653
304
11
325
Cat. No. | Product Name | ||
---|---|---|---|
L1400 | MAPK 抑制剂库 | 365 compounds | |
365 种与MAPK 信号通路相关的生物活性小分子化合物的特有集合,可用于高通量筛选和高内涵筛选; | |||
L8600 | 泛素化化合物库 | 210 compounds | |
210 种泛素化相关的小分子,用于高通量和高内涵筛选; | |||
L3700 | JAK-STAT 化合物库 | 252 compounds | |
252 个 JAK/STAT 靶点相关的小分子化合物的独特集合,用于高通量、高内涵筛选; | |||
L1120 | AMPK靶向分子库 | 80 compounds | |
80 个靶向AMPK 的分子集合,可用于高通量和高内涵筛选; | |||
L3510 | 甲基化化合物库 | 128 compounds | |
128 种甲基化相关的化合物,可以用于高通量和高内涵筛选; | |||
L6140 | 糖类及苷类化合物库 | 362 compounds | |
362 种糖类或苷类的化合物,可用于高通量筛选和高内涵筛选; | |||
L5510 | 肝脏毒性化合物库 | 1001 compounds | |
1001 个肝脏毒性化合物的特有集合,可用于高通量、高内涵筛选,是毒理学研究的良好工具; | |||
L5300 | 线粒体靶向库 | 812 compounds | |
812 种具有潜在或确定线粒体靶向活性的化合物,以促进针对线粒体的药物研究; | |||
L7600 | 趋化因子抑制剂库 | 59 compounds | |
59 种趋化因子或其受体抑制剂的独特集合,可用于高通量筛选和高内涵筛选; | |||
L6720 | 抗COVID-19中药单体库 | 1147 compounds | |
根据抗新冠肺炎疫情过程中应用于临床治疗的中药方剂,收集了1147 种相关中药来源的单体化合物,可用于高通量和高内涵筛选,是抗新冠病毒药物研发的良好工具; | |||
L9300 | 大环化合物库 | 210 compounds | |
210 种活性已知的大环化合物,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3595 |
Resmetirom
VIA-3196,MGL3196 |
Thyroid hormone receptor(THR) | Endocrinology/Hormones |
Resmetirom (VIA-3196) 是一种高度选择性的THR-β激动剂(EC50:0.21 μM)。 | |||
T14343 |
Atreleuton
ABT-761,VIA-2291 |
Others | Others |
Atreleuton (ABT-761) is a potent and selective inhibitor of leukotriene formation[1][2][3]. As a reversible and orally bioavailable 5-Lipoxygenase (5-LO) inhibitor, Atreleuton (ABT-761) exhibits selectivity. | |||
T21662L |
Cadherin Peptide, avian Acetate
Cadherin Peptide, avian Acetate (127650-08-2 Free base) |
Others | Others |
Cadherin Peptide, avian Acetate 是一种肽,序列为 Leu-Arg-Ala-His-Ala-Val-Asp-Val-Asn-Gly-NH2。钙粘蛋白是一类 1 型跨膜蛋白。 | |||
T22168 |
Vialinin A
Terrestrin A |
DUB | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
Vialinin A (Terrestrin A) (Terrestrin A) 是一种具有抗氧化性质的对三苯化合物。Vialinin A (Terrestrin A) 是 TNF-α,USP4, USP5 和 SENP1 特异性蛋白酶 1 的有效抑制剂。Vialinin A (Terrestrin A) 可用于自身免疫疾病和癌症研究。 | |||
T124019 |
Isosalviamine A
|
||
Isosalviamine A 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124019。 | |||
T75594 | Harpactira Baviana Venom | ||
Harpactira Baviana Venom (Baboon Tarantula Venom) 是一种蜘蛛毒液,能够从皇帝巴布蜘蛛蜘蛛中获得。Harpactira Baviana Venom 可以调节 NaV1.8和诱导痛觉过敏。 | |||
T80446 |
ω-Conotoxin FVIA
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
ω-Conotoxin FVIA为N型钙离子通道(Cav2.2)的抑制剂,具有减轻尾神经损伤大鼠模型所诱导的机械性和热性异常疼痛的作用。该化合物在开发高效且低副作用止痛药物的研究中具有潜在应用价值。 | |||
T80458 |
ω-Conotoxin CVIA
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
ω-Conotoxin CVIA 为含27个氨基酸的神经肽毒素,作用为阻断电压敏感的钙通道(voltage sensitive calcium channels)。 | |||
T34500 |
Salviarin
|
||
Salviarin is a clerodane diterpene isolated from Salvia splendens. | |||
T124509 |
Vesuvianic acid
|
||
Vesuvianic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124509。 | |||
TP2062 |
ω-Conotoxin GVIA
|
||
Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo. | |||
T19089 |
(Z)-Viaminate
Ethyl 4-((2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenamido)benzoate |
Others | Others |
(Z)-Viaminate is a derivative of Retinoic acid. | |||
T75727 |
ω-Conotoxin GVIA TFA
|
||
ω-Conotoxin GVIA TFA 是一种 N 型钙通道 (Ca2+channel) 抑制剂。 | |||
T124077 |
Salvianan
|
||
Salvianan 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124077。 | |||
T80520 |
ω-conotoxin MoVIA
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
ω-conotoxin MoVIA为选择性Cav2.2抑制剂,SH-SY5Y细胞荧光测定法中hCav2.2的IC50值为0.33 μM。 | |||
T124018 |
Isosalviamine B
|
||
Isosalviamine B 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124018。 | |||
T5367 |
3-TERT-BUTYL-4-HYDROXYANISOLE
|
Others | Others |
3-TERT-BUTYL-4-HYDROXYANISOLE 是一种抗氧化剂,通过水氯化生产。 | |||
T37538 |
Amifostine thiol
|
||
Amifostine thiol (WR-1065), the active metabolite of cytoprotector Amifostine, serves as a cytoprotective agent possessing radioprotective properties. It activates p53 via a JNK-dependent signaling pathway[1][2][3]. | |||
T3644 |
U93631
|
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
U93631 是一种具有新型化学结构的 GABAA 受体配体,IC50 为 100 nM,它在重组 GABAA 受体中诱导 GABA 诱导的全细胞 Cl 电流快速,这种效果随时间依赖性衰减。 | |||
T39980 |
ErSO
|
Others | Others |
ErSO 是一种通过 ERα 受体的,预期未折叠蛋白反应 (UPR) 的特异性激活剂。 ErSO 可用于抗癌研究。 | |||
T8694 |
ML406
|
Antibacterial; Antibiotic | Microbiology/Virology |
ML406 是一种小分子探针,通过抑制M.tuberculosisBioA(DAPA 合酶) 显示出抗结核活性,IC50为 30 nM。 | |||
T9212 |
IMB-301
|
