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Anti-FOxM1 Antibody (6G924) 是一种 Mouse 抗体,靶向 FOxM1。Anti-FOxM1 Antibody (6G924) 可用于 WB,IP,IF。
Anti-FOxM1 Antibody (6G924) 是一种 Mouse 抗体,靶向 FOxM1。Anti-FOxM1 Antibody (6G924) 可用于 WB,IP,IF。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,990 | 5日内发货 | |
100 μL | ¥ 2,990 | 5日内发货 |
产品描述 | Anti-FOxM1 Antibody (6G924) is a Mouse antibody targeting FOxM1. Anti-FOxM1 Antibody (6G924) can be used in WB,IP,IF. |
别名 | Winged-helix factor from INS-1 cells, Transcription factor Trident, MPP 2, MPM-2 reactive phosphoprotein 2, M-phase phosphoprotein 2, HFH-11, HFH 11, Hepatocyte nuclear factor 3 forkhead homolog 11 (HFH-11, FOXM 1, Forkhead-related protein FKHL16, Forkhead box protein M1, FKHL16, FKHL 16 |
交叉反应 | Human,Mouse,Rat |
验证活性 | 1. A.Western blot analysis of FOXM1 expression in EGF treated HeLa (A) and U-2 OS (B) whole cell lysates. 2. Western blot analysis of FOXM1 expression in CCRF-CEM whole cell lysate. |
应用 | |
推荐剂量 | WB: 1:100-1000; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) |
抗体种类 | Monoclonal |
宿主来源 | Mouse |
构建方式 | Hybridoma Monoclonal Antibody |
纯化方式 | ProA affinity purified |
性状 | Liquid |
缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
研究背景 | The Fox family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. FOXM1, also known as FKHL16, MPP2 or Trident, is primarily expressed in proliferating cells. The gene encoding human FOXM1 maps to chromosome 12p13. The transcription element that restricts FOXM1 expression to proliferating cells is located 300 bp upstream of the start codon. FOXM1 is most abundant in thymus, testis, small intestine and colon. Alternative splicing generates FOXM1A and FOXM1B isoforms that contain PEST regions involved in rapid protein degradation. A decrease in FOXM1 expression is associated with age-related defects in cellular proliferation. Conversely, an increase in FOXM1B expression in the livers of older transgenic mice restore hepatocyte DNA replication rates to the higher rate present in young livers. FOXM1B activates the transcription of cyclin B1, cyclin D1 and Cdc25B. |
偶联 | Unconjugated |
免疫原 | Peptide |
Uniprot ID |
分子量 | Theoretical: 83 kDa. |
储存方式 | Store at 2°C-8°C for 12 months, do not freeze. |
运输方式 | Shipping with blue ice. |
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