	STX-0119	STAT	JAK/STAT signaling; Stem Cells
	STX-0119 是一种选择性的、具有口服活性的 STAT3 二聚抑制剂。STX-0119 抑制 STAT3 转录，IC50 为 74 μM。
T6113	ICG-001	Apoptosis; Epigenetic Reader Domain; Wnt/beta-catenin	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Stem Cells
	ICG001 是β-catenin/TCF 介导的一种转录抑制剂，选择性地阻断 β-catenin/CBP 相互作用而不干扰 β-catenin/p300 相互作用。它可特异性结合 CREB 蛋白，IC50为3 μM。

化合物

NFAT Transcription Factor Regulator-1

Cat.No: T12218

Target: IL Receptor

signal transducer and activator of transcription 6 fragment

Cat.No: TP2291

Target: Others

653-47 hydrochloride

Cat.No: T8890

Target: Epigenetic Reader Domain

Cat.No: T22062

Target: Rho, Ras

Cat.No: T40661

Target: DNA/RNA Synthesis

Cat.No: T14495

Synonym: Baloxavir acid,S-033447

Target: Influenza Virus

Cat.No: T22667

Target: DNA/RNA Synthesis

Cat.No: T21767

Target: Others, Histone Methyltransferase

Cat.No: T27029

Synonym: cjoc 42,cjoc-42

Cat.No: T1767

Synonym: BMH21

Target: DNA/RNA Synthesis

Cat.No: T4356

Synonym: Compound 3A

Target: DNA/RNA Synthesis

Cat.No: T13166

Target: Others, DNA/RNA Synthesis

Cat.No: T22461

Target: CDK

Cat.No: T23820

Synonym: BRD-32048,BRD 32048

Target: DNA/RNA Synthesis

Cat.No: T12006

Synonym: ML246

Target: DNA/RNA Synthesis

Cat.No: T21807

Synonym: Triptycene-1,4-quinone

Target: Others

Ceramides Mixture

Cat.No: T10760

Synonym: 神经酰胺混合物,神经酰胺

Target: Telomerase

8-Hydroxyquinoline hemisulfate

Cat.No: T7887

Synonym: 8-羟基喹啉硫酸盐,Oxyquinoline sulfate

Target: Others, Antibacterial, Antibiotic

Cat.No: T8972

Target: Others, DNA/RNA Synthesis, CDK, HSV

Cat.No: T7764

Target: ROCK, Rho, Ras

Cat.No: T20759

Synonym: XRP-44-X,XRP 44X,XRP-44X,XRP 44 X

Target: Ras

Cat.No: T5045

Synonym: 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate,SR6452

Target: Autophagy

Cat.No: T8841

Synonym: Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)

Target: Others, DNA/RNA Synthesis, Mitochondrial Metabolism

Cat.No: T7700

Synonym: 3-氰基-5-[[3,5-二乙基-1-(2-羟基乙基)-1H-吡唑-4-基]氧基]苯腈,Lersivirine(UK 453061),UK-453061

Target: HIV Protease, Reverse Transcriptase

Transcriptional Intermediary Factor 2 (TIF2) (740-753)

Cat.No: T40459

Synonym: Transcriptional Intermediary Factor 2 (TIF2) (740-753)

