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Anti-NBL1 Antibody (2R803)
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产品编号 TMAY-00392
别名 NO3, neuroblastoma 1, DAN family BMP antagonist, Dana, DAN, D4H1S1733E
Anti-NBL1 Antibody (2R803) 是一种 Mouse 抗体，靶向 NBL1。Anti-NBL1 Antibody (2R803) 可用于 ELISA(Det),IHC-P。
Anti-NBL1 Antibody (2R803)
331 Anti-NBL1 Antibody (2R803)
还可以产品编号 TMAY-00392 别名 NO3, neuroblastoma 1, DAN family BMP antagonist, Dana, DAN, D4H1S1733E
Anti-NBL1 Antibody (2R803) 是一种 Mouse 抗体，靶向 NBL1。Anti-NBL1 Antibody (2R803) 可用于 ELISA(Det),IHC-P。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μL | ¥ 595 | 5日内发货 | |
| 100 μL | ¥ 1,689 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-NBL1 Antibody (2R803) is a Mouse antibody targeting NBL1. Anti-NBL1 Antibody (2R803) can be used in ELISA(Det),IHC-P. |
| 别名 | NO3, neuroblastoma 1, DAN family BMP antagonist, Dana, DAN, D4H1S1733E |
| Ig Type | Mouse IgG1 |
| 克隆号 | 2R803 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human DAN in human lung with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein). 2. Immunochemical staining of human DAN in human liver with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein). 3. Immunochemical staining of human DAN in human kidney with mouse monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein). |
| 应用 | ELISA(Det),IHC-P |
| 推荐剂量 | IHC-P: 1:50-1:200; ELISA(Det): 1:1000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human NBL1 / DAND1 / DAN (rh NBL1 / DAND1 / DAN; TMPY-01039; NP_005371.1; Met1-Asp180). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The Dan (Differential screening-selected gene aberrative in neuroblastoma, also known as N03) gene was first identified as the putative rat tumor suppressor gene and encodes a protein structurally related to Cerberus and Gremlin in the vertebrates. It is a founding member of the DAN family of secreted proteins, acts as an inhibitor of cell cycle progression, and is closely involved in retinoic acid-induced neuroblastoma differentiation. There are at least five mammalian protein members in the evolutionarily conserved Dan family including DAN, Gremlin/DRM, Cer1 (Cerberus-related), Dante, and PRDC (protein related to DAN and Cerberus), and share the C-terminal cystine-knot motif. As a secreted glycoprotein, DAN is a member of a class of glycoproteins shown to be secreted inhibitors of the transforming growth factor-beta (TGF-beta) and bone morphogenic protein pathways. It binds to BMPs and preventing their interactions with signaling receptor complexes, and accordingly regulates the processes of embryonic development and tissue differentiation. DAN gene product may have an important role in the regulation of the entry of cells into the S phase. Besides, the DAN gene product possesses an ability to revert phenotypes of transformed rat fibroblasts and represents a candidate tumor suppressor gene for neuroblastoma. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | HRP |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Protein: Human NBL1 / DAND1 / DAN protein (TMPY-01039) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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