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189

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11246	Etoricoxib-d4 MK-0663 D4,依托考昔 D4,L-791456 D4,Etoricoxib D4	Others	Others
	Etoricoxib D4 is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.Etoricoxib D4 is a deuterium labeled Etoricoxib.
T11870	Losartan D4 氯沙坦 D4,DuP-753 D4	Others	Others
	Losartan D4, the deuterium-labeled version of Losartan, functions as an angiotensin II receptor antagonist. It inhibits the interaction between angiotensin II and AT1 receptors by competing for binding, achieving an IC50 value of 20 nM.
T11591	Hydroxyzine D4 羟嗪 D4	Others	Others
	Hydroxyzine D4 is a deuterium-labeled variation of Hydroxyzine, a chemical compound known for its anticholinergic, anxiolytic, and analgesic properties. It is classified as a heterocyclic histamine H1-receptor antagonist.
T12300	Olmesartan-d4 RNH-6270 D4,奥美沙坦 D4	Others	Others
	Olmesartan D4 is the deuterium labeled Olmesartan. Olmesartan is an antagonist of angiotensin II receptor (AT1R) used to treat high blood pressure.
T11655	Indomethacin-D4 Indometacin-D4,吲哚美辛-D4	CDK	Cell Cycle/Checkpoint
	Indomethacin-D4 is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells.
T12230	Nitazoxanide-d4 NTZ D4,NSC-697855 D4,硝唑尼特 D4,Nitazoxanide D4	Others	Others
	Nitazoxanide D4 is the deuterium labeled Nitazoxanide.
T11247	Etravirine D4 R-165335 D4,TMC-125 D4,依曲韦林 D4	Others	Others
	Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV. Etravirine D4 is the deuterium labeled Etravirine.
T11675	Irbesartan-d4 厄贝沙坦 D4,SR-47436 D4,BMS-186295 D4	Others	Others
	Irbesartan D4, a deuterium-labeled variant of Irbesartan, is a highly potent and specific antagonist of the angiotensin II type 1 (AT1) receptor.
T19602	Vitamin D4 维生素 D4	Others	Others
	Vitamin D4 is the active Vitamin D analog.
T38042	Resolvin D4 Resolvin D4,RvD4
	Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid . [1] It has been detected in human milk, in the dorsal pouch of mice before and after infection with S. aureus, and in untreated tissues from humans, mice, and sardines.[2][3] RvD4, at 10 ng/mouse, reduces neutrophil infiltration in zymosan A-induced peritonitis and, at 200 ng/mouse, diminishes neutrophil infiltration in response to S. aureus infection. [3] With isolated cells, RvD4 promotes phagocytosi...
T19547	Rebamipide-d4 OPC12759 D4,瑞巴派特 D4,Rebamipide D4,Proamipide D4	Others	Others
	Rebamipide D4 is deuterium labeled Rebamipide.
T11934	Macitentan-d4 Macitentan D4,ACT-064992 D4	Endothelin Receptor	GPCR/G Protein
	Macitentan-d4 (ACT-064992 D4) 是一种 Macitentan 氘代物，可被当作非多肽 ETA 和 ETB (内皮素受体)双拮抗剂。Macitentan-d4 比 Macitentan 毒性更低，半衰期更长，可用于研究由内皮素受体介导介导的疾病。
T11536	Haloperidol (D4') Haloperidol D4',氟哌啶醇 (D4')	Others	Others
	Haloperidol D4' is deuterium-labeled haloperidol. Haloperidol is a dopamine D2 receptor antagonist.
T11869	Losartan (D4 Carboxylic Acid) E-3174 D4,氯沙坦羧酸 D4,EXP-3174 D4	Others	Others
	Losartan D4 Carboxylic Acid is the deuterium labeled Losartan, which is an angiotensin II receptor antagonist.
T11072	Dofetilide D4 多非利特 D4,UK 68789 D4	Others	Others
	Dofetilide D4 (UK 68789 D4), a deuterium-labeled version of Dofetilide, is categorized as a Class III antiarrhythmic medication.
T10670	Candesartan-d4 坎地沙坦 D4,CV-11974 D4	Others	Others
	Candesartan D4 is the deuterium labeled Candesartan. Candesartan is an antagonist of angiotensin II receptor.
T38128	Leukotriene D4 Leukotriene D4 MaxSpec® Standard,LTD4
	Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. It is the first cysteinyl-leukotriene metabolite of LTC4 . Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity. LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of...
T13031	Sulfamethoxazole-d4 Ro 4-2130 D4,磺胺甲恶唑 D4	Others	Others
	Sulfamethoxazole D4 is a deuterium labeled Sulfamethoxazole (Ro 4-2130). Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic.
T11535	Haloperidol D4 氟哌啶醇D4	Others	Others
	Haloperidol D4 is deuterium-labeled haloperidol.
T69395	Nicotinamide-d4
	Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM). Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosyl...
T10306	Amoxicillin D4 Amoxycillin D4	Others	Others
	Amoxicillin D4 (Amoxycillin D4) is a deuterium-labeled Amoxicillin. Amoxicillin is an antibiotic with broad-spectrum antimicrobial activity.
T19198	Atovaquone-d4 阿托伐醌D4	Others	Others
	Atovaquone D4 is the deuterium-labeled Atovaquone. Atovaquone is a medication used to treat or prevent pneumocystis babesia, malaria, toxoplasmosis, and pneumonia.
T11639	Imatinib D4 CGP-57148B D4,STI571 D4	Others	Others
	Imatinib D4 is a deuterium-labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, PDGFR, v-Abl, and c-kit kinase activity.
T11679	Isavuconazole-d4 BAL-4815 D4,RO-0094815 D4,Isavuconazole D4	Others	Others
	Isavuconazole D4 is a deuterium labeled Isavuconazole. Isavuconazole is a triazole prodrug with antifungal activity against yeasts, molds, and dimorphic fungi.
T12618	Quetiapine-d4 fumarate Quetiapine D4 fumarate,富马酸奎硫平 D4	Others	Others
