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Anti-MUC1/CD227 Antibody (6D465)

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货号 TMAB-09091

Anti-MUC1/CD227 Antibody (6D465) 是一种 Rabbit 抗体，靶向 MUC1/CD227。Anti-MUC1/CD227 Antibody (6D465) 可用于 IHC-P,IF,IHC-Fr,WB。

Anti-MUC1/CD227 Antibody (6D465)

Anti-MUC1/CD227 Antibody (6D465)

一键复制产品信息
Rating icon 还可以
货号 TMAB-09091

Anti-MUC1/CD227 Antibody (6D465) 是一种 Rabbit 抗体，靶向 MUC1/CD227。Anti-MUC1/CD227 Antibody (6D465) 可用于 IHC-P,IF,IHC-Fr,WB。

规格价格库存数量
25 μL
¥ 795
5日内发货
50 μL
¥ 1,385
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-MUC1/CD227 Antibody (6D465) is a Rabbit antibody targeting MUC1/CD227. Anti-MUC1/CD227 Antibody (6D465) can be used in IHC-P,IF,IHC-Fr,WB.
Ig Type
IgG
克隆号
6D465
反应种属
Human
应用IHC-PIFIHC-FrWB
推荐剂量
IHC-P: 1: 200-1000; IF: 1: 200-1000; IHC-Fr: 1: 200-1000; WB: 1: 500-2000
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Secreted; Cell membrane. Cytoplasm. Nucleus. On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus and Apical cell membrane. Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions.
组织特异性Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform 7 is expressed in tumor cells only.
构建方式Recombinant Antibody
纯化方式Affinity Purification
性状Liquid
缓冲液PBS with 100 μg/ml BSA, 0.15% ProClin300 and 50% glycerol.
研究背景Mucins represent a family of glycoproteins characterized by repeat domains and dense O-glycosylation . MUC1 (or mucin 1) is aberrantly overexpressed in most human carcinomas. Increased expression of MUC1 in carcinomas reduces cell-cell and cell-ECM interactions. MUC1 is cleaved proteolytically, and the large ectodomain can remain associated with the small 25 kDa carboxy-terminal domain that contains a transmembrane segment and a 72-residue cytoplasmic tail. MUC1 interacts with ErbB family receptors and potentiates ERK1/2 activation. MUC1 also interacts with β-catenin, which is regulated by GSK-3β, PKCγ, and Src through phosphorylation at Ser44, Thr41, and Tyr46 of the MUC1 cytoplasmic tail. Overexpression of MUC1 potentiates transformation and attenuates stress-induced apoptosis through the Akt or p53 pathways
抗原信息
免疫原
A synthesized peptide: Human MUC1
抗原种属
Human
基因名称
MUC1
基因ID
4582
蛋白名称
Mucin-1
Uniprot ID
P15941
功能
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.
The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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