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别名 Trophoblast leukocyte common antigen, TLX, Membrane cofactor protein
Anti-CD46 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting CD46. Anti-CD46 Monoclonal Antibody-Biotin can be used in ELISA, FCM, IF. 可用于 ELISA,FCM,IF。
Anti-CD46 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting CD46. Anti-CD46 Monoclonal Antibody-Biotin can be used in ELISA, FCM, IF. 可用于 ELISA,FCM,IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 1,399 | 7日内发货 | |
| 50 μg | ¥ 1,678 | 7日内发货 | |
| 100 μg | ¥ 2,349 | 7日内发货 |
| 产品描述 | Anti-CD46 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting CD46. Anti-CD46 Monoclonal Antibody-Biotin can be used in ELISA,FCM,IF. |
| 别名 | Trophoblast leukocyte common antigen, TLX, Membrane cofactor protein |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of CD46 overexpressed 322F cells with TMAZ-0191B, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISAFCMIF |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CD46 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in PBS. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity|(Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells|(Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3|(Microbial infection) Acts as a receptor for cultured Measles virus|(Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6|(Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes (PubMed: 11260136, PubMed: 11971006, PubMed: 7708671, PubMed: 9379894) |
| 偶联 | Biotin |
| 其他可选修饰符 | Unconjugated |
| 可提供抗体种类 | 2 |
| 免疫原 | CD46 |
| 抗原种属 | Human |
| 基因ID | |
| Uniprot ID | |
| 研究领域 | Drug Target |
| 分子量 | 150 kDa |
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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