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Anti-PVRL1/NECTIN1 Antibody-APC (3U994)
还可以产品编号 TMAY-01929A
Anti-PVRL1/NECTIN1 Antibody-APC (3U994) 是一种 APC-conjugated Mouse 抗体，靶向 PVRL1/NECTIN1。Anti-PVRL1/NECTIN1 Antibody-APC (3U994) 可用于 FCM。
Anti-PVRL1/NECTIN1 Antibody-APC (3U994)
Anti-PVRL1/NECTIN1 Antibody-APC (3U994)
还可以产品编号 TMAY-01929A
Anti-PVRL1/NECTIN1 Antibody-APC (3U994) 是一种 APC-conjugated Mouse 抗体，靶向 PVRL1/NECTIN1。Anti-PVRL1/NECTIN1 Antibody-APC (3U994) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-PVRL1/NECTIN1 Antibody-APC (3U994) is a APC-conjugated Mouse antibody targeting PVRL1/NECTIN1. Anti-PVRL1/NECTIN1 Antibody-APC (3U994) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2b |
| 克隆号 | 3U994 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human PVRL1(NECTIN1) expression on TF-1 cells. Cells were stained with APC-conjugated anti-Human PVRL1(NECTIN1). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | 2 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD111 / Nectin-1 / PVRL1 (rh CD111 / Nectin-1 / PVRL1; TMPY-01572; NP_002846.3; Met 1-Thr 334) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| 研究背景 | Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin-1; CD111), also known as PVRL1 is a cell adhesion molecule belonging to the immunoglobulin superfamily that can bind to virion glycoprotein D (gD) to mediate entry of herpes simplex viruses (HSV) and pseudorabies virus (PRV). CD111/Nectin-1/PVRL1 colocalizes with E-cadherin at adherens junctions in epithelial cells. The disruption of cell junctions can result in the redistribution of nectin-1. To determine whether disruption of junctions by calcium depletion influenced the susceptibility of epithelial cells to viral entry, Madin-Darby canine kidney cells expressing endogenous nectin-1 or transfected human nectin-1 were tested for the ability to bind soluble forms of viral gD and to be infected by HSV and PRV, before and after calcium depletion. It has been revealed that binding of HSV and PRV gD was localized to adherens junctions in cells maintained in normal medium but was distributed, along with nectin-1, over the entire cell surface after calcium depletion. Both the binding of gD and the fraction of cells that could be infected by HSV-1 and PRV were enhanced by calcium depletion. Taken together, CD111/Nectin-1/PVRL1 confined to adherens junctions in epithelial cells is not very accessible to virus, whereas dissociation of cell junctions releases nectin-1 to serve more efficiently as an entry recptor. |
| 偶联 | APC |
| 其他可选修饰符 | Unconjugated/PE |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human CD111 / Nectin-1 / PVRL1 protein (TMPY-01572) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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