CD44 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 22.07 kDa and the accession number is P16070-1.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 μg | ¥ 3,820 | 5日内发货 | ||
1 mg | ¥ 24,900 | 5日内发货 |
生物活性 | Testing in progress |
产品描述 | CD44 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 22.07 kDa and the accession number is P16070-1. |
种属 | Human |
表达系统 | HEK293 Cells |
标签 | Tag Free |
蛋白编号 | P16070-1 |
别名 | MDU3, LHR, MC56, CDW44, CSPG8, IN, MDU2, HCELL, Pgp1, CD44 molecule (Indian blood group), MIC4, ECMR-III, HUTCH-I |
蛋白构建 | Human CD44 (P16070-1) (Met1-Pro220) |
蛋白纯度 | > 90 % as determined by SDS-PAGE. > 95 % as determined by SEC-HPLC. |
分子量 | 22.07 kDa (predicted) |
内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. |
研究背景 | CD44 is a type I transmembrane protein and a member of the cartilage link protein family. It is involved in cell-cell and cell-matrix interactions and signal transduction. Several CD44 ligands have been identified. The most extensively characterized ligand for CD44 is hyaluronan, a component of the extracellular matrix. CD44 protein is expressed on the majority of immune cells. The binding of CD44 to hyaluronan is induced on T lymphocytes after activation by antigen and on monocytes after stimulation by inflammatory agents. Under inflammatory conditions, CD44 on endothelial cells presents hyaluronan to CD44 on activated T lymphocytes and mediates a rolling interaction under flow conditions. Perturbations of the hyaluronan-CD44 interaction at the plasma membrane by various antagonists result in attenuation of receptor tyrosine kinase and transporter activities and inhibition of tumor progression in vivo. CD44 is known to interact with the ezrin family (ERM family) members and form a complex that plays diverse roles within both normal and abnormal cells, particularly cancer cells. CD44 and ezrin and their respective complex have properties suggesting that they may be important in the process of tumour-endothelium interactions, cell migrations, cell adhesion, tumour progression and metastasis. |
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CD44 Protein, Human, Recombinant MDU-2 MDU3 LHR MC56 MIC 4 MDU 3 CDW44 CSPG8 IN MIC-4 MDU2 HCELL CSPG 8 MDU 2 MC-56 Pgp1 Indian blood group CD44 molecule CDW-44 CD44 molecule (Indian blood group) MC 56 CDW 44 CSPG-8 MDU-3 MIC4 ECMR-III HUTCH-I recombinant recombinant-proteins proteins protein