Cat.No: T2100

Target: DNA/RNA Synthesis

Cat.No: T15401

Target: DNA/RNA Synthesis

Cat.No: T4302

Target: Apoptosis, Wnt/beta-catenin

Cat.No: T23151

Synonym: NSC 710305

Target: AhR

Cat.No: T14905

Target: HSP

Cat.No: T60619

Target: CDK

Cat.No: T11131

Target: Histone Methyltransferase

Cat.No: T17142

Synonym: 毒黄素,Xanthothricin,PKF-118-310,Toxoflavine

Target: Wnt/beta-catenin, Antibacterial, Antibiotic

Cat.No: T1095

Synonym: AT-4140,PD 131501,Zagam,司帕沙星,CI-978

Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic

Cat.No: T5416

Target: MMP

Cat.No: T9632

Target: HIV Protease

HJC0152 hydrochloride

Cat.No: T4234

Synonym: HJC0152

Target: Apoptosis, STAT

Cat.No: T1563

Synonym: Diarlidan,硝呋齐特,Nifuroxazid,Dicoferin,硝呋酚酰肼

Target: Antibacterial, Antibiotic, STAT

Cat.No: T35544

Target: STAT

Cat.No: T4252

Target: c-Myc, Autophagy

Cat.No: T15370

Synonym: 4,44乔,4乔(2,3,4,5-Thiophentetrayl)tetrakis-pyridine,NSC 75503

Target: Hedgehog/Smoothened

Cat.No: T14969

Synonym: CINPA-1,CINPA 1

Target: Others

Cat.No: T21813

Synonym: 4-fluoro-N-(1H-indol-5-yl)benzamide

Target: Others

Cat.No: T60051

Target: Others

Cat.No: T3460

Target: Hedgehog/Smoothened, Smo

Ser-Asn-Thr-Arg

Cat.No: TP2506

Cat.No: T2014

Synonym: CCG1423

Target: LRRK2, Rho, Ras

Cat.No: T4486

Target: Wnt/beta-catenin

Cat.No: T60160

Target: STAT

Cat.No: T6113

Target: Apoptosis, Epigenetic Reader Domain, Wnt/beta-catenin

Cat. No.	Product Name	Target	Signaling Pathways
T5689	20-DEOXYINGENOL	Others; Autophagy	Autophagy; Others
	20-Deoxyingenol 是从甘遂的根中分离出的一种二萜类天然产物。它可通过促进体外转录因子 EB 的核易位来促进自噬和溶酶体生物发生，可研究骨关节炎。
T13502	3-Oxo-5β-cholanoic acid 3-氧代-5β-胆烷酸,Dehydrolithocholic acid	ROR	Metabolism
	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) 是胆汁酸的一种代谢产物。3-Oxo-5β-cholanoic acid 直接与关键转录因子RORγt(Kd=1.13 μM) 结合抑制TH17细胞分化。
T6S1141	Ganoderic acid A 灵芝酸 A,灵芝酸A	Apoptosis; NF-κB; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Metabolism; NF-κB
	Ganoderic acid A 能够抑制 JAK-STAT3信号通路，也能抑制细胞增殖，存活率和 ROS。它对人骨肉瘤 HOS 和MG-63细胞具有增殖抑制、凋亡和侵袭抑制作用。
TN1836	Kudinoside D	LDL; AMPK; PPAR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
	Kudinoside D 是 Ilex kudingcha 中三萜皂苷的主要天然成分之一。它能够调节 3T3-L1 脂肪细胞中 AMPK 途径，并可抑制脂肪形成。
T4972	2'-Deoxycytidine-5'-diphosphate trisodium dCDP,2'-脱氧胞苷-5'-二磷酸三钠盐	Endogenous Metabolite	Metabolism
	2'-Deoxycytidine-5'-diphosphate trisodium (dCDP) 是内源性代谢产物的一种。
T3384	Wedelolactone 蟛蜞菊内酯,IKK Inhibitor II	Apoptosis; NF-κB; Lipoxygenase; Caspase	Apoptosis; Metabolism; NF-κB; Proteases/Proteasome
	Wedelolactone (IKK Inhibitor II) 是来自旱莲草的一种天然产物，通过阻断 IκBα 的磷酸化和降解来抑制细胞中 NF-κB 介导的基因转录，具有抗癌，抗炎和抗氧化活性。
T2896	Alantolactone 土木香内酯,helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,土木香脑,Inula camphor	Apoptosis; STAT; TGF-beta/Smad	Apoptosis; JAK/STAT signaling; Stem Cells
	Alantolactone (Inula camphor) 是一种STAT3的选择性抑制剂，可诱导癌症相关的凋亡，具有抗肿瘤活性。
T1168	Desonide Tridesilon,地索奈德,Locapred,Prednacinolone	Glucocorticoid Receptor	Endocrinology/Hormones
	Desonide (Prednacinolone) 是一种非氟化皮质类固醇抗炎剂，能够作用于糖皮质激素受体。
T2336	Vitamin K2 Menatetrenone,四烯甲萘醌	Endogenous Metabolite	Metabolism
	Vitamin K2 (Menatetrenone) 是内源性代谢产物的一种。
T5770	Alisol B	RANKL/RANK	NF-κB
	Alisol B 是一种具有用于骨科疾病研究潜力的化合物，通过分化破骨细胞发挥其功能。
TN1273	7,4'-Dihydroxyflavone 4',7-Dihydroxyflavone,7,4'-二羟基黄酮	NF-κB; COX; HDAC; CCR; NOD	Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB
	7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) 是从甘草中分离的类黄酮，是 eotaxin/CCL11抑制剂，抑制嗜酸性粒细胞趋化因子产生。它通过调节 NF-κB、STAT6 和 HDAC2，抑制 MUC5A 基因表达和粘液产生。
TN2121	3,5,7,3′,4′-Pentamethoxyflavone 栎精-3,5,7,3',4'-五甲醚,槲皮素3,5,7,3',4'-五甲基醚,Quercetin 3,5,7,3,4-pentamethyl ether	Others	Others
	3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) 是一种分离自小花山奈中的多甲氧基黄酮。在分化早期，它可以调控转录因子，促进 3T3-L1 前脂肪细胞形成脂肪。
TN1664	Ganoderic acid H	NF-κB; DNA/RNA Synthesis; CDK	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; NF-κB
	Ganoderic acid H 是一种羊毛脂烷型三萜，提取自灵芝中。它能够抑制转录因子AP-1 和 NF-kappaB 信号，并抑制乳腺癌细胞细胞的生长和入侵。
T5S0734	Desmethoxyyangonin Desmethoxy yangonin,去甲氧基醉椒素,Demethoxyyangonin,5,6-Dehydrokavain	Others; Monoamine Oxidase	Neuroscience; Others
	Desmethoxyyangonin (5,6-Dehydrokavain) 是一种MAO-B 可逆性抑制剂。
