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CD45R0 Protein, Human, Recombinant (His)

CD45R0 Protein, Human, Recombinant (His)

产品编号 TMPJ-00410
别名: CD45 antigen, L-CA, protein tyrosine phosphatase, receptor type, C, CD45, PTPRC, B220, LY5, receptor-type tyrosine-protein phosphatase C, CD45R, LCA

CD45R0 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 80-120 KDa and the accession number is P08575-4.

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CD45R0 Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
10 μg ¥ 750 5日内发货
50 μg ¥ 2,260 5日内发货
500 μg ¥ 12,800 5日内发货
1 mg ¥ 19,200 5日内发货
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产品目录号及名称: CD45R0 Protein, Human, Recombinant (His) (TMPJ-00410)
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产品描述 CD45R0 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 80-120 KDa and the accession number is P08575-4.
种属 Human
表达系统 HEK293 Cells
标签 C-6xHis
蛋白编号 P08575-4
别名 CD45 antigen, L-CA, protein tyrosine phosphatase, receptor type, C, CD45, PTPRC, B220, LY5, receptor-type tyrosine-protein phosphatase C, CD45R, LCA
氨基酸序列 Gln26­Lys416
蛋白构建 Gln26­Lys416
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 80-120 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. It is a variably glycosylated 180-220 kDa transmembrane protein that is abundantly expressed on all nucleated cells of hematopoietic origin. CD45 has several isoforms, expressed according to cell type, developmental stage and antigenic exposure. CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds. CD45 is moved into or out of the immunological synapse (IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton. Galectin interaction can be fine-tuned by varying usage of the heavily O-glycosylated spliced regions and sialylation of N-linked carbohydrates. Within the IS, CD45 dephosphorylates and negatively regulates the src family kinase, LCK. In other leukocytes, CD45 influences differentiation and links immunoreceptor signaling with cytokine secretion and cell survival, partially overlapping in function with DEP-1/CD148. CD45 deletion causes in severe immunodeficiency, while point mutations may be associated with autoimmune disorders.

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Keywords

CD45R0 Protein, Human, Recombinant (His) CD45 antigen L-CA protein tyrosine phosphatase, receptor type, C CD45 LY-5 CD-45 PTPRC CD 45 B 220 B220 LY 5 LY5 receptor-type tyrosine-protein phosphatase C CD45R LCA B-220 recombinant recombinant-proteins proteins protein

 

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