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CD47 Protein, Human, Recombinant
产品编号 TMPY-04683
CD47 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3.
CD47 Protein, Human, Recombinant
产品编号 TMPY-04683
CD47 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μg | ¥ 4,470 | 现货 | |
| 200 μg | ¥ 7,900 | 5日内发货 | |
| 500 μg | ¥ 16,710 | 5日内发货 |
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产品信息
| 生物活性 | Measured by its ability to bind human SIRPA-His in functional ELISA. Measured by its ability to bind mouse SIRPA-His in functional ELISA.  |
| 产品描述 | CD47 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3. |
| 种属 | Human |
| 表达系统 | HEK293 Cells |
| 标签 | Tag Free |
| 蛋白编号 | Q08722-3 |
| 别名 | OA3,MER6,IAP,CD47 molecule |
| 蛋白构建 | A DNA sequence encoding the human CD47 (NP_942088.1) (Met1-Pro139) was expressed with six amino acids (LEVLFQ) at the C-terminus. Predicted N terminal: Gln 19 |
| 蛋白纯度 | ≥ 90 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.   |
| 分子量 | 14.5 kDa (predicted); 35 kDa (reducing condition, due to glycosylation) |
| 内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
| 缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| 复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| 存储 | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| 运输方式 | In general, Lyophilized powders are shipping with blue ice. |
| 研究背景 | CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. CD47 may play a role in membrane transport and/or integrin dependent signal transduction. It may prevent premature elimination of red blood cells. It also may be involved in membrane permeability changes induced following virus infection. By acting as an adhesion receptor for THBS1 on platelets, CD47 plays a role in both cell adhesion and in the modulation of integrins. It also plays an important role in memory formation and synaptic plasticity in the hippocampus.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
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