T10086	24-Hydroxycholesterol Cholest-5-ene-3beta,24-diol	Liver X Receptor; NMDAR	Metabolism; Neuroscience
	24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) 是一种氧甾醇化合物，是一种 n-甲基-d-天门冬氨酸受体 (NMDA) 和转录因子 LXR 的激活剂，可用于研究心血管生成和胰腺癌。
TN6393	fulvotomentoside A	Others	Others
	fulvotomentoside A 可降低肠道中 IL-6 和 IL-17A 的过表达，并显着增加调节性 T 细胞特异性转录因子 Foxp3 的表达。这可能是Ful 改善肠道炎症的机制之一。
TN1163	2'-Hydroxychalcone	Others	Others
	2'-Hydroxychalcone 是一种药物合成中间体，可用于合成黄酮类化合物。负载在纳米乳液中的2'-Hydroxychalcone 在Danio rerio 模型对副球孢子菌显示出杀真菌活性。2'-Hydroxychalcone 通过负载脂质的Hepg2细胞中的氧化应激诱导细胞毒性。2'-Hydroxychalcone 抑制通过逆转录聚合酶链反应确定的肿瘤坏死因子-α诱导ICAM-1，VCAM-1和E-选择素的稳态转录水平，因此可能会干扰其基因的转录。
T3363	Jervine 蒜黎芦碱,Iervin,11-Ketocyclopamine,Jerwiny	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	Jervine (Jerwiny) 是一种有效的刺猬 (Hh) 抑制剂(IC50:500-700 nM)。它是一种天然致畸性甾体生物碱，来自于 Veratrumalbum 的根茎，具有抗炎和抗氧化作用。
T5530	Mithramycin A Plicamycin	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Mithramycin A (Plicamycin) 是一种dna 结合的抗肿瘤抗生素，选择性特异性蛋白1 (Sp1)抑制剂，通过降低Sp1蛋白抑制多种肿瘤的生长。特异性蛋白1 (Sp1)是一种锌指转录因子，调节多种细胞功能，促进肿瘤进展。
T4010	Juglone 5-羟基对萘醌,5-Hydroxy-1,4-naphthoquinone,胡桃酮,Regianin	DNA/RNA Synthesis; Antibacterial	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Juglone (Regianin) 是一种从黑胡桃Juglans regia 中发现的黄色染料，有抗菌作用。
TN1237	3-O-Methylgallic acid 3,4-Dihydroxy-5-methoxybenzoic acid,3-O-甲基没食子酸	Apoptosis; NF-κB; OCT; DNA/RNA Synthesis; STAT	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; JAK/STAT signaling; Membrane transporter/Ion channel; NF-κB; Stem Cells
	3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) 是一种花青素代谢产物，具有强大的抗氧化能力。它还诱导细胞凋亡并具有抗癌作用，可抑制 Caco-2 细胞增殖，IC50值为 24.1 μM。
T20879	Tacrolimus monohydrate FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506	Phosphatase; Others; Antibacterial; Antibiotic; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Others
	Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物，它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶，从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。
T2S1837	Steviol 甜菊醇,NSC 226902,Hydroxydehydrostevic acid	Others	Others
	Steviol (NSC-226902) 是一种甜菊糖甙的主要代谢物。它能降低 AQP2 的表达，并促进 AQP2 的降解，从而减缓肾囊肿的生长。
T0034	Cortisone acetate 醋酸可的松,Cortisone 21-acetate,NSC 49420	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Cortisone acetate (NSC-49420) 是 Cortisol(一种糖皮质激素)的氧化代谢产物。它在高浓度下能够部分干预 Glucocorticoid 与Glucocorticoid-receptor 的结合。它具有免疫抑制和消炎的作用。
T2823	Crocin 西红花苷,藏红花,Gardenia Yellow,Alpha-Crocin,藏红花素	Others	Others
	Crocin (Gardenia Yellow) 是从Crocus sativus 柱头中分离出的主要成分，是一种营养保健品，具有抗炎，抗癌，抗抑郁和抗惊厥等强大的药理作用。
T1611	Isotretinoin 13-cis-Retinoic acid,异维A酸	Retinoid Receptor; Endogenous Metabolite; Autophagy	Autophagy; Metabolism
	Isotretinoin (13-cis-Retinoic acid) 是一种天然存在的维甲酸，具有潜在的抗肿瘤活性。它结合并激活核视黄酸受体 (RAR)，活化的 RARs 作为促进细胞分化和凋亡的转录因子。它是一种类维生素A 和维生素A 衍生物，用于治疗严重的痤疮和某些形式的皮肤、头颈癌。
T6429	Caffeic Acid Phenethyl Ester Phenylethyl Caffeate,咖啡酸苯乙酯,CAPE	Apoptosis; NF-κB	Apoptosis; NF-κB
	Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) 是咖啡酸的苯乙醇酯，是蜂巢蜂胶的生物活性成分。它抑制核转录因子 NF-kappa B 的激活，具有抗肿瘤、细胞保护和免疫调节活性。它抑制 PDGF 诱导的血管平滑肌细胞增殖。
T1719	Bufalin	ATPase	Membrane transporter/Ion channel
	Bufalin 是蟾酥中的一种成分，是Na+/K+-ATPase 抑制剂，具有抗肿瘤活性，可与其基 α1、α2 和 α3 结合，Kd 值分别为 42.5、45 和 40 nM。
T4S0878	Prunetin 樱黄素,Prunusetin	ERK; Dehydrogenase; NF-κB	MAPK; Metabolism; NF-κB
	Prunetin (Prunusetin) 是一种O-甲基化异黄酮，具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。
T6S1315	Oroxylin A 千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether	Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy	Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology
	Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮，具有较强的抗癌作用。
T2S0843	Negletein 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor; TNF; NOS; Interleukin	Apoptosis; Immunology/Inflammation
	Negletein (7-O-Methylbaicalein) 一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性，其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。
T13577	β-Zearalenol	Others	Others
	β-Zearalenol, a non-steroidal estrogenic mycotoxin synthesized by Fusarium species, potentially influences transcription and affects gene expression on the translational level.
