规格

价格

库存

数量

5 μg

¥ 492

6-8日内发货

10 μg

¥ 820

6-8日内发货

20 μg

¥ 1,290

5日内发货

50 μg

¥ 2,480

5日内发货

100 μg

¥ 3,980

5日内发货

200 μg

¥ 6,420

5日内发货

500 μg

¥ 12,100

5日内发货

1 mg

¥ 17,300

5日内发货

生物活性

产品描述	Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.
生物活性	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
研究背景	Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.
种属	Human
表达系统	E. coli
标签	Tag Free
蛋白编号	AAH02338.1
氨基酸序列	Pro2-Leu318
蛋白构建	Pro2-Leu318
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
缓冲液	Supplied as a 0.2 μm filtered solution of 10 mM HEPES, 100 mM KCl, 50% Glycerol, pH 7.4.
别名	REF1, Redox Factor-1, HAP1, DNA-(Apurinic or Apyrimidinic Site) Lyase, APX, Apurinic-Apyrimidinic Endonuclease 1, APEX1, APEX Nuclease, APEX, APEN, APE-1REF-1, APE1, APE, AP Endonuclease 1
内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.

化学信息

分子量	40 KDa (reducing condition)

储存&溶解度

运输方式

In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.

存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

实际储存温度请以COA为准

APE Protein, Human, Recombinant

APE Protein, Human, Recombinant

产品介绍

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