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Anti-CTLA-4 Antibody (3R734)
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产品编号 TMAY-01711
别名 IDDM12, GSE, GRD4, cytotoxic T-lymphocyte-associated protein 4, CTLA-4, CELIAC3, CD152, CD, ALPS5
Anti-CTLA-4 Antibody (3R734) 是一种 Mouse 抗体，靶向 CTLA-4。Anti-CTLA-4 Antibody (3R734) 可用于 WB。
Anti-CTLA-4 Antibody (3R734)
Anti-CTLA-4 Antibody (3R734)
还可以产品编号 TMAY-01711 别名 IDDM12, GSE, GRD4, cytotoxic T-lymphocyte-associated protein 4, CTLA-4, CELIAC3, CD152, CD, ALPS5
Anti-CTLA-4 Antibody (3R734) 是一种 Mouse 抗体，靶向 CTLA-4。Anti-CTLA-4 Antibody (3R734) 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,689 | 5日内发货 |
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生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CTLA-4 Antibody (3R734) is a Mouse antibody targeting CTLA-4. Anti-CTLA-4 Antibody (3R734) can be used in WB. |
| 别名 | IDDM12, GSE, GRD4, cytotoxic T-lymphocyte-associated protein 4, CTLA-4, CELIAC3, CD152, CD, ALPS5 |
| Ig Type | Mouse IgG1 |
| 克隆号 | 3R734 |
| 交叉反应 | Human |
| 验证活性 | Anti-CTLA4 mouse monoclonal antibody at 1:500 dilution. -Lane A: Raji Whole Cell Lysate. -Lane B: MOLT-4 Whole Cell Lysate. -Lane C: K562 Whole Cell Lysate. -Lane D: Jurkat Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size:25 kDa. -Observed band size:30 kDa |
| 应用 | |
| 推荐剂量 | WB: 1:500-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CTLA-4 (rh CTLA-4; TMPY-04824; NP_005205.2; Met1-Asp161). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsCTLA4 / CD152 Immune Checkpoint ProteinsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human CTLA-4 Protein (TMPY-04824) |
| 抗原种属 | Human |
| 研究领域 | ITIM/ITAM Immunoreceptors and Related Molecules, Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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