	Quetiapine D4 fumarate is the deuterium labeled Quetiapine fumarate. Quetiapine fumarate is a agonist of 5-HT receptors and a antagonist of dopamine receptor,with antidepressant and anxiolytic.
T10351	Aprocitentan D4 ACT-132577 D4	Others	Others
	Aprocitentan D4 (ACT-132577 D4) is a deuterium-labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is a dual ETA/ETB antagonist (IC50s: 3.4 nM and 987 nM; pA2s: 6.7 and 5.5).
T12488	Pitavastatin D4 NK-104 D4	Others	Others
	Pitavastatin D4 is deuterium labeled Pitavastatin. Pitavastatin is a potent inhibitor of HMG-CoA reductase.
T10992	Delamanid D4 OPC-67683 D4	Others	Others
	Delamanid D4 is deuterium-labeled Delamanid. Delamanid is a newer mycobacterial cell wall synthesis inhibitor that inhibits the synthesis of mucus acid.
T12618L	Quetiapine-d4 hemifumarate 半富马酸奎硫平 D4	Others	Others
	Quetiapine D4 hemifumarate is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a agonist of 5-HT receptors and a antagonist of dopamine receptor,with ntidepressant and anxiolytic.
T12522	Posaconazole-D4 SCH 56592-D4	Others	Others
	Posaconazole-D4, a deuterium-labeled variant of Posaconazole, is a broad-spectrum, second-generation triazole with antifungal activity.
T19203	Bendamustine D4 SDX-105 D4	Others	Others
	Bendamustine D4 is the deuterium-labeled Bendamustine. Bendamustine is a DNA cross-linking compound with alkylating and antimetabolite properties. Bendamustine causes DNA breaks.
T10669	Canagliflozin-d4 Canagliflozin D4	Others	Others
	Canagliflozin D4 is a deuterium-labeled Canagliflozin. Canagliflozin is an SGLT2 inhibitor.
T13023	Sulfadiazine-d4 Sulfadiazine D4	Others	Others
	Sulfadiazine D4 is a deuterium labeled Sulfadiazine. Sulfadiazine used for the treatment of toxoplasmosis.
T13030	Sulfamethazine-D4 Sulfadimidine-D4,Sulfadimerazine-D4	Others	Others
	Sulfamethazine-D4 (Sulfadimidine-D4) is a deuterium labeled Sulfamethazine (Sulfadimidine). Sulfamethazine is an antimicrobial that is widely used to treat and prevent various animal diseases.
T12476	Pimozide-d4 Pimozide D4,R6238 D4	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Pimozide D4 is a deuterium labeled Pimozide.
T13026	Sulfadimethoxypyrimidine D4	Others	Others
	Sulfadimethoxypyrimidine D4, a deuterium-labeled version of Sulfadimethoxypyrimidine, is a sulfonamide antibiotic characterized by its broad-spectrum antibacterial effectiveness.
T11295	Flibanserin-d4 BIMT-17BS D4,BIMT-17 D4,Flibanserin D4	Others	Others
	Flibanserin, a compound identified as BIMT-17, acts as a complete agonist at the serotonin 5-HT1A receptor, with a binding affinity (Ki) of 1 nM, while functioning as an antagonist at the 5-HT2A receptor with a 49 nM affinity. Flibanserin D4 represents a deuterium-labeled version of Flibanserin.
T12329	Ospemifene D4 FC-1271a D4	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor.
T10528	Bexarotene D4 LGD1069 D4	Others	Others
	Bexarotene D4 is a deuterium-labeled Bexarotene (LGD1069). Bexarotene is a selective RXR agonist used in the treatment of cutaneous T-cell lymphoma.
T13035	Sulfathiazole-d4	Others	Others
	Sulfathiazole D4 is a deuterium labeled Sulfathiazole. Sulfathiazole used as a short-acting sulfonamide antibiotic.
T11250	Ezetimibe-d4 SCH 58235 D4	Others	Others
	Ezetimibe D4, a deuterium-labeled variant of Ezetimibe, functions as an inhibitor of Niemann-Pick C1-like1 (NPC1L1) and is recognized for its potent activation of Nrf2.
T11816	Lansoprazole-d4 AG-1749 D4,Lansoprazole D4	Proton pump	Membrane transporter/Ion channel
	Lansoprazole D4 (AG-1749 D4) is a deuterium labeled Lansoprazole. Lansoprazole is an inhibitor of proton pump which prevents the stomach from producing acid.
T13024	Sulfadimethoxine-d4 Sulphadimethoxine D4	Others	Others
	Sulfadimethoxine D4 is a deuterium labeled Sulfadimethoxine (Sulphadimethoxine). Sulfadimethoxine is a sulfonamide antibiotic used to treat many infections.
T12336	Oxaprozin D4 Wy-21743 D4	Others	Others
	Oxaprozin D4 is the deuterium labeled Oxaprozin, is a non-steroidal anti-inflammatory drug (NSAID).
T12479	Pioglitazone-d4 U 72107 D4	Others	Others
	Pioglitazone D4 is a deuterium labeled Pioglitazone. Pioglitazone is a agonist of PPARγ .
T12976	Sorafenib-d4 Sorafenib (D4),Bay 43-9006 (D4)	Others	Others
	Sorafenib D4 is the deuterium labeled Sorafenib. Sorafenib is an inhibitor of multikinase (Raf-1, B-Raf, and VEGFR-3 IC50s of 6 nM, 20 nM, and 22 nM, respectively).
T23938	D4-Ribavirin D4Ribavirin,D4 Ribavirin
	D4-Ribavirin is isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregular.
T12736	Rivaroxaban-d4 BAY 59-7939 D4	Factor Xa	Metabolism
	Rivaroxaban D4 is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent,selective and direct inhibitor of Factor Xa (FXa)(IC50:0.7 nM; Ki:0.4 nM).
T71981	Gliclazide-d4
	Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin...
T13141	Thalidomide D4	Others	Others
	Thalidomide D4 is a deuterium labeled Thalidomide, has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties.

