Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BRD4 BD2. Additionally, PROTAC BRD4 Degrader-15 demonstrates potent degradation activity against the BRD4 protein in PC3 prostate cancer cells.
产品描述 | PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BRD4 BD2. Additionally, PROTAC BRD4 Degrader-15 demonstrates potent degradation activity against the BRD4 protein in PC3 prostate cancer cells. |
靶点活性 | BRD4 BD2:8.1 nM (IC50), BRD4 BD1:7.2 nM (IC50) |
体外活性 | PROTAC BRD4 Degrader-15 (compound 13) (4 h) inhibits suppresses MYC gene transcript in MV4-11 AML cells, with an IC 50 of 15 nM[1]. PROTAC BRD4 Degrader-15 (6 days) inhibits the proliferation of HL-60 and PC3-S1 cells, with an IC 50 of 4.2 nM and 91 nM[1]. |
别名 | PROTAC BRD4 Degrader-15 |
分子量 | 1149.3 |
分子式 | C57H62F2N10O10S2 |
CAS No. | 2417370-67-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PROTAC BRD4 Degrader-15 2417370-67-1 PROTAC BRD4 Degrader15 PROTAC BRD-4 Degrader-15 PROTAC BRD4 Degrader 15 Inhibitor inhibitor inhibit