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Anti-MITF Antibody (9E208)

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Anti-MITF Antibody (9E208)
产品编号 TMAC-02589
别名 WS2A, WS2, MITF-A, Microphthalmia-associated transcription factor, MI, COMMAD, CMM8, Class E basic helix-loop-helix protein 32(bHLHe32), BHLHE32

Anti-MITF Antibody (9E208) 是一种 Rabbit 抗体，靶向 MITF。Anti-MITF Antibody (9E208) 可用于 WB,ICC,FCM。

Anti-MITF Antibody (9E208)

Anti-MITF Antibody (9E208)

Rating icon 还可以
Anti-MITF Antibody (9E208)
产品编号 TMAC-02589 别名 WS2A, WS2, MITF-A, Microphthalmia-associated transcription factor, MI, COMMAD, CMM8, Class E basic helix-loop-helix protein 32(bHLHe32), BHLHE32

Anti-MITF Antibody (9E208) 是一种 Rabbit 抗体，靶向 MITF。Anti-MITF Antibody (9E208) 可用于 WB,ICC,FCM。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-MITF Antibody (9E208) is a Rabbit antibody targeting MITF. Anti-MITF Antibody (9E208) can be used in WB,ICC,FCM.
别名WS2A, WS2, MITF-A, Microphthalmia-associated transcription factor, MI, COMMAD, CMM8, Class E basic helix-loop-helix protein 32(bHLHe32), BHLHE32
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of MiTF on PC-12 cells lysates using anti-MiTF antibody at 1/1,000 dilution.
2. ICC staining MiTF in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
3. ICC staining MiTF in A431 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. ICC staining MiTF in NIH/3T3 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
5. Flow cytometric analysis of SW480 cells with MiTF antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
应用
WB
ICC
FCM
推荐剂量
WB: 1:1000-2000; ICC: 1:100-500; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景MITF (microphthalmia-associated transcription factor) is a melanocytic nuclear protein that contains basic helix-loop-helix (HLH) and leucine zipper (LZ) domains. These protein motifs are frequently observed in other transcription factors and are particularly common to members of the Myc family. MITF can directly associate with DNA as a homodimer and is required for the development and differentiation of melanocytes. Its expression is upregulated by cAMP and cAMP-dependent pathways. MITF activates several different gene promoters by binding to their E-boxes. Tyrosinase, TRP1 and TRP2 are pigment synthesis genes activated by MITF. When MITF is phosphorylated on Ser73 (via the MAPK pathway), it associates with co-activators of the p300/CBP family and enhances transcription. MITF has several isoforms including MITF-M which is specifically expressed in melanocytes. In MITF-deficient mice there is a complete absence of melanocytes.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
O75030
化学信息
分子量Theoretical: 55 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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