化合物

Cat.No: T11246

Synonym: MK-0663 D4,依托考昔 D4,L-791456 D4,Etoricoxib D4

Target: Others

Cat.No: T11870

Synonym: 氯沙坦 D4,DuP-753 D4

Target: Others

Cat.No: T11591

Synonym: 羟嗪 D4

Target: Others

Cat.No: T12300

Synonym: RNH-6270 D4,奥美沙坦 D4

Target: Others

Indomethacin-D4

Cat.No: T11655

Synonym: Indometacin-D4,吲哚美辛-D4

Target: CDK

Nitazoxanide-d4

Cat.No: T12230

Synonym: NTZ D4,NSC-697855 D4,硝唑尼特 D4,Nitazoxanide D4

Target: Others

Cat.No: T11247

Synonym: R-165335 D4,TMC-125 D4,依曲韦林 D4

Target: Others

Cat.No: T11675

Synonym: 厄贝沙坦 D4,SR-47436 D4,BMS-186295 D4

Target: Others

Cat.No: T19602

Synonym: 维生素 D4

Target: Others

Cat.No: T38042

Synonym: Resolvin D4,RvD4

Cat.No: T19547

Synonym: OPC12759 D4,瑞巴派特 D4,Rebamipide D4,Proamipide D4

Target: Others

Cat.No: T11934

Synonym: Macitentan D4,ACT-064992 D4

Target: Endothelin Receptor

Haloperidol (D4')

Cat.No: T11536

Synonym: Haloperidol D4',氟哌啶醇 (D4')

Target: Others

Losartan (D4 Carboxylic Acid)

