Ecopipam (SCH 39166) hydrobromide is a highly potent, specific, and orally active dopamine D1/D5 receptor antagonist, displaying K i values of 1.2 nM for D1 and 2.0 nM for D5 receptors. It demonstrates over 40-fold greater selectivity for D1/D5 over D2, D4, 5-HT, and α2a receptors, with K i values of 0.98, 5.52, 0.08, and 0.73 μM, respectively. This compound is relevant for research into schizophrenia and obesity.

D1 receptor:1.2 nM (Ki), 5-HT receptor:80 nM (Ki), D2 Receptor:980 nM (Ki), D4 Receptor:5520 nM (Ki), α2A-adrenoceptor:731 nM (Ki), D5 receptor:2.0 nM (Ki)