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Anti-CDK7 Antibody (3Y405)
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产品编号 TMAC-00801
别名 TFIIH basal transcription factor complex kinase subunit, STK1, Serine/threonine-protein kinase 1, MO15, Cyclin-dependent kinase 7, Cell division protein kinase 7, CDKN7, CDK-activating kinase 1, CDK7, CAK1, CAK, 39 kDa protein kinase (p39 Mo15)
Anti-CDK7 Antibody (3Y405) 是一种 Rabbit 抗体，靶向 CDK7。Anti-CDK7 Antibody (3Y405) 可用于 WB,ICC/IF,IHC,FCM。
Anti-CDK7 Antibody (3Y405)
Anti-CDK7 Antibody (3Y405)
还可以产品编号 TMAC-00801 别名 TFIIH basal transcription factor complex kinase subunit, STK1, Serine/threonine-protein kinase 1, MO15, Cyclin-dependent kinase 7, Cell division protein kinase 7, CDKN7, CDK-activating kinase 1, CDK7, CAK1, CAK, 39 kDa protein kinase (p39 Mo15)
Anti-CDK7 Antibody (3Y405) 是一种 Rabbit 抗体，靶向 CDK7。Anti-CDK7 Antibody (3Y405) 可用于 WB,ICC/IF,IHC,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,495 | 5日内发货 | |
| 100 μL | ¥ 2,485 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-CDK7 Antibody (3Y405) is a Rabbit antibody targeting CDK7. Anti-CDK7 Antibody (3Y405) can be used in WB,ICC/IF,IHC,FCM. |
| 别名 | TFIIH basal transcription factor complex kinase subunit, STK1, Serine/threonine-protein kinase 1, MO15, Cyclin-dependent kinase 7, Cell division protein kinase 7, CDKN7, CDK-activating kinase 1, CDK7, CAK1, CAK, 39 kDa protein kinase (p39 Mo15) |
| Ig Type | IgG |
| 交叉反应 | Human |
| 验证活性 | 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Cdk7 antibody. Counter stained with hematoxylin. 2. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-Cdk7 antibody. Counter stained with hematoxylin. 3. ICC staining Cdk7 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. ICC staining Cdk7 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining Cdk7 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining Cdk7 in 293 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. Flow cytometric analysis of A431 cells with Cdk7 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:1000; IHC: 1:50-200; ICC/IF: 1:100-500; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Progression through the cell cycle requires activation of a series of enzymes designated cyclin dependent kinases (Cdks). The monomeric catalytic subunit Cdk2, a critical enzyme for initiation of cell cycle progression, is completely inactive. Partial activation is achieved by the binding of regulatory cyclins such as cyclin D1, while full activation requires additional phosphorylation at Thr 160. The enzyme responsible for the phosphorylation of Cdk2 on Thr 160 and also of Cdc2 p34 on Thr 161, designated Cdk-activating kinase (CAK), has been partially purified and shown to be comprised of a catalytic subunit and a regulatory subunit. The catalytic subunit, designated Cdk7, has been identified as the mammalian homolog of MO15, a protein kinase demonstrated in starfish and Xenopus. The regulatory subunit is a novel cyclin (cyclin H) and is required for activation of Cdk7. Like other Cdks, Cdk7 contains a conserved threonine residue required for full activity; mutation of this residue severely reduces CAK activity. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 39 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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