Cat.No: T11869

Synonym: E-3174 D4,氯沙坦羧酸 D4,EXP-3174 D4

Target: Others

Cat.No: T11072

Synonym: 多非利特 D4,UK 68789 D4

Target: Others

Cat.No: T10670

Synonym: 坎地沙坦 D4,CV-11974 D4

Target: Others

Cat.No: T38128

Synonym: Leukotriene D4 MaxSpec® Standard,LTD4

Sulfamethoxazole-d4

Cat.No: T13031

Synonym: Ro 4-2130 D4,磺胺甲恶唑 D4

Target: Others

Cat.No: T11535

Synonym: 氟哌啶醇D4

Target: Others

Nicotinamide-d4

Cat.No: T69395

Cat.No: T10306

Synonym: Amoxycillin D4

Target: Others

Cat.No: T19198

Synonym: 阿托伐醌D4

Target: Others

Cat.No: T11639

Synonym: CGP-57148B D4,STI571 D4

Target: Others

Isavuconazole-d4

Cat.No: T11679

Synonym: BAL-4815 D4,RO-0094815 D4,Isavuconazole D4

Target: Others

Quetiapine-d4 fumarate

Cat.No: T12618

Synonym: Quetiapine D4 fumarate,富马酸奎硫平 D4

Target: Others

Aprocitentan D4

Cat.No: T10351

Synonym: ACT-132577 D4

Target: Others

Pitavastatin D4

Cat.No: T12488

Synonym: NK-104 D4

Target: Others

Cat.No: T10992

Synonym: OPC-67683 D4

Target: Others

Quetiapine-d4 hemifumarate

Cat.No: T12618L

Synonym: 半富马酸奎硫平 D4

Target: Others

Posaconazole-D4

Cat.No: T12522

Synonym: SCH 56592-D4

Target: Others

Bendamustine D4

Cat.No: T19203

Synonym: SDX-105 D4

Target: Others

Canagliflozin-d4

Cat.No: T10669

Synonym: Canagliflozin D4

Target: Others

Sulfadiazine-d4

Cat.No: T13023

Synonym: Sulfadiazine D4

Target: Others

Sulfamethazine-D4

Cat.No: T13030

Synonym: Sulfadimidine-D4,Sulfadimerazine-D4

Target: Others

Cat.No: T12476

Synonym: Pimozide D4,R6238 D4

Target: Dopamine Receptor

Sulfadimethoxypyrimidine D4

Cat.No: T13026

Target: Others

Cat.No: T11295

Synonym: BIMT-17BS D4,BIMT-17 D4,Flibanserin D4

Target: Others

Cat.No: T12329

Synonym: FC-1271a D4

Target: Estrogen/progestogen Receptor

Cat.No: T10528

Synonym: LGD1069 D4

Target: Others

Sulfathiazole-d4

Cat.No: T13035

Target: Others

Cat.No: T11250

Synonym: SCH 58235 D4

Target: Others

Lansoprazole-d4

Cat.No: T11816

Synonym: AG-1749 D4,Lansoprazole D4

Target: Proton pump

Sulfadimethoxine-d4

Cat.No: T13024

Synonym: Sulphadimethoxine D4

Target: Others

Cat.No: T12336

Synonym: Wy-21743 D4

Target: Others

Pioglitazone-d4

Cat.No: T12479

Synonym: U 72107 D4

Target: Others

Cat.No: T12976

Synonym: Sorafenib (D4),Bay 43-9006 (D4)

Target: Others

Cat.No: T23938

Synonym: D4Ribavirin,D4 Ribavirin

Cat.No: T12736

Synonym: BAY 59-7939 D4

Target: Factor Xa

Cat.No: T71981

Cat.No: T13141

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T15686	L-741626 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole	Dopamine Receptor	GPCR/G Protein; Neuroscience
	L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) 是D2多巴胺受体选择性拮抗剂，对人 D2、D3 和 D4 受体的Ki 分别为 2.4、100 和 220 nM。
TN5180	Triptinin B	Others	Others
	Triptinin A and triptinin B are leukotriene D4 antagonist constituents.
T3369	Nuciferine (-)-Nuciferine,VLT 049,荷叶碱,Sanjoinine E	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Nuciferine ((-)-Nuciferine) 是一种在埃及蓝睡莲和水芙蓉中发现的生物碱，是5-HT2A、5-HT2B 和5-HT2C 拮抗剂，IC50分别为 478 nM、1 μM 和 131 nM。它也是5-HT7的反向激动剂，IC50为 150 nM。

天然产物

Cat.No: T15686

Synonym: 3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole

Target: Dopamine Receptor

Cat.No: TN5180

Target: Others

Cat.No: T3369

Synonym: (-)-Nuciferine,VLT 049,荷叶碱,Sanjoinine E

Target: Dopamine Receptor, 5-HT Receptor

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