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顶部生物活性储存和溶解信息计算器

Anti-STAT5B Antibody (1Y166)

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产品编号 TMAC-03889

别名 STAT5B, Signal Transducer and Activator of Transcription 5B

Anti-STAT5B Antibody (1Y166) 是一种 Rabbit 抗体，靶向 STAT5B。Anti-STAT5B Antibody (1Y166) 可用于 ICC/IF,IHC,IP,WB。

Anti-STAT5B Antibody (1Y166)

Anti-STAT5B Antibody (1Y166)

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Rating icon 还可以
产品编号 TMAC-03889 别名 STAT5B, Signal Transducer and Activator of Transcription 5B

Anti-STAT5B Antibody (1Y166) 是一种 Rabbit 抗体，靶向 STAT5B。Anti-STAT5B Antibody (1Y166) 可用于 ICC/IF,IHC,IP,WB。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-STAT5B Antibody (1Y166) is a Rabbit antibody targeting STAT5B. Anti-STAT5B Antibody (1Y166) can be used in ICC/IF,IHC,IP,WB.
别名STAT5B, Signal Transducer and Activator of Transcription 5B
Ig Type
IgG
克隆号
1Y166
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of STAT5b on different lysates using anti-STAT5b antibody at 1/1,000 dilution. Positive control: Lane 1: K562, Lane 2: Hela.
2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-STAT5b antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-STAT5b antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-STAT5b antibody. Counter stained with hematoxylin.
5. Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-STAT5b antibody. Counter stained with hematoxylin.
6. ICC staining STAT5b in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
7. ICC staining STAT5b in PC-3M cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
8. ICC staining STAT5b in RH-35 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
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应用ICC/IFIHCIPWB
推荐剂量
WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:100-500
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96% homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phos-phorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retin-oic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P51692
化学信息
分子量Theoretical: 90 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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