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Anti-Phospho-PDCD4 (Ser457) Polyclonal Antibody 2

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货号 TMAB-11122

Anti-Phospho-PDCD4 (Ser457) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-PDCD4 (Ser457)。Anti-Phospho-PDCD4 (Ser457) Polyclonal Antibody 2 可用于 WB,ICC/IF。

Anti-Phospho-PDCD4 (Ser457) Polyclonal Antibody 2

Anti-Phospho-PDCD4 (Ser457) Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-11122

Anti-Phospho-PDCD4 (Ser457) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-PDCD4 (Ser457)。Anti-Phospho-PDCD4 (Ser457) Polyclonal Antibody 2 可用于 WB,ICC/IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

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产品描述
Anti-Phospho-PDCD4 (Ser457) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-PDCD4 (Ser457). Anti-Phospho-PDCD4 (Ser457) Polyclonal Antibody 2 can be used in WB,ICC/IF.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat,Chicken,Pig,Horse,Rabbit,Zebrafish,Sheep)
应用WBICC/IF
推荐剂量
WB: 1:500-2000; ICC/IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasm. Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serum.
组织特异性Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human PDCD4 around the phosphorylation site of Ser457
抗原种属
Human
基因名称
PDCD4
基因ID
27250
蛋白名称
Programmed cell death protein 4
Uniprot ID
Q53EL6
功能
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.
化学信息
分子量Theoretical: 52 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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