规格

价格

库存

数量

1 mg

¥ 3,730

现货

5 mg

¥ 8,210

现货

10 mg

¥ 12,300

现货

25 mg

¥ 20,900

现货

生物活性

产品描述	AD4 is an artemisinin-derived proteolysis targeting chimera that selectively degrades PCLAF protein with subnanomolar potency in RS4;11 leukemia cells,AD4 leads to activation of the p21/Rb signaling axis, robust anti-tumor activity, and significantly prolonged survival in RS4;11 xenograft NOD/SCID mouse models, demonstrating both in vitro and in vivo therapeutic efficacy.
靶点活性	PCLAF:0.6 nM
体外活性	在细胞实验中，AD4 对 PCLAF 的 IC50 为 0.6 nM。PCLAF 水平的耗竭导致 DNA 修复机制的中断并抑制肿瘤细胞增殖 [1]。

化学信息

分子量	1035.23
分子式	C₅₅H₇₈N₄O₁₅
CAS No.	2918262-09-4
Smiles	C[C@@H]1[C@]2([C@]34[C@@](O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])(O[C@@H]1OCCN(CCO[C@H]5O[C@]6([C@]78[C@]([C@H]5C)(CC[C@@H](C)[C@@]7(CC[C@](C)(O6)OO8)[H])[H])[H])C(CCCCCCCNC9=C%10C(C(=O)N(C%10=O)C%11C(=O)NC(=O)CC%11)=CC=C9)=O)[H])[H]

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 80 mg/mL (77.28 mM), Sonication is recommended.

溶液配制表

DMSO

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

AD4