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Anti-CD44 Antibody (4P477)
还可以产品编号 TMAY-02282
Anti-CD44 Antibody (4P477) 是一种 Mouse 抗体，靶向 CD44。Anti-CD44 Antibody (4P477) 可用于 ELISA,ELISA(Cap),IHC-P。
Anti-CD44 Antibody (4P477)
Anti-CD44 Antibody (4P477)
还可以产品编号 TMAY-02282
Anti-CD44 Antibody (4P477) 是一种 Mouse 抗体，靶向 CD44。Anti-CD44 Antibody (4P477) 可用于 ELISA,ELISA(Cap),IHC-P。
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抗原信息
| 产品描述 | Anti-CD44 Antibody (4P477) is a Mouse antibody targeting CD44. Anti-CD44 Antibody (4P477) can be used in ELISA,ELISA(Cap),IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4P477 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human CD44 in human skin with mouse monoclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections. The image showing membrane staining of squamous epithelium cell. 2. Immunochemical staining of human CD44 in human esophagus with mouse monoclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections. The image showing membrane staining of squamous epithelium cell. 3. Immunochemical staining of human CD44 in human bladder carcinoma with mouse monoclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections. The image showing membrane staining of epithelium cell. |
| 应用 | ELISA,ELISA(Cap),IHC-P |
| 推荐剂量 | ELISA: 1:5000-1:10000; IHC-P: 1:100-1:500; ELISA(Cap): 1:1000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD44 (rh CD44; TMPY-02033; P16070-1; Met 1-Pro 220). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS with 10% Trehalose, pH7.0 |
| 研究背景 | CD44 is a type I transmembrane protein and a member of the cartilage link protein family. It is involved in cell-cell and cell-matrix interactions and signal transduction. Several CD44 ligands have been identified. The most extensively characterized ligand for CD44 is hyaluronan, a component of the extracellular matrix. CD44 protein is expressed on the majority of immune cells. The binding of CD44 to hyaluronan is induced on T lymphocytes after activation by antigen and on monocytes after stimulation by inflammatory agents. Under inflammatory conditions, CD44 on endothelial cells presents hyaluronan to CD44 on activated T lymphocytes and mediates a rolling interaction under flow conditions. Perturbations of the hyaluronan-CD44 interaction at the plasma membrane by various antagonists result in attenuation of receptor tyrosine kinase and transporter activities and inhibition of tumor progression in vivo. CD44 is known to interact with the ezrin family (ERM family) members and form a complex that plays diverse roles within both normal and abnormal cells, particularly cancer cells. CD44 and ezrin and their respective complex have properties suggesting that they may be important in the process of tumour-endothelium interactions, cell migrations, cell adhesion, tumour progression and metastasis. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CD44 protein (TMPY-02033) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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