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Anti-HIF-1 alpha Antibody (7S100)
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还可以产品编号 TMAB-00858
别名 PASD8, MOP1, hypoxia inducible factor 1, α subunit (basic helix-loop-helix transcription factor), hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), HIF1-α, HIF-1α, HIF1-ALPHA, HIF-1alpha, HIF-1A, HIF-1 α, HIF1, bHLHe78
Anti-HIF-1 alpha Antibody (7S100) 是一种 Rabbit 抗体，靶向 HIF-1 alpha。Anti-HIF-1 alpha Antibody (7S100) 可用于 ICC/IF,WB。
Anti-HIF-1 alpha Antibody (7S100)
Anti-HIF-1 alpha Antibody (7S100)
一键复制产品信息 还可以产品编号 TMAB-00858 别名 PASD8, MOP1, hypoxia inducible factor 1, α subunit (basic helix-loop-helix transcription factor), hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), HIF1-α, HIF-1α, HIF1-ALPHA, HIF-1alpha, HIF-1A, HIF-1 α, HIF1, bHLHe78
Anti-HIF-1 alpha Antibody (7S100) 是一种 Rabbit 抗体，靶向 HIF-1 alpha。Anti-HIF-1 alpha Antibody (7S100) 可用于 ICC/IF,WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μL | ¥ 785 | 5日内发货 | |
| 50 μL | ¥ 1,395 | 5日内发货 | |
| 100 μL | ¥ 2,485 | 5日内发货 |
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产品介绍
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抗原信息
化学信息
| 产品描述 | Anti-HIF-1 alpha Antibody (7S100) is a Rabbit antibody targeting HIF-1 alpha. Anti-HIF-1 alpha Antibody (7S100) can be used in ICC/IF,WB. |
| 别名 | PASD8, MOP1, hypoxia inducible factor 1, α subunit (basic helix-loop-helix transcription factor), hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), HIF1-α, HIF-1α, HIF1-ALPHA, HIF-1alpha, HIF-1A, HIF-1 α, HIF1, bHLHe78 |
| Ig Type | IgG |
| 克隆号 | 7S100 |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | Western blot analysis of HeLa treated with CoCl2 cell lysate. Using HIF-1 Alpha (TMAB-00858) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at RT for 60 min.  |
| 应用 | ICC/IFWB |
| 推荐剂量 | WB: 1:500-1:2000; ICC/IF: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Cytoplasm. Nucleus. |
| 组织特异性 | Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumo |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Functions as a master transcriptional regulator of the adaptive response to hypoxia.Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. |
| 免疫原 | A synthesized peptide: human HIF 1 alpha |
| 抗原种属 | Human |
| 基因名称 | HIF1A |
| 基因ID | |
| 蛋白名称 | Hypoxia-inducible factor 1-alpha |
| Uniprot ID | |
| 研究领域 | HIF,Hydroxylases,HIF,Jumonji containing proteins,Methylation |
| 功能 | Functions as a master transcriptional regulator of theadaptive response to hypoxia. Under hypoxic conditions activatesthe transcription of over 40 genes, including, erythropoietin,glucose transporters, glycolytic enzymes, vascular endothelialgrowth factor, and other genes whose protein products increaseoxygen delivery or facilitate metabolic adaptation to hypoxia.Plays an essential role in embryonic vascularization, tumorangiogenesis and pathophysiology of ischemic disease. Binds to coreDNA sequence 5'-[AG]CGTG-3' within the hypoxia response element(HRE) of target gene promoters. Activation requires recruitment oftranscriptional coactivators such as CREBPB and EP300. Activity isenhanced by interaction with both, NCOA1 or NCOA2. Interaction withredox regulatory protein APEX seems to activate CTAD andpotentiates activation by NCOA1 and CREBBP. |
| 分子量 | Theoretical: 93 kDa. Actual: 110 kDa. |
| 颜色 | Transparent |
| 物理性状 | Liquid |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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