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Anti-HIF-1 alpha Antibody (2F748)
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产品编号 TMAY-02183
别名 PASD8, MOP1, hypoxia inducible factor 1, α subunit (basic helix-loop-helix transcription factor), hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), HIF1-α, HIF-1α, HIF1-ALPHA, HIF-1alpha, HIF-1A, HIF-1 α, HIF1, bHLHe78
Anti-HIF-1 alpha Antibody (2F748) 是一种 Rabbit 抗体，靶向 HIF-1 alpha。Anti-HIF-1 alpha Antibody (2F748) 可用于 ICC/IF。
Anti-HIF-1 alpha Antibody (2F748)
331 Anti-HIF-1 alpha Antibody (2F748)
还可以产品编号 TMAY-02183 别名 PASD8, MOP1, hypoxia inducible factor 1, α subunit (basic helix-loop-helix transcription factor), hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), HIF1-α, HIF-1α, HIF1-ALPHA, HIF-1alpha, HIF-1A, HIF-1 α, HIF1, bHLHe78
Anti-HIF-1 alpha Antibody (2F748) 是一种 Rabbit 抗体，靶向 HIF-1 alpha。Anti-HIF-1 alpha Antibody (2F748) 可用于 ICC/IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 2,294 | 5日内发货 |
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生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-HIF-1 alpha Antibody (2F748) is a Rabbit antibody targeting HIF-1 alpha. Anti-HIF-1 alpha Antibody (2F748) can be used in ICC/IF. |
| 别名 | PASD8, MOP1, hypoxia inducible factor 1, α subunit (basic helix-loop-helix transcription factor), hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), HIF1-α, HIF-1α, HIF1-ALPHA, HIF-1alpha, HIF-1A, HIF-1 α, HIF1, bHLHe78 |
| Ig Type | Rabbit IgG |
| 克隆号 | 2F748 |
| 交叉反应 | Human |
| 验证活性 | Immunofluorescence staining of Human HIF1A in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human HIF1A monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to nucleus and cytoplasm. |
| 应用 | ICC/IF |
| 推荐剂量 | ICC-IF: 1:20-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human HIF-1 alpha / HIF1A (rh HIF-1 alpha / HIF1A; TMPY-01709; Q16665-1; Arg575-Asn826). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (HIF1). HIF1 is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). HIF-1 alpha is expressed in most tissues with the highest levels in the kidney and heart. It is overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors. HIF-1 alpha functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, it activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF1A plays an essential role in embryonic vascularization, tumor angiogenesis, and the pathophysiology of ischemic disease. HIF-1 alpha binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires the recruitment of transcriptional coactivators such as CREBPB and EP300. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human HIF-1 alpha / HIF1A Protein (TMPY-01709) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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