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
IMB-301是根据 hA3G 模型通过虚拟筛选的一种小分子抑制剂。 | |||
T4216 |
STAT5-IN-1
STAT5 Inhibitor |
STAT | JAK/STAT signaling; Stem Cells |
STAT5-IN-1 (STAT5 Inhibitor) 是STAT5的抑制剂,对 STAT5β 亚型的IC50值为 47 μM。 | |||
T8400 |
Pamidronic acid
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Pamidronic acid 可用于各种骨吸收类疾病的研究。 | |||
T34262 |
RAPTA-C
|
Apoptosis | Apoptosis |
RAPTA-C 可通过线粒体和 p53-JNK 途径诱导 EAC 细胞周期停滞和凋亡,可用于研究乳腺癌和卵巢癌。 | |||
T15069 |
DBCO-PEG4-Biotin
ADIBO-NH-PEG2-Biotin |
Others | Others |
DBCO-PEG4-Biotin (ADIBO-NH-PEG2-Biotin) 是一种 azadibenzocyclooctyne-biotin 衍生物,含有生物素基团和 4 个 PEG。DBCO-PEG4-Biotin 是一种用途广泛的生物素酰化试剂,能通过无铜催化烷基叠氮化反应 (SPAAC) 将生物素的一部分引入叠氮标记的生物分子中。 | |||
T4377 |
Pimodivir
VX-787 |
Influenza Virus | Microbiology/Virology |
Pimodivir (VX-787) 是一种通过口服的甲型流感病毒聚合酶抑制剂,与病毒 PB2 亚基相互作用。 | |||
T0168 |
Estradiol (cypionate)
Depofemin,环戊丙酸雌二醇,Estradiol cypionate |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Estradiol cypionate (Depofemin) 是一种 Estradiol 的 17β-环戊丙酸酯,能够作用于雌激素受体。抑制ET-1的合成。 | |||
T24733 |
Roxifiban acetate
MK 0853,DMP754,DMP 755,DMP 754 acetate,DMP 754,DMP-754 acetate,DMP754 acetate,DMP-754 |
Integrin | Cytoskeletal Signaling |
Roxifiban acetate(DMP 754 acetate) 是一种有效的GP IIb / IIIa拮抗剂,通过免疫介导展现出抗血小板聚集活性,可用于研究人类血小板减少症。 | |||
T7428 |
SBI-115
|
GPCR19 | GPCR/G Protein |
SBI-115 是TGR5 (GPCR19)拮抗剂,对 TGR5 降低多囊性肝病的肝囊肿形成具有抑制作用。 | |||
TP1345 |
Kisspeptin-10, human (TFA)(374675-21-5,FREE)
|
GPR; Kisspeptin | Endocrinology/Hormones; GPCR/G Protein |
Kisspeptin-10, human (TFA)(374675-21-5,FREE) 是一种有效的血管收缩剂和血管生成抑制剂。 Kisspeptin-10,人类 TFA 通过其受体 GPR54 充当肿瘤转移抑制因子。 Kisspeptin-10-GPR54系统在胚胎肾发育中发挥重要作用。 Kisspeptin-10/GPR54 信号通过 NFATc4 介导的 BMP2 表达诱导成骨细胞分化 | |||
T9015 |
LY900009
|
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
LY900009 是一种通过选择性抑制 γ-分泌酶蛋白来抑制 Notch 信号传导的小分子抑制剂。 | |||
T6344 |
Sevelamer hydrochloride
Sevelamer HCl |
FXR; Autophagy | Autophagy; Metabolism |
Sevelamer hydrochloride (Sevelamer HCl) 是一种磷酸盐结合药物,用于通过与膳食磷酸盐结合并阻止其吸收来治疗高磷血症。 | |||
T20689 |
Temocaprilat
RNH-5139,RS-5139,RNH 5139,RNH5139,替莫普利,RS5139,RS 5139 |
Angiotensin-converting Enzyme (ACE) | Metabolism |
Temocaprilat (RS5139) 是一种血管紧张素转换酶 (ACE) 抑制剂。 Temocaprilat 通过缺乏 EHBR 的 cMOAT 有效地从胆汁中排泄,而许多其他 ACE 抑制剂对 cMOAT 的亲和力较低。 | |||
T28077 |
MMPP
|
VEGFR; STAT | Angiogenesis; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
MMPP 是一种新型 VEGFR2 抑制剂,具有抗炎活性和潜在的抗癌活性,抑制STAT3 ,可通过 VEGFR2/AKT/ERK/NF-kappaB 通路抑制血管生成,可用于缓解心肌损伤。 | |||
T4055 |
Etoxazole
|
Others | Others |
Etoxazole 是一种杀螨剂/杀虫剂,通过抑制几丁质生物合成来控制螨虫。用作农药检测的标准。 | |||
T19596 |
UDP-GlcNAc Disodium Salt
Uridine 5′-diphospho-N-acetylglucosamine,5′-二磷酸尿嘧啶核苷-N-乙酰半乳糖胺二钠盐,UDP-α-D-N-Acetylglucosamine Disodium Salt |
Others | Others |
UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) 是一种 O-GlcNAc 转移酶 (OGT) 的供体底物。 | |||
T0313 |
Evans blue
Direct Blue 53,C.I. 23860,伊文思蓝 |
GluR | Neuroscience |
Evans blue (C.I. 23860) 是一种突触泡谷氨酸吸收的有效抑制剂,同时也是一种AMPA/kainate 受体拮抗剂。 | |||
T3995 |
Amcasertib
安卡舍替,BBI503 |
Stemness kinase | Stem Cells |
Amcasertib (BBI503) 是一种cancer stemness kinase 抑制剂,抑制Nanog 和其他癌症干细胞通路,具有潜在的抗癌活性。 | |||
T27439 |
GS-9667
CVT-3619,CVT 3619 |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
GS-9667是一种A(1)腺苷受体(AR)的选择性部分激动剂,通过降低游离脂肪酸(FFA)可有效治疗2型糖尿病(T2DM)和血脂异常。 | |||
T27303 |
Farglitazar
GI-262570,GI-2570,GW 262570X,GI 262570,GI262570 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Farglitazar (GI-262570) 是一种 PPAR-γ 激动剂,是胰岛素增敏剂,通过氧化物酶体增殖物激活受体γ,抑制星状细胞活化,可用于研究糖尿病。 | |||
T27094 |
CT-2584
CT2584 |
||
CT-2584 is an angiogenesis inhibitor and lysophosphatidic acid acyltransferase inhibitor. CT-2584 inhibits phospholipid signaling. By inhibiting CTP:choline-phosphate cytidylyltransferase (CT), CT-2584 caused de novo phospholipid biosynthesis via PA to be | |||
T34399 |
Rovatirelin
KPS-0373,S0373,S-0373,S 0373 |
AChE | Neuroscience |
Rovatirelin (S-0373) 是一种新合成的促甲状腺激素释放激素(TRH)类似物,通过乙酰胆碱和多巴胺神经传递改善胞嘧啶阿拉伯糖苷诱导的脊髓小脑变性大鼠模型的运动功能障碍。 | |||
TP2030L1 |
Gastrin I (human) acetate
Gastrin I (human) acetate(10047-33-3 free base),Gastrin-17 acetate,Little gastrin I acetate,胃膜素醋酸盐 |
cholecystokinin | GPCR/G Protein |
Gastrin I (human) acetate (Gastrin-17 acetate) 是在胃中产生的内源性肽,通过胆囊收缩素 2 (CCK2) 受体增加胃酸分泌。 | |||
T29955 |
AMC-01
AMC01,AMC 01 |
Antiviral; PERK | Apoptosis; Immunology/Inflammation |
