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CD47 Protein, Human, Recombinant (aa 19-139, His)

产品编号 TMPY-06367

别名: OA3, CD47 molecule, MER6, IAP

CD47 Protein, Human, Recombinant (aa 19-139, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.17kDa and the accession number is NP_942088.1.

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CD47 Protein, Human, Recombinant (aa 19-139, His)

规格	价格/CNY		货期	数量
100 μg	￥ 4,140		5日内发货
1 mg	￥ 27,000		5日内发货

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生物活性

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参考文献

生物活性	1. Immobilized Human SIRP alpha hFc at 2 μg/ml (100 μl/well) can bind Human CD47 His , the EC50 is 50-150 ng/mL. 2.Loaded Anti-Human CD47 antibody, human IgG4 on ProA Biosensor, can bind Recombinant Human CD47 Protein, His Tag with an affinity constant of 4.6nM as determined in BLI assay (Routinely tested).
产品描述	CD47 Protein, Human, Recombinant (aa 19-139, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.17kDa and the accession number is NP_942088.1.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	NP_942088.1
别名	OA3, CD47 molecule, MER6, IAP
蛋白构建	The Human CD47 (NP_942088.1) (Gln19-Pro139) was expressed with a polyhistidine tag at the C-terminus.
蛋白纯度	≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
分子量	15.17kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. CD47 may play a role in membrane transport and/or integrin dependent signal transduction. It may prevent premature elimination of red blood cells. It also may be involved in membrane permeability changes induced following virus infection. By acting as an adhesion receptor for THBS1 on platelets, CD47 plays a role in both cell adhesion and in the modulation of integrins. It also plays an important role in memory formation and synaptic plasticity in the hippocampus.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy

参考文献

1. Brown EJ, et al. (2001) Integrin-associated protein (CD47) and its ligands. Trends Cell Biol. 11(3): 130-5. 2. Oldenborg PA. (2004) Role of CD47 in erythroid cells and in autoimmunity. Leuk Lymphoma. 45(7): 1319-27. 3. Kaczorowski DJ, et al. (2007) Targeting CD47: NO limit on therapeutic potential. Circ Res. 100(5): 602-3.

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Keywords

CD47 Protein, Human, Recombinant (aa 19-139, His) MER-6 OA3 MER 6 CD47 molecule MER6 OA-3 OA 3 IAP recombinant recombinant-proteins proteins protein

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