TN5364	Boscialin
	Boscialin can inhibit signal transducer and activator of transcription 1 translocation at a concentration of 10 uM.
TN2249	(+)-Syringaresinol	Sirtuin; Antifection	Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.
T68731	Myxothiazol
	Myxothiazol is an inhibitor of mitochondrial respiratory chain complexes III. Myxothiazol induces transcription of the p53-responsive SESN2 gene that plays an important role in stress response and homeostatic regulation.
T19463	N4-Acetylcytidine triphosphate ac4CTP	Others	Others
	N4-Acetylcytidine triphosphate is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription .
T19462	N4-Acetylcytidine triphosphate sodium ac4CTP sodium	Others	Others
	N4-Acetylcytidine triphosphate sodium is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription.
T75666	Mogroside VI B
	Mogroside VI B，一种葫芦糖苷，从罗汉果粗提物中分离得到。Mogroside VI B 对 PGC-1α转录有激活作用。
TN1504	Citreorosein 羟基大黄素	cAMP; NF-κB; PI3K	GPCR/G Protein; NF-κB; PI3K/Akt/mTOR signaling
	Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation and subsequent inhibition of transcription factor NF-κB activation.
T13762	Luteolin 7-sulfate	Others	Others
	Luteolin 7-sulfate, derived from the marine plant Phyllospadix iwatensis Makino, suppresses TYR gene expression by intervening in a signaling pathway involving the cAMP-responsive element binding protein (CREB) and microphthalmia-associated transcription factor (MITF). This inhibition ultimately leads to a decrease in melanin synthesis.
TN2228	Soyasaponin Aa 大豆皂苷 AA,大豆皂苷Aa	PPAR	DNA Damage/DNA Repair; Metabolism
	Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the downregulation of the adipogenesis-related transcription factors PPARγ and C/EBPα± in 3T3-L1 adipo
T15467	Helenalin	Others	Others
	Helenalin is a selective inhibitor of transcription factor NF-κB by direct targeting of p65. It is an anti-inflammatory sesquiterpene lactone compound with alkylating activity. Through its ability to target the cysteine sulfhydryl groups in the p65 subunit of NF-κB, helenalin effectively inhibits its DNA binding.
T74203	Licoagrochalcone C
	Licoagrochalcone C 是一种类黄酮，对NF-κB 转录有抑制活性。Licoagrochalcone C 对 LPS 诱导的 NO 产生具有显着的抑制活性。
T71896	Brevicompanine B
	Brevicompanine B is a fungal metabolite that has plant growth and circadian rhythm regulatory activity. Brevicompanine B inhibits primary root growth in Arabidopsis seedlings and disrupts the transcription of various genes involved in the regulation of plant circadian rhythm. It is active against P. falciparum.
TN1862	Licoflavonol	Antifection	Microbiology/Virology
	Licoflavonol is a novel natural inhibitor of Salmonella T3SS, could be a promising candidate for novel type of anti-virulence drugs, it exhibits a strong inhibitory effect on the secretion of the SPI-1 effector proteins via regulating the transcription of
TN3410	Anatabine	Beta Amyloid; IL Receptor; TNF; NF-κB; BACE; COX; STAT	Apoptosis; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; NF-κB; Stem Cells
	Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheimer's disease effects, it inhibits BACE-1 transcription and reduces BACE-1 protein levels in hum
TN4490	Manassantin B	ERK; BCL; p38 MAPK; TNF; NF-κB; JNK; STAT; Antifection	Apoptosis; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells
	Manassantin B is a potent inhibitor of NF-ÎºB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎºB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in pa...
TN5369	Dehydroleucodine Dehydroleucodin
	Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating adipocyte differentiation by modulat
TN4092	Galanolactone	5-HT Receptor	GPCR/G Protein; Neuroscience
	Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, it has inhibit nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM. Galanolactone exerts anti-obesity effect through do
T72581	SARS-CoV MPro-IN-2
	SARS-CoVMPro-IN-2 是一种有效的SARS-CoV-2 Mpro 抑制剂，IC50sub>值为 72.07 nM。病毒的主要蛋白酶 Mpro 作为加工病毒多蛋白的主要酶，有助于 SARS-CoV-2 在宿主细胞中的复制和转录，并已被定性为药物发现的有吸引力的靶点。SARS-CoVMPro-IN-2 具有研究 COVID-19 的潜力。
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天然产物