AMC-01 具有潜在的抗病毒活,可通过丝氨酸残基 51 的磷酸化诱导 eIF2-α 失活,这种作用具有剂量和时间依赖性。AMC-01 可用来研究动脉粥样硬化和帕金森综合征。 | |||
T18595 |
Dasatinib carbaldehyde
PROTAC ABL binding moiety 4,BMS-354825 carbaldehyde |
Others; Ligands for Target Protein for PROTAC | Others; PROTAC |
Dasatinib carbaldehyde (PROTAC ABL binding moiety 4) 基于 ABL 抑制剂达沙替尼,通过接头与 IAP 配体结合,形成 SNIPER [1]。 | |||
T5128 |
RGX-104 hydrochloride
SB742881,RGX-104 HCl,盐酸RGX-104 |
Liver X Receptor | Metabolism |
RGX-104 hydrochloride (SB742881) 是小分子LXR 激动剂,利用 ApoE 基因的转录激活,调节先天免疫。 | |||
T6191 |
Tasisulam
LY573636,他司磺胺 |
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
Tasisulam (LY573636) 是一种小分子抗肿瘤药物,通过内在途径诱导细胞凋亡,导致细胞色素 c 释放和 caspase 依赖性细胞死亡。它抑制有丝分裂进程并诱导血管正常化。 | |||
TP2030 |
Gastrin I, human
Gastrin I (human) |
cholecystokinin | GPCR/G Protein |
Gastrin I, human (Gastrin I (human)) 是胃中产生的内源性肽,通过 CCK2 受体增加大鼠的胃蛋白酶原和酸分泌。 | |||
T0893 |
Tinidazole
替硝唑,CP12574 |
Antibacterial; Antibiotic | Microbiology/Virology |
Tinidazole (CP12574) 是一种对厌氧菌和原生动物具有选择性抗菌活性的 5-硝基咪唑,是一种具有口服活性的抗菌剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2175 |
Salvianolic acid F
丹酚酸F,丹酚酸 F |
Caspase | Apoptosis; Proteases/Proteasome |
The role of our hybrid molecules, an analogue of Salvianolic acid F, in compelling the glioma cells towards apoptosis by specifically perturbing the concentration of glutathione along with caspase 6. | |||
T6S0444 |
Salvianolic acid A
丹酚酸 A,Dan Phenolic Acid A |
MMP | Proteases/Proteasome |
Salvianolic acid A (Dan Phenolic Acid A) 能够提高抑制基质金属钛酶 9 和抗炎作用,进而保护血脑屏障。 | |||
TN6789 |
Neosalvianen
|
Others | Others |
Neosalvianen 是从丹参中分离出来的。 | |||
T4589 |
9'''-Methyl salvianolate B
9’’’-丹酚酸B单甲酯,9'''-丹酚酸B单甲酯,9'''-MethyllithosperMate B |
Others | Others |
9'''-MethyllithosperMate B 是一种从 Cynoglossum columnaeTen 中获得的一种天然提取物。 | |||
T3208 |
Brevianamide F
Cyclo-L-tryptophyl-L-proline,cyclo-(L-Trp-L-Pro),Cyclo(L-Pro-L-Trp) |
BCRP; PI3K; Antibacterial | Membrane transporter/Ion channel; Microbiology/Virology; PI3K/Akt/mTOR signaling |
Brevianamide F (Cyclo(L-Pro-L-Trp)) 是一种从Colletotrichum gloeosporioides 中分离得到的真菌毒素,属于天然存在的 2,5-二酮哌嗪类,具有抗菌活性。它具有PI3Kα抑制活性,IC50值为 4.8 µM。 | |||
TN2173 |
Salvianolic acid D
(R,E)-2-((3-(2-(carboxymethyl)-3,4-dihydroxyphenyl)acryloyl)oxy)-3-(3,4-dihydroxyphenyl)propanoic acid,丹酚酸D,丹酚酸 D |
Others | Others |
Salvianolic acid D ((R,E)-2-((3-(2-(carboxymethyl)-3,4-dihydroxyphenyl)acryloyl)oxy)-3-(3,4-dihydroxyphenyl)propanoic acid) 是一种分离自Salvia miltiorrhiza 中的化合物,有潜在抗血小板作用。 | |||
T3149 |
Salvianolic Acid C
丹酚酸C,丹酚酸 C |
Others; P450 | Metabolism; Others |
Salvianolic acid C 是一种细胞色素 P4502C8(CYP2C8)的非竞争性抑制剂及细胞色素 P4502J2(CYP2J2)中等强度的混合抑制剂,对 CYP2C8 和 CYP2J2 的 Ki 分别为 4.82 μM 和 5.75 μM。 | |||
TN1127 |
Salviaflaside
|
Antioxidant | oxidation-reduction |
Salviaflaside 是夏枯草的主要生物活性成分,具有抗氧化活性。 | |||
T2727 |
Salvianolic acid B
|
Others | Others |
Salvianolic acid B (Dan Shen Suan B) 是一种来自丹参提取物的水溶性抗氧化剂,具有抗血小板聚集、抗凝和抗血栓作用。它常用来研究微循环疾病。 | |||
T4961 |
9''-Methyl salvianolate B
9'-Methyl lithospermate B,9’-丹酚酸B单甲酯,9''-丹酚酸B单甲酯 |
Others | Others |
9'-Methyl lithospermate B 是一种酚类化合物,提取自 RadixSalvia miltiorrhizae。 | |||
TN2174 |
Salvianolic acid E
丹酚酸 E,丹酚酸E |
Others | Others |
Salvianolic acid E 是一种从丹参 Salvia miltiorrhiza 中分离出来的水溶性成分。 | |||
T5725 |
Salvianolic acid B
丹酚酸B,lithospermic acid B,Dan Shen Suan B |
Sirtuin; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Salvianolic acid B (Dan Shen Suan B) 是一种来自丹参提取物的水溶性抗氧化剂,具有抗血小板聚集、抗凝和抗血栓作用。它常用来研究微循环疾病。 | |||
TN5678 |
Salviaplebeiaside
|
||
Salviaplebeiaside is a natural product from Vitex negundo var. cannabifolia. | |||
T75553 |
Salvianan A
|
||
1,6,11-Trimethyl-1,2-dihydrofuro[2',3':1,2]phenanthro[4,3-d]oxazole (compound 1) 是一种有效的抗HIV-1剂。 | |||
T82818 |
Brevianamide R
|
||
Brevianamide R (compound 4) 是从发酵大米中的曲霉菌 (Aspergillus versicolor) 分离出的生物碱。 | |||
TN4935 |
Salvianolic acid Y
|
Others | Others |
Salvianolic acid Y 从丹参 Salvia officinalis 中分离出来,是 PC12 细胞免受过氧化氢诱导的丹参损伤的保护剂。 | |||
T39825 |
(Rac)-Salvianic acid A
(Rac)-丹参素,(Rac)-Danshensu |
||
(Rac)-Salvianic acid A, also known as (Rac)-Danshensu, is a phenolic acid compound that possesses exceptional radical scavenging and antioxidant properties. | |||
TN1801 |
Isosalvianolic acid C
|
LDL | Metabolism |
Isosalvianolic acid C exhibits more potent activity than probucol except for salvianolic acid F . | |||
T79986 |
Brevianamide M
