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Anti-Phospho-YAP1 (Ser127) Antibody (8Q811)
还可以产品编号 TMAH-00977
别名 YAP1 (p-Ser127), YAP1 (p-S127), p-YAP1 (Ser127), p-YAP1 (S127), Phospho-YAP1 (S127)
Anti-Phospho-YAP1 (Ser127) Antibody (8Q811) 是一种抗体，靶向 Phospho-YAP1 (Ser127)。Anti-Phospho-YAP1 (Ser127) Antibody (8Q811) 可用于 ELISA, WB, IHC。
Anti-Phospho-YAP1 (Ser127) Antibody (8Q811)
Anti-Phospho-YAP1 (Ser127) Antibody (8Q811)
还可以产品编号 TMAH-00977 别名 YAP1 (p-Ser127), YAP1 (p-S127), p-YAP1 (Ser127), p-YAP1 (S127), Phospho-YAP1 (S127)
Anti-Phospho-YAP1 (Ser127) Antibody (8Q811) 是一种抗体，靶向 Phospho-YAP1 (Ser127)。Anti-Phospho-YAP1 (Ser127) Antibody (8Q811) 可用于 ELISA, WB, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,315 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-YAP1 (Ser127) Antibody (8Q811) is an antibody targeting Phospho-YAP1 (Ser127). Anti-Phospho-YAP1 (Ser127) Antibody (8Q811) can be used in ELISA, WB, IHC. |
| 别名 | YAP1 (p-Ser127), YAP1 (p-S127), p-YAP1 (Ser127), p-YAP1 (S127), Phospho-YAP1 (S127) |
| Ig Type | Rabbit IgG |
| 克隆号 | 8Q811 |
| 交叉反应 | Human |
| 验证活性 | 1. Western Blot -Positive WB detected in HepG2 whole cell lysate(treated with Calyculin A or not) -All lanes Phospho-YAP1 antibody at 0.83μg/ml -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 65 KDa -Observed band size: 65 KDa 2. IHC image of TMAH-00977 diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| 应用 | ELISA, WB, IHC |
| 推荐剂量 | WB:1:500-1:5000; IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cytoplasm. Nucleus. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization. Plays a key role in controlling cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Suppresses ciliogenesis via acting as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1. In conjunction with WWTR1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). Activates the C-terminal fragment (CTF) of ERBB4 (isoform 3). |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human Phospho-YAP1 (S127) |
| 抗原种属 | Human |
| 基因ID | 10413 |
| Uniprot ID | |
| 研究领域 | Signal Transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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