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IL-1RA Protein, Human, Recombinant (hFc)

产品编号 TMPY-00852

别名: interleukin 1 receptor antagonist, MVCD4, IRAP, IL1RA, IL1F3, IL-1RN, IL-1ra, ICIL-1RA, IL-1ra3, DIRA

IL-1RA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.8 kDa and the accession number is P18510-1.

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IL-1RA Protein, Human, Recombinant (hFc)

规格	价格/CNY		货期	数量
50 μg	￥ 2,440		5日内发货
1 mg	￥ 22,400		5日内发货

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参考文献

生物活性	Testing in progress
产品描述	IL-1RA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.8 kDa and the accession number is P18510-1.

种属	Human
表达系统	HEK293 Cells
标签	N-hFc
蛋白编号	P18510-1
别名	interleukin 1 receptor antagonist, MVCD4, IRAP, IL1RA, IL1F3, IL-1RN, IL-1ra, ICIL-1RA, IL-1ra3, DIRA
蛋白构建	The mature form of Human IL1RA (NP_776214.1) (Arg 26-Glu 177) was fused with the Fc region of Human IgG1 at the N-terminus.
蛋白纯度	> 98 % as determined by SDS-PAGE
分子量	43.8 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.2. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A), and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of this protein-encoding gene is reported to be associated with an increased risk of osteoporotic fractures and gastric cancer. IL-1RA/IL1RN may inhibit the activity of IL-1 by binding to its receptor and it has no IL-1 like activity. Genetic variation in IL-1RA/IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in IL-1RA/IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) which is also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis, and pustulosis from birth.

参考文献

1. Langdahl BL,et al. (2000) Osteoporotic fractures are associated with an 86-base pair repeat polymorphism in the interleukin-1--receptor antagonist gene but not with polymorphisms in the interleukin-1beta gene. J Bone Miner. 15 (3): 402-14. 2. El-Omar EM,et al. (2000) Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature. 404 (6776): 398-402. 3. Steinkasserer A,et al. (1992) The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci. Genomics. 13 (3): 654-7.

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Keywords

IL-1RA Protein, Human, Recombinant (hFc) interleukin 1 receptor antagonist MVCD4 IRAP IL1RA IL1F3 IL-1RN IL-1ra ICIL-1RA IL-1ra3 MVCD-4 MVCD 4 DIRA recombinant recombinant-proteins proteins protein

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