|
||
Brevianamide M (compound 4)为Aspergillus versicolor代谢物,该物质源自海洋褐藻Ecklonia马尾藻中分离的内生真菌。Brevianamide M展示出针对大肠杆菌和金黄色葡萄球菌的抗菌活性。 | |||
T83278 |
6,7-Dihydrosalviandulin E
|
||
6,7-Dihydrosalviandulin E为新型的氯烷类二萜,可从鼠尾草(Salvia)地上部分提取。 | |||
TN2451 |
Isosalvianolic acid B
|
NF-κB | NF-κB |
Isosalvianolic acid B is a natural from Salviae miltiorrhizae | |||
TN4812 |
Pluviatolide
|
AChR | Neuroscience |
(-)-Pluviatolide can inhibit electrically-induced and acetylcholine-induced contraction in the isolated guinea-pig ileum. | |||
T82819 |
Brevianamide Q
|
||
Brevianamide Q (Compound 3),一种Aspergillus versicolor产生的生物碱。 | |||
T75617 | Salviandulin E | ||
Salviandulin E 是一种二萜类化合物,可从墨西哥鼠尾草中分离。Salviandulin E 显示出对 T. b. bruceiGUTat 3.1寄生虫 (parasites) 的抗锥虫体活性,IC50值为 0.72 µg/mL。 | |||
TN6498 |
Stevia impurity (13-[(2-O-6-deoxy-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester)
|
||
Stevia impurity (13-[(2-O-6-deoxy-β-D-glucopyranosyl-3-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester) 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6498,CAS号为 1309929-72-3。 | |||
T4853 |
TRIA-662
3-Carbamoyl-1-methylpyridinium Chloride,3-氨基甲酰-1-甲基氯化吡啶,1-Methylnicotinamide chloride,1-methylpyridin-1-ium-3-carboxamide hydrochloride,Nicotinamide Chloromethylate |
Others; Endogenous Metabolite | Metabolism; Others |
TRIA-662 (Nicotinamide Chloromethylate) 是内源性代谢产物的一种。 | |||
T3345 |
Hederasaponin B
常春藤皂苷B,Eleutheroside M,刺五加叶中,Hederacoside B |
Others; Virus Protease | Microbiology/Virology; Others |
Hederasaponin B (Hederacoside B) 是从Hedera helix 中分离的,有广谱抗病毒活性。 | |||
T3797 |
Isosilybin
Isosilybinin,Isosilibinin,异水飞蓟宾,Silymarin,Silybin B,Q-100795 |
P450 | Metabolism |
Isosilybin (Isosilibinin) 是一种类黄酮,来源于乳蓟;能够抑制CYP3A4诱导(IC50:74 μM)。 | |||
T3890 |
Verbenalin
Verbenalol β-D-glucopyranoside,马鞭草苷,Verbenaloside,Verbenalol glucoside,Cornin |
Others | Others |
Verbenalin (Verbenaloside) 是马鞭草苷,具有抗炎、抗真菌、抗病毒等活性。它能减轻脑缺血再灌注损伤。它可用于前列腺炎的研究。 | |||
T7028 |
Licochalcone C
LICOCHALCONEC,甘草查尔酮C |
Phosphatase; Antioxidant; Glucosidase | Metabolism; oxidation-reduction |
Licochalcone C (LICOCHALCONEC) 能够抑制 α-葡萄糖苷酶,其对 α-葡萄糖苷酶的 IC50 <100 nM,对蛋白酪氨酸磷酸酶 1B 的 IC50=92.43 μM 。 | |||
T5S0053 |
Coptisine
黄连碱,Coptisin |
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
Coptisine (Coptisin) 是一种从黄连中分离到的生物碱,是非竞争性的IDO 抑制剂,Ki=为 5.8 μM,IC50=6.3 μM。 | |||
TN1836 |
Kudinoside D
|
LDL; AMPK; PPAR | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling |
Kudinoside D 是 Ilex kudingcha 中三萜皂苷的主要天然成分之一。它能够调节 3T3-L1 脂肪细胞中 AMPK 途径,并可抑制脂肪形成。 | |||
T4733 |
Sucrose
D(+)-Sucrose,D-(+)-Saccharose,蔗糖 |
Others; Endogenous Metabolite | Metabolism; Others |
Sucrose (D-(+)-Saccharose) 是一种二糖,由果糖和葡萄糖组成。Sucrose 能够应用于一些动物模型,包括代谢性疾病、偏食、肥胖、糖尿病等。 | |||
T2911 |
Stevioside
甜菊苷,蛇菊苷 |
TLR | Immunology/Inflammation |
Stevioside 是一种天然甜味剂,从甜叶菊叶中提取的获得,具有抗癌作用。 | |||
TN6771 |
Malabaricone B
|
Others | Others |
Malabaricone B 是一种源自香料的酚类物质,它通过不依赖 p53 的途径诱导肺癌细胞中的线粒体损伤。 | |||
T5S1261 |
Methylophiopogonanone B
|
Ras | GPCR/G Protein; MAPK |
Methylophiopogonanone B 是一种高异二氢黄酮,提取自麦冬的根,抗氧化能力强,它通过 Rho 信号传导途径及增加 GTP-Rho 发挥效果。它能够重组肌动蛋白细胞骨架,使细胞形态(如树突收缩、应力纤维形成)发生变化。 | |||
TN4114 |
Gardenin A
|
ERK; LDL; MAPK; PKA; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Metabolism; Tyrosine Kinase/Adaptors |
Gardenin A 通过激活 MAPK/ERK、PKC 和 PKA 表现出神经营养作用。 Gardenin A 具有抗抑郁、抗惊厥和抗焦虑作用。 | |||
TN4661 |
Nodosin
|
IL Receptor; Autophagy | Autophagy; Immunology/Inflammation |
Nodosin 是一种二萜化合物,从Isodon trichocarpusKudo 和I. JaponicusHARA 中提取得到。 | |||
T8030 |
Ethyl pyruvate
|
Apoptosis; Antioxidant | Apoptosis; oxidation-reduction |
Ethyl pyruvate 是一种内源性代谢物丙酮酸的衍生物,是一种抗炎剂。 | |||
T9294 |
DL-Valine
DL-缬氨酸,Valine, DL-,H-DL-Val-OH,2-Amino-3-methylbutanoic acid |
Others | Others |
DL-Valine (H-DL-Val-OH) 是 2-氨基-3-甲基丁酸。它是在植物中从丙酮酸开始通过几个步骤合成的。 | |||
T4S1578 |
Nystose
1,1-Kestotetraose,耐斯糖,Fungitetraose,蔗果四糖 |
Others | Others |
Nystose (1,1-Kestotetraose) 是四糖,由两个果糖分子通过 β (1→2) 键与蔗糖的果糖基部分连接而成。 | |||
T6S1367 |
Procyanidin B2
原花青素 B2,Proanthocyanidin B2 |
Reactive Oxygen Species; NOD | Immunology/Inflammation; Metabolism; NF-κB |
Procyanidin B2 (Proanthocyanidin B2) 是天然黄酮类物质,具有抗肿瘤,抗氧化等活性。 | |||
T3397 |
Epmedin C
淫羊霍定C,Baohuoside-VI,Epimedin C |
Others | Others |
Epmedin C (Baohuoside-VI) 是天然化合物,在切除卵巢的小鼠体内与雌性激素作用相似。 | |||
TMS2171 |
(±)-Naringenin