20-DEOXYINGENOL

Cat.No: T5689

Target: Others, Autophagy

3-Oxo-5β-cholanoic acid

Cat.No: T13502

Synonym: 3-氧代-5β-胆烷酸,Dehydrolithocholic acid

Target: ROR

Ganoderic acid A

Cat.No: T6S1141

Synonym: 灵芝酸 A,灵芝酸A

Target: Apoptosis, NF-κB, Endogenous Metabolite, Autophagy

Cat.No: TN1836

Target: LDL, AMPK, PPAR

2'-Deoxycytidine-5'-diphosphate trisodium

Cat.No: T4972

Synonym: dCDP,2'-脱氧胞苷-5'-二磷酸三钠盐

Target: Endogenous Metabolite

Cat.No: T3384

Synonym: 蟛蜞菊内酯,IKK Inhibitor II

Target: Apoptosis, NF-κB, Lipoxygenase, Caspase

Cat.No: T2896

Synonym: 土木香内酯,helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,土木香脑,Inula camphor

Target: Apoptosis, STAT, TGF-beta/Smad

Cat.No: T1168

Synonym: Tridesilon,地索奈德,Locapred,Prednacinolone

Target: Glucocorticoid Receptor

Cat.No: T2336

Synonym: Menatetrenone,四烯甲萘醌

Target: Endogenous Metabolite

Cat.No: T5770

Target: RANKL/RANK

7,4'-Dihydroxyflavone

Cat.No: TN1273

Synonym: 4',7-Dihydroxyflavone,7,4'-二羟基黄酮

Target: NF-κB, COX, HDAC, CCR, NOD

3,5,7,3′,4′-Pentamethoxyflavone

Cat.No: TN2121

Synonym: 栎精-3,5,7,3',4'-五甲醚,槲皮素3,5,7,3',4'-五甲基醚,Quercetin 3,5,7,3,4-pentamethyl ether

