CBL0137

Name: CBL0137
Brand: TargetMol
SKU: T4126
Price: 343 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.68%

货号 T4126Cas号 1197996-80-7

别名 Curaxin 137, CBLC137

CBL0137 (Curaxin 137) 是一种代谢稳定的 curaxin，可激活 p53 (EC50: 0.37 μM) 并抑制 NF-κB (EC50: 0.47 μM)。它在功能上使促进染色质转录复合物 (FACT) 失活，从而驱动对 p53 和 NF-κB 的影响并促进癌细胞死亡。口服 CBL0137 在小鼠体内具有广泛的抗癌活性，可根除耐药性癌症干细胞，并增强吉西他滨在胰腺癌临床前模型中的疗效。

CBL0137

一键复制产品信息

很棒

纯度: 99.68%

货号 T4126 别名 Curaxin 137, CBLC137Cas号 1197996-80-7

规格	价格	库存
1 mg	¥ 343	现货
5 mg	¥ 993	现货
10 mg	¥ 1,570	现货
25 mg	¥ 2,830	现货
50 mg	¥ 4,250	现货
100 mg	¥ 5,910	现货
1 mL x 10 mM (in DMSO)	¥ 919	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.68%

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

CBL0137 AI Summary

CBL0137 is a molecule that exhibits various bioactivities related to DNA binding and inhibition of DNA methylation mediated by the murine DNMT3A catalytic domain. It shows significant binding affinity to different 30-mer duplex DNA sequences with varying dissociation constants (Kd) and demonstrates the ability to inhibit the DNA methylation process catalyzed by DNMT3A, as indicated by its IC50 values. Additionally, it interacts with the murine DNMT3A catalytic domain, forming enzyme-DNA complexes. Overall, CBL0137 displays potent bioactivities in the context of DNA binding and inhibition of DNA methylation processes..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates the efficacy of gemcitabine in preClinicalal models of pancreatic cancer.
靶点活性	NF-κB:0.47 μM (EC50), p53:0.37 μM (EC50)
别名	Curaxin 137, CBLC137

化学信息

分子量	336.43
分子式	C₂₁H₂₄N₂O₂
CAS No.	1197996-80-7
Smiles	C(CNC(C)C)N1C=2C(C=3C1=CC=C(C(C)=O)C3)=CC(C(C)=O)=CC2
密度	no data available
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 25 mg/mL (74.31 mM), Sonication is recommended.

H2O: Insoluble

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.94 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9724 mL	14.8619 mL	29.7239 mL	148.6193 mL
5 mM	0.5945 mL	2.9724 mL	5.9448 mL	29.7239 mL
10 mM	0.2972 mL	1.4862 mL	2.9724 mL	14.8619 mL
20 mM	0.1486 mL	0.7431 mL	1.4862 mL	7.4310 mL
50 mM	0.0594 mL	0.2972 mL	0.5945 mL	2.9724 mL