(±)-柚皮素,Salipurpol,柚皮素,Naringenine,Naringenin |
Potassium Channel | Membrane transporter/Ion channel |
(±)-Naringenin (Naringenine) 是一种天然的类黄酮。它通过激活肌细胞中 BKCa 通道发挥对内皮剥脱血管的舒张作用。 | |||
T3896 |
Shanzhiside methyl ester
三栀子甙甲酯,山芝皂苷甲酯 |
Glucagon Receptor | GPCR/G Protein |
Shanzhiside methyl ester 是一种小分子胰高血糖素样肽 1 受体激动剂,分离自轮状乳杆菌,能够诱导抗异常性痛觉耐受。 | |||
T5S0168 |
Atractylenolide II
2-Atractylenolide,Asterolide,苍术内酯II |
Apoptosis; ERK; p38 MAPK; Akt; STAT | Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells |
Atractylenolide II (2-Atractylenolide) 是一种从白术干燥根茎分离的倍半萜类天然产物,具有抗增殖活性。 | |||
TN2081 |
Maohuoside A
|
MAPK | MAPK |
Maohuoside A 是从 E. koreanum 中分离出的单一化合物,具有促进成骨作用。它能够利用 MAPK 信号通路骨及形态发生蛋白 (BMP) ,促进骨髓间充质干细胞的成骨作用。 | |||
T7851 |
Tyramine hydrochloride
盐酸酪胺,酪胺盐酸盐 |
Others; Endogenous Metabolite | Metabolism; Others |
Tyramine hydrochloride 是一种氨基酸,有助于调节血压。其中 Tyramine 天然存在于体内,并存在于某些食物中。 | |||
T4738 |
Sodium 2-hydroxybutanoate
2-Hydroxybutyric acid sodium salt,2-羟基丁酸钠,DL-2-Hydroxybutyric Acid Sodium Salt,alpha-hydroxybutyrate,SODIUM 2-HYDROXYBUTYRATE |
Others; Endogenous Metabolite | Metabolism; Others |
Sodium 2-hydroxybutanoate (alpha-hydroxybutyrate) 是内源性代谢产物的一种。 | |||
T4709 |
(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride
盐酸 D-甘露糖胺,D-Mannosamine hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
(2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride (D-Mannosamine hydrochloride) 是内源性代谢产物的一种。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01843 |
SEMA6A Protein, Human, Recombinant (His)
HT018,VIA,sema domain, transmembrane domain (TM), a... |
Human | HEK293 Cells |
SEMA6A, the first identified class 6 semaphorin, is contributed to regulate vascular development and adult angiogenesis. SEMA6A could inhibit proliferation, migration, and invasion in different glioma cell lines. That SEMA6A may be a potential prognostic biomarker in the treatment of GBM. Among different semaphorins tested by reverse transcriptase-polymerase chain reaction in human immune cells, the expression of class 6 transmembrane semaphorin SEMA6A was restricted to dendritic cells (DCs). | |||
TMPY-05141 |
BETVIA Protein, Betula pendula, Recombinant
|
Betula pendula | E. coli |
BETVIA Protein, Betula pendula, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.6 kDa and the accession number is P15494.2. | |||
TMPJ-00640 |
CTLA-4 Protein, Cavia porcellus, Recombinant (His)
Cytotoxic T-lymphocyte protein 4,CTLA4,Cytotoxic T-lymphocyt... |
Cavia porcellus | P. pastoris (Yeast) |
CTLA-4 Protein, Cavia porcellus, Recombinant (His) is expressed in P. pastoris yeast expression system with C-6xHis tag. The predicted molecular weight is 18-40 KDa and the accession number is H0VUB1. | |||
TMPY-05888 |
Influenza A H1N1 (A/Pavia/65/2016) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H1N1 | HEK293 Cells |
Influenza A H1N1 (A/Pavia/65/2016) Hemagglutinin/HA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59 kDa and the accession number is A0A1L6YSP8. | |||
TMPJ-01392 |
IL-1 beta/IL-1F2 Protein, Cavia porcellus, Recombinant (His)
IL-1 β,IL1B,IL-1 beta,Interleukin-1 β,Interleukin-1 beta |
Cavia porcellus | E. coli |
Interleukin-1 beta (IL1B) belongs to the IL-1 family. Interleukin 1 (IL-1) is a family of polypeptide cytokines consisting of two agonists, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2) encoded by two distinct genes and perform identical biological functions. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response. It is identified as endogenous pyrogens, and... | |||
TMPJ-00261 |
TGF beta 2 Protein, Mouse/Rat, Recombinant
transforming growth factor β-2,BSC-1 cell growth inhibitor,G... |
Mouse,Rat | HEK293 Cells |
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the n... | |||
TMPH-02151 |
OXCT1 Protein, Human, Recombinant (His)
|
Human | E. coli |
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. OXCT1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 56.1 kDa and the accession number is P55809. | |||
TMPJ-01468 |
pro-Beta NGF Protein, Human, Recombinant
β-NGF,NGF,NGFB,Beta-NGF,Beta-Nerve Growth Factor,pro-Beta NG... |
Human | E. coli |
The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystin knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration. | |||
TMPK-00735 |
CXCL13/BCA-1 Protein, Mouse, Recombinant (His)
