ML 209

Name: ML 209
Brand: TargetMol
SKU: T37587
Price: 658 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.87%

货号 T37587Cas号 1334526-14-5

ML-209 是一种视黄酸相关的孤儿受体 RORγ 拮抗剂 (IC50= 1.1 μM)。ML-209 抑制 HEK293t 细胞中 RORγt 转录活性(IC50= 300 nM)。ML-209 不抑制细胞中 RORα。ML-209 对鼠 Th17 细胞分化具有选择性抑制，而不影响幼稚 CD4+ T 细胞分化为 Th1 和调节性 T 细胞。

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ML 209

一键复制产品信息

很棒

纯度: 99.87%

货号 T37587Cas号 1334526-14-5

规格	价格	库存
1 mg	¥ 658	现货
2 mg	¥ 953	现货
5 mg	¥ 1,560	现货
10 mg	¥ 1,980	现货
25 mg	¥ 3,290	现货
50 mg	¥ 4,820	现货
100 mg	¥ 6,620	现货
500 mg	¥ 13,200	现货

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COA HNMR LCMS 产品操作手册

产品介绍

ML 209 AI Summary

ML 209 exhibits significant bioactivity as an antagonist of various receptors and impacts cell viability and protein stability across different contexts. It displaces fluorescein-labeled 25-hydroxycholesterol from human RORgammat LBD with IC50 values of 51.0 nM and 605.0 nM in a fluorescence polarization assay, and inhibits the transactivation domain of RORgammat in HEK293t cells with an IC50 of 300.0 nM. The compound also shows antagonist activity against TRbeta, TRalpha, LXRalpha, and ERRalpha with IC50 values of 13000.0 nM, 4500.0 nM, 10000.0 nM, and 14000.0 nM respectively in HEK293t cells. Additionally, in Drosophila Schneider cells, it acts as a RORgammat antagonist with an IC50 of 1100.0 nM. In terms of cell viability, ML 209 has a varied impact. It shows a growth rate range from -0.14 to 0.81 in HEK293T cells, 0.9 to 0.96 in U2OS cells, and a broader range of -0.32 to 1.0 in human fibroblast cells, suggesting a complex relationship with cellular growth depending on the cell type. Furthermore, in a Thermal Shift Assay, ML 209 influences the melting temperatures of various protein regions, indicating it impacts protein stability differently. It stabilizes some regions, such as M26-R383 (ΔTM = 1.0°C), S229-K512 (ΔTM = 4.29°C), P449-E759 (ΔTM = 0.97°C), M626-G740 (ΔTM = 1.95°C), and N44-E168 (ΔTM = 0.54°C). Conversely, it destabilizes the G861-E979 region (ΔTM = -3.38°C), highlighting its diverse interaction profile with protein domains..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM). ML-209 inhibits RORγt-dependent differentiation of isolated na?ve cord blood human CD4+T cells into Th17 T helper cells.
靶点活性	RORγ:1.1 μM

化学信息

分子量	441.52
分子式	C₂₅H₃₁NO₆
CAS No.	1334526-14-5
Smiles	C(CC(=O)N1C[C@@H](C)C[C@@H](C)C1)(C2=C(OC)C=C(OC)C=C2O)C=3C=C4C(=CC3)OCO4

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 18.33 mg/mL (41.52 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 1.5 mg/mL (3.4 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2649 mL	11.3245 mL	22.6490 mL	113.2452 mL
5 mM	0.4530 mL	2.2649 mL	4.5298 mL	22.6490 mL
10 mM	0.2265 mL	1.1325 mL	2.2649 mL	11.3245 mL
20 mM	0.1132 mL	0.5662 mL	1.1325 mL	5.6623 mL