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Anti-CTLA-4 Antibody-Biotin (8I311)
还可以产品编号 TMAY-01710B
Anti-CTLA-4 Antibody-Biotin (8I311) 是一种 Biotin-conjugated Mouse 抗体，靶向 CTLA-4。Anti-CTLA-4 Antibody-Biotin (8I311) 可用于 ELISA。
Anti-CTLA-4 Antibody-Biotin (8I311)
Anti-CTLA-4 Antibody-Biotin (8I311)
还可以产品编号 TMAY-01710B
Anti-CTLA-4 Antibody-Biotin (8I311) 是一种 Biotin-conjugated Mouse 抗体，靶向 CTLA-4。Anti-CTLA-4 Antibody-Biotin (8I311) 可用于 ELISA。
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产品介绍
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抗原信息
| 产品描述 | Anti-CTLA-4 Antibody-Biotin (8I311) is a Biotin-conjugated Mouse antibody targeting CTLA-4. Anti-CTLA-4 Antibody-Biotin (8I311) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG2b |
| 克隆号 | 8I311 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 0.1-1 μg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CTLA-4 / CD152 (rh CTLA-4 / CD152; TMPY-04348; NP_005205.2; Met1-Phe162). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and then biotinylated. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsCTLA4 / CD152 Immune Checkpoint ProteinsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| 偶联 | Biotin |
| 其他可选修饰符 | Unconjugated |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Human CTLA-4 / CD152 protein (TMPY-04348) |
| 抗原种属 | Human |
| 研究领域 | ITIM/ITAM Immunoreceptors and Related Molecules, Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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