ANGIE,BLR1L,ANGIE2,BLC,SCYB13,BCA1,BCA-1 |
Mouse | HEK293 Cells |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The pred... | |||
TMPK-00678 |
CALCA/CGRP Protein, Mouse, Recombinant (hFc)
CGRP,Katacalcin,PDN-21,CGRP-I,CGRP1,Calcitonin 1,Calcitonin,... |
Mouse | HEK293 Cells |
Specific fragments of methylation changes in the target gene (Calca) were identified by IGV analysis. CGRP was applied to compare the effects on ASCs-T2DM morphology via phalloidin staining, proliferation through CCK-8 assay, and osteogenic differentiation with osteogenic staining, qPCR, and repair of calvarial defect. Furthermore, 5-azacytidine (5-az) was used to intervene ASCs-T2DM to verify the relationship between the methylation level of the target fragment and expression of Calca. | |||
TMPH-00010 |
MMP-14 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to... | |||
TMPY-03958 |
TGF alpha Protein, Human, Recombinant
transforming growth factor α,转化生长因子,transforming growth fact... |
Human | E. coli |
The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared to adjacent normal tissue and high TGFA gene expression strongly correlated with poor survival in patients with lung adenocarcinoma, and miR-374a suppresses lung adenocarcinoma cell proliferation and invasion via targeting TGFA gene expression. Transforming growth factor alpha (... | |||
TMPK-00474 |
IL-22RA1 Protein, Cynomolgus, Recombinant (His)
CRF2-9,IL22R1,IL-22R-α-1,IL-22RA1,zcytoR11,IL22R,IL-22R-alph... |
Cynomolgus | HEK293 Cells |
IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activatio... | |||
TMPJ-00166 |
SCF Protein, Mouse, Recombinant
SCF,Hematopoietic growth factor KL,MGF,Steel factor,Mast cel... |
Mouse | E. coli |
Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the ... | |||
TMPY-00395 |
Insulin Protein, Human, Recombinant
IDDM1,MODY10,ILPR,IDDM2,IRDN,IDDM,insulin,INS |
Human | P. pastoris (Yeast) |
INS (Insulin) is a Protein Coding gene. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. The binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Diseases associated with ... | |||
TMPJ-00059 |
IL-7 Protein, Human, Recombinant (His)
Interleukin-7,IL7,白细胞介素,IL-7,白介素 |
Human | HEK293 Cells |
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-spe... | |||
TMPY-05004 |
FGF-4 Protein, Human, Recombinant
HST-1,KFGF,fibroblast growth factor 4,HSTF1,K-FGF,HST,HBGF-4 |
Human | E. coli |
FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) a... | |||
TMPY-02157 |
GST Protein, Schistosoma japonicum, Recombinant
|
Schistosoma japonicum | Baculovirus Insect Cells |
Genetic engineers have used glutathione S-transferase to create the GST gene fusion system. This system is used to purify and detect proteins of interest. In a GST gene fusion system, the GST sequence is incorporated into an expression vector alongside the gene sequence encoding the protein of interest. Induction of protein expression from the vector's promoter results in expression of a fusion protein: the protein of interest fused to the GST protein. This GST-fusion protein can then be purifie... | |||
TMPY-02115 |
R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His)
CRISTIN1,THSD2,R-spondin 3,PWTSR |
Human | HEK293 Cells |
R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. The four members have high structural homology. RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. All RSPO members require Wnt ligands and LRP6 for activity and amplify s... | |||
TMPY-02904 |
TLR4 Protein, Human, Recombinant (His)
TLR-4,TOLL,toll-like receptor 4,ARMD10,TLR4,CD284 |
Human | Baculovirus Insect Cells |
TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR4 is most abundantly expressed... | |||
TMPJ-00865 |
VEGF121 Protein, Human, Recombinant (His)
VEGFA,VEGF-A,Vascular permeability factor,VPF,血管内皮生长因子,Vascu... |
Human | HEK293 Cells |
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel... | |||
TMPJ-00994 |
LTBR Protein, Mouse, Recombinant (hFc)
Tnfcr,Lymphotoxin-beta receptor,Tumor necrosis factor recept... |
Mouse | HEK293 Cells |
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs... | |||
TMPY-05176 |
AMH Protein, Human, Recombinant (His)
MIS,anti-Mullerian hormone,MIF |
Human | HEK293 Cells |
