规格

价格

库存

数量

10 mg

待询

50 mg

待询

生物活性

产品描述

LPPM-8 is a ligand for Med25 and acts as an inhibitor of Med25 protein-protein interactions (PPI). It engages with Med25 via the H2 surface of its activator-interaction domain, thereby stabilizing full-length proteins in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcription activators (e.g., ATF6a). Med25 plays a role in the transcriptional regulation of RNA polymerase II-dependent genes and can form a transcription complex with ATF6α. LPPM-8 is valuable for studying the complex biology of Med25 and its Mediator complex.

体外活性

Med25 是 megadalton Mediator complex 的亚化学计量成分，通过蛋白相互作用在转录起始过程中桥接介体和转录激活因子，与两亲性 ETV/PEA3 家族 (细胞迁移、运动)、ATF6a (应激反应) 及 VP16 (病毒感染) 相关。LPPM-8 (10 和 20 μM) 抑制 VARIO68 细胞中的 Med25 依赖性基因 (MMP-9)。