Anti-SOX-2 Polyclonal Antibody is a Rabbit antibody targeting SOX-2. Anti-SOX-2 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.

IgG

Mouse,Rat (predicted:Human,Chicken,Dog,Cow,Horse,Sheep)

1. Paraformaldehyde-fixed, paraffin embedded Rat Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with SOX2 Polyclonal Antibody, Unconjugated (TMAB-01758) at 1:200 overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining.
2. Paraformaldehyde-fixed, paraffin embedded Mouse Cerebrum; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with SOX2 Polyclonal Antibody, Unconjugated (TMAB-01758) at 1:200 overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining.

IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500

Polyclonal

KLH conjugated synthetic peptide: human SOX2

Human

SOX2

Transcription factor SOX-2

Surface molecules,Germ cell markers,Leucine Zipper,HMG Box,Neural Stem Cell marker,Neural Signal Transduction,Neurogenesis,Intracellular,Embryonic Germ Cells

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation.