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Anti-CD4 Antibody-FITC (2I64)
还可以产品编号 TMAY-00765F
Anti-CD4 Antibody-FITC (2I64) 是一种 FITC-conjugated Mouse 抗体，靶向 CD4。Anti-CD4 Antibody-FITC (2I64) 可用于 FCM。
Anti-CD4 Antibody-FITC (2I64)
Anti-CD4 Antibody-FITC (2I64)
还可以产品编号 TMAY-00765F
Anti-CD4 Antibody-FITC (2I64) 是一种 FITC-conjugated Mouse 抗体，靶向 CD4。Anti-CD4 Antibody-FITC (2I64) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CD4 Antibody-FITC (2I64) is a FITC-conjugated Mouse antibody targeting CD4. Anti-CD4 Antibody-FITC (2I64) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 2I64 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human CD4 expression on human peripheral blood lymphocytes. Cells were stained with FITC-conjugated anti-Human CD4 and PE conjugated anti-Human CD3 (BD Pharmingen™ Cat. No. 561809). The dot plots were derived from events with the forward and side light-scatter characteristics of viable lymphocytes. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD4 (rh CD4; TMPY-01400; NP_000607.1; Met1-Trp390) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | T-cell surface glycoprotein CD4, is a single-pass type I membrane protein. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. The CD4 surface determinant, previously associated as a phenotypic marker for helper/inducer subsets of T lymphocytes, has now been critically identified as the binding/entry protein for human immunodeficiency viruses (HIV). The human CD4 molecule is readily detectable on monocytes, T lymphocytes, and brain tissues. All human tissue sources of CD4 bind radiolabeled gp120 to the same relative degree; however, the murine homologous protein, L3T4, does not bind the HIV envelope protein. CD4 is a co-receptor that assists the T cell receptor (TCR) to activate its T cell following an interaction with an antigen-presenting cell. Using its portion that resides inside the T cell, CD4 amplifies the signal generated by the TCR. CD4 interacts directly with MHC class II molecules on the surface of the antigen-presenting cell via its extracellular domain. The CD4 molecule is currently the object of intense interest and investigation both because of its role in normal T-cell function, and because of its role in HIV infection. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors.Viral protein U (VpU) of HIV-1 plays an important role in downregulation of the main HIV-1 receptor CD4 from the surface of infected cells. Physical binding of VpU to newly synthesized CD4 in the endoplasmic reticulum is an early step in a pathway leading to proteasomal degradation of CD4. Amino acids in both helices found in the cytoplasmic region of VpU in membrane-mimicking detergent micelles experience chemical shift perturbations upon binding to CD4, whereas amino acids between the two helices and at the C-terminus of VpU show no or only small changes, respectively. Paramagnetic spin labels were attached at three sequence positions of a CD4 peptide comprising the transmembrane and cytosolic domains of the receptor. VpU binds to a membrane-proximal region in the cytoplasmic domain of CD4. |
| 偶联 | FITC |
| 其他可选修饰符 | Unconjugated/APC/PerCP/PE |
| 可提供抗体种类 | 5 |
| 免疫原 | Recombinant Human CD4 protein (TMPY-01400) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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