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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-YY1 Antibody (7S107)

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货号 TMAH-01261

别名 δ transcription factor, Yin and yang 1, Transcriptional repressor protein YY1, NF-E1, INO80S, INO80 complex subunit S, Delta transcription factor

Anti-YY1 Antibody (7S107) 是一种抗体，靶向 YY1。Anti-YY1 Antibody (7S107) 可用于 ELISA。

Anti-YY1 Antibody (7S107)

Anti-YY1 Antibody (7S107)

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Rating icon 还可以
货号 TMAH-01261 别名 δ transcription factor, Yin and yang 1, Transcriptional repressor protein YY1, NF-E1, INO80S, INO80 complex subunit S, Delta transcription factor

Anti-YY1 Antibody (7S107) 是一种抗体，靶向 YY1。Anti-YY1 Antibody (7S107) 可用于 ELISA。

规格价格库存数量
50 μL
¥ 1,305
5日内发货
100 μL
¥ 2,180
5日内发货
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产品介绍

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产品描述
Anti-YY1 Antibody (7S107) is an antibody targeting YY1. Anti-YY1 Antibody (7S107) can be used in ELISA.
别名δ transcription factor, Yin and yang 1, Transcriptional repressor protein YY1, NF-E1, INO80S, INO80 complex subunit S, Delta transcription factor
Ig Type
Rabbit IgG
克隆号
7S107
反应种属
Human
应用ELISA
抗体种类
Monoclonal
亚细胞定位Nucleus matrix. Note=Associated with the nuclear matrix.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Plays a role in regulating enhancer activation. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: Human YY1
抗原种属
Human
基因名称
YY1
基因ID
7528
Uniprot ID
P25490
研究领域
Epigenetics and Nuclear Signaling
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

Δ transcription factor
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