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Anti-ATF2 Antibody (8R854)
还可以产品编号 TMAH-00084
别名 TREB7, HB16, CRE-BP1, CREB-2, CREB2, activating transcription factor 2
Anti-ATF2 Antibody (8R854) 是一种抗体，靶向 ATF2。Anti-ATF2 Antibody (8R854) 可用于 ELISA, WB, IHC。
Anti-ATF2 Antibody (8R854)
Anti-ATF2 Antibody (8R854)
还可以产品编号 TMAH-00084 别名 TREB7, HB16, CRE-BP1, CREB-2, CREB2, activating transcription factor 2
Anti-ATF2 Antibody (8R854) 是一种抗体，靶向 ATF2。Anti-ATF2 Antibody (8R854) 可用于 ELISA, WB, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,305 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-ATF2 Antibody (8R854) is an antibody targeting ATF2. Anti-ATF2 Antibody (8R854) can be used in ELISA, WB, IHC. |
| 别名 | TREB7, HB16, CRE-BP1, CREB-2, CREB2, activating transcription factor 2 |
| Ig Type | Rabbit IgG |
| 克隆号 | 8R854 |
| 交叉反应 | Human |
| 验证活性 | 1. Western Blot -Positive WB detected in: K562 whole cell lysate, 293T whole cell lysate -All lanes: ATF2 antibody at 1.2μg/ml -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 55, 36, 24, 49, 53, 14, 25, 16 KDa -Observed band size: 70 KDa 2. IHC image of TMAH-00084 diluted at 1:115.5 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| 应用 | ELISA, WB, IHC |
| 推荐剂量 | WB:1:500-1:5000; IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Nucleus. Cytoplasm. Mitochondrion outer membrane. Note=Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co-localizes with the MRN complex in the IR-induced foci (IRIF). |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human ATF2 |
| 抗原种属 | Human |
| 基因ID | 1386 |
| Uniprot ID | |
| 研究领域 | Epigenetics and Nuclear Signaling |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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