Anti-Mullerian hormone (AMH), a member of the TGF-beta superfamily, is produced by granulosa cells (GCs) of preantral and small antral follicles and plays a role in regulating the recruitment of primordial follicles and the FSH-dependent development of follicles. BMP15 up-regulates the transcription of AMH and that the inhibition of p38 MAPK decreases the BMP15-induced expression of AMH and SOX9, suggesting that BMP15 up-regulates the expression of AMH via the p38 MAPK signaling pathway, and thi... | |||
TMPY-01085 |
VLDLR Protein, Human, Recombinant (His)
VLDLRCH,CAMRQ1,CHRMQ1,very low density lipoprotein receptor,... |
Human | HEK293 Cells |
The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and ApoER2, and is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar sdomain. VLDLR contains 3 EGF-like domains, 8 LDL-receptor class A domains, as well as 6 LDL-receptor class B repeats, and is ... | |||
TMPY-01648 |
TREML2 Protein, Human, Recombinant (His)
TLT2,dJ238O23.1,triggering receptor expressed on myeloid cel... |
Human | HEK293 Cells |
Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like) domain. TREML2 is detected in cultured B cells, T cell leukemia and monocyte leukemia. TREML2 is expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. TREML2 is a cell surface receptor that may play a role in the innate and adaptive immune respons... | |||
TMPJ-00042 |
TSLP Protein, Human, Recombinant
TSLP,Thymic stromal lymphopoietin |
Human | E. coli |
Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino acids (aa) signal sequence and 131 aa mature region. Human TSLP has two isoforms lfTSLP and sfTSLP produced by alternative splicing . lfTSLP is expressed in a number of tissues including heart, liver and prostate, and sfTSLP (63aa) is predominantly expressed in keratinocytes of oral... | |||
TMPY-02245 |
SNAP-25 Protein, Human, Recombinant (His)
synaptosomal-associated protein, 25kDa,SEC9,SNAP,RIC-4,dJ106... |
Human | E. coli |
Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25 / SUP contains 2 t-SNARE coiled-coil homology domains. SNAP25 / SUP is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 / SUP protein is a component of the SNARE complex, which is proposed to account for the sp... | |||
TMPH-01513 |
IGIP Protein, Human, Recombinant (His & KSI)
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Human | E. coli |
Enhances IgA secretion from B-cells stimulated via CD40. | |||
TMPH-01514 |
IGIP Protein, Human, Recombinant (His & TF)
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Human | Baculovirus Insect Cells |
Enhances IgA secretion from B-cells stimulated via CD40. | |||
TMPH-03587 |
GspB Protein, S. gordonii, Recombinant (GST)
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Streptococcus gordonii | E. coli |
Plays a role in virulence and host-pathogen interactions. Mediates binding to human platelets via interaction with the human cell surface glycoprotein GP1BA. Plays a positive role in biofilm formation, possibly by self-association via the basic region (BR). GspB Protein, S. gordonii, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 68.5 kDa and the accession number is Q939N5. | |||
TMPH-03265 |
CMKLR2 Protein, Rat, Recombinant (His)
Chemerin chemokine-like receptor 2,Gpr1,Chemokine-like recep... |
Rat | E. coli |
Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis. Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway. | |||
TMPK-00109 |
Artemin Protein, Human, Recombinant (hFc)
ARTNE,ARTN,Neublastin,Enovin,Artemin,NBN,EVN |
Human | HEK293 Cells |
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored GDNF family receptors a (GFRa1, GFRa3) and RET receptor tyrosine kinase. The major mechanism of ARTN action is via binding to a non-signaling co-receptor. The major function of ARTN is to drive the molecule to induce migration and axonal projection from sympathetic neurons. | |||
TMPH-01621 |
BRCC3 Protein, Human, Recombinant (His & SUMO)
BRCC36,CXorf53,C6.1A,BRCC3,BRCA1/BRCA2-containing complex su... |
Human | E. coli |
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, anta... | |||
TMPK-00958 |
BTN1A1 Protein, Human, Recombinant (His & Avi)
BT,BTN,Butyrophilin,BTN1A1 |
Human | HEK293 Cells |
Butyrophilin 1A1 (BTN1A1) is one of the membrane proteins that surrounds LD,BTN1A1 plays an important role in regulating LD synthesis via a mechanism involving membrane phospholipid composition. | |||
