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Anti-PVRL1/NECTIN1 Antibody (4N573)
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产品编号 TMAY-01928
别名 SK-12, PVRR1, PVRR, PRR1, PRR, poliovirus receptor-related 1 (herpesvirus entry mediator C), OFC7, nectin-1, HVEC, HV1S, HIgR, ED4, CLPED1, CD111
Anti-PVRL1/NECTIN1 Antibody (4N573) 是一种 Mouse 抗体，靶向 PVRL1/NECTIN1。Anti-PVRL1/NECTIN1 Antibody (4N573) 可用于 ELISA(Cap)。
Anti-PVRL1/NECTIN1 Antibody (4N573)
331 Anti-PVRL1/NECTIN1 Antibody (4N573)
还可以产品编号 TMAY-01928 别名 SK-12, PVRR1, PVRR, PRR1, PRR, poliovirus receptor-related 1 (herpesvirus entry mediator C), OFC7, nectin-1, HVEC, HV1S, HIgR, ED4, CLPED1, CD111
Anti-PVRL1/NECTIN1 Antibody (4N573) 是一种 Mouse 抗体，靶向 PVRL1/NECTIN1。Anti-PVRL1/NECTIN1 Antibody (4N573) 可用于 ELISA(Cap)。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μL | ¥ 590 | 5日内发货 | |
| 100 μL | ¥ 1,694 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-PVRL1/NECTIN1 Antibody (4N573) is a Mouse antibody targeting PVRL1/NECTIN1. Anti-PVRL1/NECTIN1 Antibody (4N573) can be used in ELISA(Cap). |
| 别名 | SK-12, PVRR1, PVRR, PRR1, PRR, poliovirus receptor-related 1 (herpesvirus entry mediator C), OFC7, nectin-1, HVEC, HV1S, HIgR, ED4, CLPED1, CD111 |
| Ig Type | Mouse IgG1 |
| 克隆号 | 4N573 |
| 交叉反应 | Human |
| 应用 | ELISA(Cap) |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD111/Nectin-1/PVRL1 (rh CD111/Nectin-1/PVRL1; TMPY-01572; NP_002846.3; Met1-Thr334). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin-1; CD111), also known as PVRL1 is a cell adhesion molecule belonging to the immunoglobulin superfamily that can bind to virion glycoprotein D (gD) to mediate entry of herpes simplex viruses (HSV) and pseudorabies virus (PRV). CD111/Nectin-1/PVRL1 colocalizes with E-cadherin at adherens junctions in epithelial cells. The disruption of cell junctions can result in the redistribution of nectin-1. To determine whether disruption of junctions by calcium depletion influenced the susceptibility of epithelial cells to viral entry, Madin-Darby canine kidney cells expressing endogenous nectin-1 or transfected human nectin-1 were tested for the ability to bind soluble forms of viral gD and to be infected by HSV and PRV, before and after calcium depletion. It has been revealed that binding of HSV and PRV gD was localized to adherens junctions in cells maintained in normal medium but was distributed, along with nectin-1, over the entire cell surface after calcium depletion. Both the binding of gD and the fraction of cells that could be infected by HSV-1 and PRV were enhanced by calcium depletion. Taken together, CD111/Nectin-1/PVRL1 confined to adherens junctions in epithelial cells is not very accessible to virus, whereas dissociation of cell junctions releases nectin-1 to serve more efficiently as an entry recptor. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human CD111/Nectin-1/PVRL1 Protein (TMPY-01572) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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