Name: SR-29065
Brand: TargetMol
SKU: T81107
Price: 9480 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 9,480

现货

5 mg

¥ 20,800

现货

10 mg

¥ 31,200

现货

25 mg

¥ 46,300

现货

50 mg

¥ 62,500

现货

生物活性

产品描述	SR-29065 is a selective REV-ERBα agonist that inhibits BMAL1 transcription within the circadian transcription–translation feedback loop, and it has been applied to evaluate whether targeting both negative regulatory limbs of circadian control yields synergistic anti-tumor effects in glioblastoma models, supporting its broader use in autoimmune disorder and circadian rhythm research.
靶点活性	NR1D1:0.11 µM
体外活性	方法：对 REV-ERBα 选择性配体进行构效关系优化，并在小鼠实验性自身免疫性脑脊髓炎（EAE）模型中进行体内评价。结果：SR-29065 降低了中枢神经系统中 T 细胞的频率和数量，并调控 REV-ERB 靶基因表达，表明其在体内实现了有效靶点结合[1]。
别名	SR-29065, SR29065, SR 29065

化学信息

分子量	518.52
分子式	C₂₄H₂₄F₆N₂O₂S
CAS No.	2756883-91-5
Smiles	CC(C)CN1C=C(C2=C1C=C(C=C2)C3=CC=CC=C3C(F)(F)F)C(C(F)(F)F)NS(=O)(=O)C4CC4

储存&溶解度

存储	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

SR-29065