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Anti-NFATC4 Polyclonal Antibody

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货号 TMAB-01225

别名 T cell transcription factor NFAT3, Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 4, nuclear factor of activated T-cells cytoplasmic 4, Nuclear factor of activated T-cells, Nuclear factor of activated T cells cytoplasmic calcineurin dependent 4, Nuclear factor of activated T cells cytoplasmic 4, NFATC4 cytoplasmic 4, NF-ATc4, NFATc4, NF-AT3, NFAT3, NFAC4, NF ATc4

Anti-NFATC4 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NFATC4。Anti-NFATC4 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

Anti-NFATC4 Polyclonal Antibody

Anti-NFATC4 Polyclonal Antibody

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货号 TMAB-01225 别名 T cell transcription factor NFAT3, Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 4, nuclear factor of activated T-cells cytoplasmic 4, Nuclear factor of activated T-cells, Nuclear factor of activated T cells cytoplasmic calcineurin dependent 4, Nuclear factor of activated T cells cytoplasmic 4, NFATC4 cytoplasmic 4, NF-ATc4, NFATc4, NF-AT3, NFAT3, NFAC4, NF ATc4

Anti-NFATC4 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NFATC4。Anti-NFATC4 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-NFATC4 Polyclonal Antibody is a Rabbit antibody targeting NFATC4. Anti-NFATC4 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.
别名T cell transcription factor NFAT3, Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 4, nuclear factor of activated T-cells cytoplasmic 4, Nuclear factor of activated T-cells, Nuclear factor of activated T cells cytoplasmic calcineurin dependent 4, Nuclear factor of activated T cells cytoplasmic 4, NFATC4 cytoplasmic 4, NF-ATc4, NFATc4, NF-AT3, NFAT3, NFAC4, NF ATc4
反应种属
Mouse,Rat (predicted:Human,Dog,Pig,Cow,Horse,Sheep)
验证活性
1. Paraformaldehyde-fixed, paraffin embedded (rat lung); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (NFATC4) Polyclonal Antibody, Unconjugated (TMAB-01225) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
2. Paraformaldehyde-fixed, paraffin embedded (mouse placenta); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (NFATC4) Polyclonal Antibody, Unconjugated (TMAB-01225) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
verifiedActivityverifiedActivity
应用IFIHC-FrIHC-P
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:50-200
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.
组织特异性Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景The product of this gene is a member of the nuclearfactors of activated T cells DNA-binding transcription complex.This complex consists of at least two components: a preexistingcytosolic component that translocates to the nucleus upon T cellreceptor (TCR) stimulation and an inducible nuclear component.Other members of this family of nuclear factors of activated Tcells also participate in the formation of this complex. Theproduct of this gene plays a role in the inducible expression ofcytokine genes in T cells, especially in the induction of the IL-2and IL-4. Alternatively spliced transcript variants encodingdifferent isoforms have been noted for this gene. [provided byRefSeq, Oct 2008].
抗原信息
免疫原
KLH conjugated synthetic peptide: human NF-ATc4
抗原种属
Human
基因名称
NFATC4
基因ID
4776
蛋白名称
Nuclear factor of activated T-cells, cytoplasmic 4
Uniprot ID
Q14934
研究领域
NFATs,Other factors,Non-CD,NFATS
功能
Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL-4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons.
化学信息
分子量Theoretical: 95 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

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