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Anti-TOP2A Antibody (4D479)

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Anti-TOP2A Antibody (4D479)
产品编号 TMAC-04086
别名 TOP2, EC 5.99.1.3, DNA topoisomerase II, DNA topoisomerase 2-alpha, alpha isozyme

Anti-TOP2A Antibody (4D479) 是一种 Rabbit 抗体，靶向 TOP2A。Anti-TOP2A Antibody (4D479) 可用于 WB,IHC,IP。

Anti-TOP2A Antibody (4D479)

Anti-TOP2A Antibody (4D479)

Rating icon 还可以
Anti-TOP2A Antibody (4D479)
产品编号 TMAC-04086 别名 TOP2, EC 5.99.1.3, DNA topoisomerase II, DNA topoisomerase 2-alpha, alpha isozyme

Anti-TOP2A Antibody (4D479) 是一种 Rabbit 抗体，靶向 TOP2A。Anti-TOP2A Antibody (4D479) 可用于 WB,IHC,IP。

规格价格库存数量
50 μL
¥ 1,485
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-TOP2A Antibody (4D479) is a Rabbit antibody targeting TOP2A. Anti-TOP2A Antibody (4D479) can be used in WB,IHC,IP.
别名TOP2, EC 5.99.1.3, DNA topoisomerase II, DNA topoisomerase 2-alpha, alpha isozyme
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of Topoisomerase : alpha on mouse testis lysates using anti-Topoisomerase : alpha antibody at 1/1,000 dilution.
2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Topoisomerase : alpha antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Topoisomerase : alpha antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-Topoisomerase : alpha antibody. Counter stained with hematoxylin.
5. Immunohistochemical analysis of paraffin-embedded mouse colon tissue using anti-Topoisomerase : alpha antibody. Counter stained with hematoxylin.
6. Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-Topoisomerase : alpha antibody. Counter stained with hematoxylin.
应用
WB
IHC
IP
推荐剂量
WB: 1:1000-2000; IHC: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景DNA topoisomerase I and II (Topo I and Topo II) are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Eukaryotic topoisomerases are capable of relaxing both positive and negative supercoils, whereas prokaryotic topoisomerases relax only negative supercoils. DNA topoisomerases play a role in DNA replication, recombination, and transcription and have been identified as targets of numerous anticancer drugs. Topo I, a ubiquitously expressed, soluble enzyme, acts by introducing a transient break in one strand of DNA, while Topo II acts by making a transient double-strand break. Topo II is encoded by two different genes to generate two distinct isoforms that are designated Topo IIα and Topo IIβ. Topo IIβ and Topo IIα, are largely homologous at their N-terminal three quarters, however, the C-terminal segments are considerably divergent, suggesting that these regions may mediate different cellular functions and account for the observed differential tissue expression patterns of the two isoforms.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P11388
化学信息
分子量Theoretical: 174 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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