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CD44 Protein, Human, Recombinant (His)

CD44 Protein, Human, Recombinant (His)

产品编号 TMPY-02033
别名: CD44 molecule (Indian blood group), IN, MC56, HUTCH-I, MIC4, CDW44, ECMR-III, Pgp1, CSPG8, HCELL, LHR, MDU2, MDU3

CD44 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.4 kDa and the accession number is P16070-1.

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CD44 Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
100 μg ¥ 3,820 现货
200 μg ¥ 6,750 5日内发货
500 μg ¥ 14,280 5日内发货
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产品目录号及名称: CD44 Protein, Human, Recombinant (His) (TMPY-02033)
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生物活性 Testing in progress
产品描述 CD44 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.4 kDa and the accession number is P16070-1.
种属 Human
表达系统 HEK293 Cells
标签 C-His
蛋白编号 P16070-1
别名 CD44 molecule (Indian blood group), IN, MC56, HUTCH-I, MIC4, CDW44, ECMR-III, Pgp1, CSPG8, HCELL, LHR, MDU2, MDU3
蛋白构建 The N-terminal fragment (Met 1-Pro 220) of Human CD44 (P16070-1) extracellular domain was fused with a polyhistidine tag at the C-terminus.
蛋白纯度 ≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

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分子量 23.4 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 CD44 is a type I transmembrane protein and a member of the cartilage link protein family. It is involved in cell-cell and cell-matrix interactions and signal transduction. Several CD44 ligands have been identified. The most extensively characterized ligand for CD44 is hyaluronan, a component of the extracellular matrix. CD44 protein is expressed on the majority of immune cells. The binding of CD44 to hyaluronan is induced on T lymphocytes after activation by antigen and on monocytes after stimulation by inflammatory agents. Under inflammatory conditions, CD44 on endothelial cells presents hyaluronan to CD44 on activated T lymphocytes and mediates a rolling interaction under flow conditions. Perturbations of the hyaluronan-CD44 interaction at the plasma membrane by various antagonists result in attenuation of receptor tyrosine kinase and transporter activities and inhibition of tumor progression in vivo. CD44 is known to interact with the ezrin family (ERM family) members and form a complex that plays diverse roles within both normal and abnormal cells, particularly cancer cells. CD44 and ezrin and their respective complex have properties suggesting that they may be important in the process of tumour-endothelium interactions, cell migrations, cell adhesion, tumour progression and metastasis.

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Keywords

CD44 Protein, Human, Recombinant (His) MDU 2 CD44 molecule (Indian blood group) IN MC56 HUTCH-I MDU-3 CSPG 8 MIC4 MC 56 CDW44 ECMR-III Pgp1 MDU-2 CSPG8 CSPG-8 MIC 4 HCELL MIC-4 LHR MDU2 CDW 44 CDW-44 MC-56 MDU3 CD44 molecule MDU 3 Indian blood group recombinant recombinant-proteins proteins protein

 

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