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Anti-FOXO4 Antibody (5M471)

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产品编号 TMAC-01558
别名 trithorax homolog (Drosophila), translocated to 7, RGD1561201, Myeloid/lymphoid or mixed lineage leukemia, MLLT7, Mixed lineage leukemia, MGC120490, MGC117660, FOXO 4, Forkhead box O4, Fork head domain transcription factor AFX1, ALL1-fused gene from X chromosome, Afxh, AFX1, AFX

Anti-FOXO4 Antibody (5M471) 是一种 Rabbit 抗体，靶向 FOXO4。Anti-FOXO4 Antibody (5M471) 可用于 FCM,ICC/IF,IP,WB。

Anti-FOXO4 Antibody (5M471)

Anti-FOXO4 Antibody (5M471)

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产品编号 TMAC-01558 别名 trithorax homolog (Drosophila), translocated to 7, RGD1561201, Myeloid/lymphoid or mixed lineage leukemia, MLLT7, Mixed lineage leukemia, MGC120490, MGC117660, FOXO 4, Forkhead box O4, Fork head domain transcription factor AFX1, ALL1-fused gene from X chromosome, Afxh, AFX1, AFX

Anti-FOXO4 Antibody (5M471) 是一种 Rabbit 抗体，靶向 FOXO4。Anti-FOXO4 Antibody (5M471) 可用于 FCM,ICC/IF,IP,WB。

规格价格库存数量
50 μL
¥ 1,495
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100 μL
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-FOXO4 Antibody (5M471) is a Rabbit antibody targeting FOXO4. Anti-FOXO4 Antibody (5M471) can be used in FCM,ICC/IF,IP,WB.
别名trithorax homolog (Drosophila), translocated to 7, RGD1561201, Myeloid/lymphoid or mixed lineage leukemia, MLLT7, Mixed lineage leukemia, MGC120490, MGC117660, FOXO 4, Forkhead box O4, Fork head domain transcription factor AFX1, ALL1-fused gene from X chromosome, Afxh, AFX1, AFX
Ig Type
IgG
克隆号
5M471
交叉反应
Human,Mouse,Rat
验证活性
1. ICC staining FOXO4 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
2. ICC staining FOXO4 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
3. ICC staining FOXO4 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. Flow cytometric analysis of 293 cells with FOXO4 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
verifiedActivityverifiedActivityverifiedActivityverifiedActivity
应用FCMICC/IFIPWB
推荐剂量
WB: 1:1000; ICC/IF: 1:100-500; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景FKHR (for forkhead in rhabdomyosarcoma), FKHRL1, and AFX1 are members of a subfamily of the forkhead family of transcription factors. AFX1, also known as FoxO4, is expressed in a wide variety of tissues and, like other FKHR proteins, AFX1 contains a single forkhead domain and serine-proline-rich region, which mediate DNA binding. AFX1-mediated transcriptional activation is regulated by the serine/threonine kinase Akt1, which phosphorylates AFX1 and in turn, sequesters AFX1 in the cytosol, thereby blocking nuclear localization and DNA binding. Genetic mutations in FKHR genes, including the t(2;13) and t(1;3) translocations, are commonly found in alveolar rhabdomyosarcomas. Additionally, the t(x;11) translocation of the AFX1 gene, which involves the fusion of a serine-proline-rich sequence of AFX1 to the carboxy terminus of a truncated MLL, results in acute lymphocytic leukemia.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P98177
化学信息
分子量Theoretical: 54 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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