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Anti-STAT6 Antibody (5D324)
还可以产品编号 TMAY-02527
Anti-STAT6 Antibody (5D324) 是一种 Mouse 抗体，靶向 STAT6。Anti-STAT6 Antibody (5D324) 可用于 FCM。
Anti-STAT6 Antibody (5D324)
Anti-STAT6 Antibody (5D324)
还可以产品编号 TMAY-02527
Anti-STAT6 Antibody (5D324) 是一种 Mouse 抗体，靶向 STAT6。Anti-STAT6 Antibody (5D324) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-STAT6 Antibody (5D324) is a Mouse antibody targeting STAT6. Anti-STAT6 Antibody (5D324) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 5D324 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human Stat6 expression on HT-29 cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human Stat6, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human STAT6 (rh STAT6; TMPY-02603; P42226-1; Met1-Trp847). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p300 and the CREB-binding protein (CBP). NF-κB and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggests that the direct interaction between Stat6 and NF-κB may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-κB. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | FITC/PE |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human STAT6 protein (TMPY-02603) |
| 抗原种属 | Human |
| 研究领域 | Apoptosis Transcription Factors and Regulators |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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