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Anti-FOXO4 Antibody (5M471)

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Anti-FOXO4 Antibody (5M471)
产品编号 TMAC-01558
别名 trithorax homolog (Drosophila), translocated to 7, RGD1561201, Myeloid/lymphoid or mixed lineage leukemia, MLLT7, Mixed lineage leukemia, MGC120490, MGC117660, FOXO 4, Forkhead box O4, Fork head domain transcription factor AFX1, ALL1-fused gene from X chromosome, Afxh, AFX1, AFX

Anti-FOXO4 Antibody (5M471) 是一种 Rabbit 抗体，靶向 FOXO4。Anti-FOXO4 Antibody (5M471) 可用于 WB,ICC/IF,IP,FCM。

Anti-FOXO4 Antibody (5M471)

Anti-FOXO4 Antibody (5M471)

Rating icon 还可以
Anti-FOXO4 Antibody (5M471)
产品编号 TMAC-01558 别名 trithorax homolog (Drosophila), translocated to 7, RGD1561201, Myeloid/lymphoid or mixed lineage leukemia, MLLT7, Mixed lineage leukemia, MGC120490, MGC117660, FOXO 4, Forkhead box O4, Fork head domain transcription factor AFX1, ALL1-fused gene from X chromosome, Afxh, AFX1, AFX

Anti-FOXO4 Antibody (5M471) 是一种 Rabbit 抗体，靶向 FOXO4。Anti-FOXO4 Antibody (5M471) 可用于 WB,ICC/IF,IP,FCM。

规格价格库存数量
50 μL
¥ 1,495
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100 μL
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-FOXO4 Antibody (5M471) is a Rabbit antibody targeting FOXO4. Anti-FOXO4 Antibody (5M471) can be used in WB,ICC/IF,IP,FCM.
别名trithorax homolog (Drosophila), translocated to 7, RGD1561201, Myeloid/lymphoid or mixed lineage leukemia, MLLT7, Mixed lineage leukemia, MGC120490, MGC117660, FOXO 4, Forkhead box O4, Fork head domain transcription factor AFX1, ALL1-fused gene from X chromosome, Afxh, AFX1, AFX
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. ICC staining FOXO4 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
2. ICC staining FOXO4 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
3. ICC staining FOXO4 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. Flow cytometric analysis of 293 cells with FOXO4 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
应用
WB
ICC/IF
IP
FCM
推荐剂量
WB: 1:1000; ICC/IF: 1:100-500; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景FKHR (for forkhead in rhabdomyosarcoma), FKHRL1, and AFX1 are members of a subfamily of the forkhead family of transcription factors. AFX1, also known as FoxO4, is expressed in a wide variety of tissues and, like other FKHR proteins, AFX1 contains a single forkhead domain and serine-proline-rich region, which mediate DNA binding. AFX1-mediated transcriptional activation is regulated by the serine/threonine kinase Akt1, which phosphorylates AFX1 and in turn, sequesters AFX1 in the cytosol, thereby blocking nuclear localization and DNA binding. Genetic mutations in FKHR genes, including the t(2;13) and t(1;3) translocations, are commonly found in alveolar rhabdomyosarcomas. Additionally, the t(x;11) translocation of the AFX1 gene, which involves the fusion of a serine-proline-rich sequence of AFX1 to the carboxy terminus of a truncated MLL, results in acute lymphocytic leukemia.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P98177
化学信息
分子量Theoretical: 54 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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