Target: Others

Ganoderic acid H

Cat.No: TN1664

Target: NF-κB, DNA/RNA Synthesis, CDK

Desmethoxyyangonin

Cat.No: T5S0734

Synonym: Desmethoxy yangonin,去甲氧基醉椒素,Demethoxyyangonin,5,6-Dehydrokavain

Target: Others, Monoamine Oxidase

24-Hydroxycholesterol

Cat.No: T10086

Synonym: Cholest-5-ene-3beta,24-diol

Target: Liver X Receptor, NMDAR

fulvotomentoside A

Cat.No: TN6393

Target: Others

2'-Hydroxychalcone

Cat.No: TN1163

Target: Others

Cat.No: T3363

Synonym: 蒜黎芦碱,Iervin,11-Ketocyclopamine,Jerwiny

Target: Hedgehog/Smoothened, Smo

Cat.No: T5530

Synonym: Plicamycin

Target: DNA/RNA Synthesis

Cat.No: T4010

Synonym: 5-羟基对萘醌,5-Hydroxy-1,4-naphthoquinone,胡桃酮,Regianin

Target: DNA/RNA Synthesis, Antibacterial

3-O-Methylgallic acid

Cat.No: TN1237

Synonym: 3,4-Dihydroxy-5-methoxybenzoic acid,3-O-甲基没食子酸

Target: Apoptosis, NF-κB, OCT, DNA/RNA Synthesis, STAT

Tacrolimus monohydrate

Cat.No: T20879

Synonym: FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506

Target: Phosphatase, Others, Antibacterial, Antibiotic, Autophagy

Cat.No: T2S1837

Synonym: 甜菊醇,NSC 226902,Hydroxydehydrostevic acid

Target: Others

Cortisone acetate

Cat.No: T0034

Synonym: 醋酸可的松,Cortisone 21-acetate,NSC 49420

Target: Glucocorticoid Receptor, Endogenous Metabolite

Cat.No: T2823

Synonym: 西红花苷,藏红花,Gardenia Yellow,Alpha-Crocin,藏红花素

Target: Others

Cat.No: T1611

Synonym: 13-cis-Retinoic acid,异维A酸

Target: Retinoid Receptor, Endogenous Metabolite, Autophagy

Caffeic Acid Phenethyl Ester

Cat.No: T6429

Synonym: Phenylethyl Caffeate,咖啡酸苯乙酯,CAPE

Target: Apoptosis, NF-κB

Cat.No: T1719

Target: ATPase

Cat.No: T4S0878

Synonym: 樱黄素,Prunusetin

Target: ERK, Dehydrogenase, NF-κB

Cat.No: T6S1315

Synonym: 千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether

Target: Virus Protease, HIF/HIF Prolyl-Hydroxylase, Autophagy

Cat.No: T2S0843

Synonym: 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

Cat.No: T13577

Target: Others

Cat.No: TN5364

(+)-Syringaresinol

Cat.No: TN2249

Target: Sirtuin, Antifection

Cat.No: T68731

N4-Acetylcytidine triphosphate

Cat.No: T19463

Synonym: ac4CTP

Target: Others

N4-Acetylcytidine triphosphate sodium

Cat.No: T19462

Synonym: ac4CTP sodium

Target: Others

Cat.No: T75666

Cat.No: TN1504

Synonym: 羟基大黄素

Target: cAMP, NF-κB, PI3K

Luteolin 7-sulfate

Cat.No: T13762

Target: Others

Cat.No: TN2228

Synonym: 大豆皂苷 AA,大豆皂苷Aa

Target: PPAR

Cat.No: T15467

Target: Others

Licoagrochalcone C

Cat.No: T74203

Brevicompanine B

Cat.No: T71896

Cat.No: TN1862

Target: Antifection

Cat.No: TN3410

Target: Beta Amyloid, IL Receptor, TNF, NF-κB, BACE, COX, STAT

Cat.No: TN4490

Target: ERK, BCL, p38 MAPK, TNF, NF-κB, JNK, STAT, Antifection

Dehydroleucodine

Cat.No: TN5369

Synonym: Dehydroleucodin

Cat.No: TN4092

Target: 5-HT Receptor

SARS-CoV MPro-IN-2

Cat.No: T72581

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