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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-NEDD4-2 Polyclonal Antibody

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货号 TMAB-09335

Anti-NEDD4-2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NEDD4-2。Anti-NEDD4-2 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-NEDD4-2 Polyclonal Antibody

Anti-NEDD4-2 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-09335

Anti-NEDD4-2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 NEDD4-2。Anti-NEDD4-2 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-NEDD4-2 Polyclonal Antibody is a Rabbit antibody targeting NEDD4-2. Anti-NEDD4-2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. May be recruited to exosomes by NDFIP1.
组织特异性Ubiquitously expressed, with highest levels in prostate, pancreas and kidney.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
抗原信息
免疫原
KLH conjugated synthetic peptide: human NEDD4L/NEDD4-2
抗原种属
Human
基因名称
NEDD4L
基因ID
23327
蛋白名称
E3 ubiquitin-protein ligase NEDD4-like
Uniprot ID
Q96PU5
功能
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.
化学信息
分子量Theoretical: 112 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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