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Anti-PVRL1/NECTIN1 Antibody-Biotin (5X846)
还可以产品编号 TMAY-03787B
Anti-PVRL1/NECTIN1 Antibody-Biotin (5X846) 是一种 Biotin-conjugated Rabbit 抗体，靶向 PVRL1/NECTIN1。Anti-PVRL1/NECTIN1 Antibody-Biotin (5X846) 可用于 ELISA。
Anti-PVRL1/NECTIN1 Antibody-Biotin (5X846)
Anti-PVRL1/NECTIN1 Antibody-Biotin (5X846)
还可以产品编号 TMAY-03787B
Anti-PVRL1/NECTIN1 Antibody-Biotin (5X846) 是一种 Biotin-conjugated Rabbit 抗体，靶向 PVRL1/NECTIN1。Anti-PVRL1/NECTIN1 Antibody-Biotin (5X846) 可用于 ELISA。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-PVRL1/NECTIN1 Antibody-Biotin (5X846) is a Biotin-conjugated Rabbit antibody targeting PVRL1/NECTIN1. Anti-PVRL1/NECTIN1 Antibody-Biotin (5X846) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 5X846 |
| 交叉反应 | Rat |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 0.1-1 μg/mL |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Rat CD111 / Nectin-1 / PVRL1 (TMPY-02937; XP_236210.3; Met1-Ala354), and then biotinylated. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin-1; CD111), also known as PVRL1 is a cell adhesion molecule belonging to the immunoglobulin superfamily that can bind to virion glycoprotein D (gD) to mediate entry of herpes simplex viruses (HSV) and pseudorabies virus (PRV). CD111/Nectin-1/PVRL1 colocalizes with E-cadherin at adherens junctions in epithelial cells. The disruption of cell junctions can result in the redistribution of nectin-1. To determine whether disruption of junctions by calcium depletion influenced the susceptibility of epithelial cells to viral entry, Madin-Darby canine kidney cells expressing endogenous nectin-1 or transfected human nectin-1 were tested for the ability to bind soluble forms of viral gD and to be infected by HSV and PRV, before and after calcium depletion. It has been revealed that binding of HSV and PRV gD was localized to adherens junctions in cells maintained in normal medium but was distributed, along with nectin-1, over the entire cell surface after calcium depletion. Both the binding of gD and the fraction of cells that could be infected by HSV-1 and PRV were enhanced by calcium depletion. Taken together, CD111/Nectin-1/PVRL1 confined to adherens junctions in epithelial cells is not very accessible to virus, whereas dissociation of cell junctions releases nectin-1 to serve more efficiently as an entry recptor. |
| 偶联 | Biotin |
| 其他可选修饰符 | Unconjugated |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Rat CD111 / Nectin-1 / PVRL1 protein (TMPY-02937) |
| 抗原种属 | Rat |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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