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顶部生物活性储存和溶解信息计算器

Anti-RB1 Antibody (6K434)

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Anti-RB1 Antibody (6K434)
产品编号 TMAC-03548
别名 Retinoblastoma-associated protein, Retinoblastoma, RB1, RB transcriptional corepressor 1, RB, pRb (Rb), pRb, PPP1R130, pp110, p110-RB1, p105-Rb, OSRC

Anti-RB1 Antibody (6K434) 是一种 Rabbit 抗体，靶向 RB1。Anti-RB1 Antibody (6K434) 可用于 WB,ICC/IF,IHC,IP。

Anti-RB1 Antibody (6K434)

Anti-RB1 Antibody (6K434)

Rating icon 还可以
Anti-RB1 Antibody (6K434)
产品编号 TMAC-03548 别名 Retinoblastoma-associated protein, Retinoblastoma, RB1, RB transcriptional corepressor 1, RB, pRb (Rb), pRb, PPP1R130, pp110, p110-RB1, p105-Rb, OSRC

Anti-RB1 Antibody (6K434) 是一种 Rabbit 抗体，靶向 RB1。Anti-RB1 Antibody (6K434) 可用于 WB,ICC/IF,IHC,IP。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-RB1 Antibody (6K434) is a Rabbit antibody targeting RB1. Anti-RB1 Antibody (6K434) can be used in WB,ICC/IF,IHC,IP.
别名Retinoblastoma-associated protein, Retinoblastoma, RB1, RB transcriptional corepressor 1, RB, pRb (Rb), pRb, PPP1R130, pp110, p110-RB1, p105-Rb, OSRC
Ig Type
IgG
交叉反应
Human,Mouse
验证活性
1. Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-Rb antibody. Counter stained with hematoxylin.
2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Rb antibody. Counter stained with hematoxylin.
应用
WB
ICC/IF
IHC
IP
推荐剂量
WB: 1:500-1000; IHC: 1:50-200; ICC/IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene. The retinoblastoma tumor suppressor gene product, known as Rb or pRb, regulates differentiation, apoptosis and cell cycle control by coordinating the cell cycle, at G1/S, with transcriptional machinery that includes the heterodimeric E2F family. During G1, cyclin D (D1, D2, D3)-dependent kinase-mediated phosphorylation of Rb at Ser 795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues, including Ser 249/Thr 252, Thr 373, Thr 356, Ser 780, Ser 807/Ser 811 and Thr 821/Thr 826. Hypophosphorylated Rb represses the transcription of genes controlling cell cycle through direct protein-protein interactions, by binding and inactivating the promoters of transcription factors, and through recruitment of histone deacetylase, which deacetylates promoter regions and enhances nucleosome formation, thereby masking transcription enhancing cis elements.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P06400
化学信息
分子量Theoretical: 105 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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