TMPH-01201 |
DRD2 Protein, Human, Recombinant (His & Myc)
Dopamine D2 receptor,D(2) dopamine receptor,DRD2 |
Human | E. coli |
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5. | |||
TMPJ-01368 |
GPC1 Protein, Mouse, Recombinant (His)
Gpc1,Glypican-1 |
Mouse | HEK293 Cells |
Glypican-1 is a cell membrane protein and belongs to the glypican family. The protein may act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. It is required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated sig... | |||
TMPH-00521 |
G3P Protein, Enterobacteria phage M13, Recombinant (His)
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Enterobacteria phage M13 | P. pastoris (Yeast) |
Plays essential roles both in the penetration of the viral genome into the bacterial host via pilus retraction and in the extrusion process. During the initial step of infection, G3P mediates adsorption of the phage to its primary receptor, the tip of host F-pilus. Subsequent interaction with the host entry receptor tolA induces penetration of the viral DNA into the host cytoplasm. In the extrusion process, G3P mediates the release of the membrane-anchored virion from the cell via its C-terminal... | |||
TMPJ-00800 |
BPGM Protein, Human, Recombinant (His)
3-Diphosphoglycerate Mutase,2,DPGM,Bisphosphoglycerate Mutas... |
Human | E. coli |
Bisphosphoglycerate Mutase (BPGM) is a member of the Phosphoglycerate Mutase family and BPG-Dependent PGAM subfamily. BPGM is a multifunctional enzyme. BPGM catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. It also has phosphoglycerate phosphomutase activity. BPGM plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of 2,3-bisphosphoglycerate (2,3-BPG). Deficiency of BPGM increases the affinity of cells... | |||
TMPK-00062 |
CD160 Protein, Human, Recombinant (His & Avi)
BY55FLJ46513,NK28,NK1, BY55,CD160 |
Human | HEK293 Cells |
CD160 (also Natural killer cell receptor BY55) is a 27 ‑ 30 kDa member of the Ig superfamily. In human, it is expressed principally on nonmyeloid hematopoietic cells. CD160 antigenis a receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta... | |||
TMPJ-01050 |
GRB2 Protein, Human, Recombinant (His)
Growth Factor Receptor-Bound Protein 2,SH2/SH3 Adapter GRB2,... |
Human | E. coli |
As an adaptor protein, Growth Factor Receptor-Bound Protein 2 (GRB2) is involved in siganl transduction and consists of a central SH2 domain flanked by two SH3 domains. GRB2 associates with activated Tyr-phosphorylated EGF receptor/EGFR and PDGF receptors via its SH2 domain, stimulating GTP binding to Ras, which in turn activates MAPK and other signaling pathway.It also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK. probably via the concerted acti... | |||
TMPH-02675 |
GCGR Protein, Mouse, Recombinant (GST)
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Mouse | E. coli |
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. ... | |||
TMPH-02373 |
Metallo-beta-lactamase type 2 Protein, Klebsiella pneumoniae, Recombinant (His)
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Klebsiella pneumoniae | E. coli |
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. | |||
TMPH-03365 |
REG3A Protein, Rat, Recombinant (E.coli, His)
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Rat | E. coli |
Bactericidal C-type lectin. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. REG3A Protein, Rat, Recombinant (E.coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.5 kDa and the accession number is P35231. | |||
TMPH-00156 |
Ribonuclease Protein, Bacillus amyloliquefaciens, Recombinant (His)
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Bacillus amyloliquefaciens | E. coli |
Hydrolyzes phosphodiester bonds in RNA, poly- and oligoribonucleotides resulting in 3'-nucleoside monophosphates via 2',3'-cyclophosphate intermediates. Ribonuclease Protein, Bacillus amyloliquefaciens, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 13.3 kDa and the accession number is P00648. | |||
TMPH-01602 |
LAMA5 Protein, Human, Recombinant (His & SUMO)
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Human | E. coli |
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. | |||
TMPH-03046 |
TBP1 Protein, MenB, Recombinant (His & Myc)
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MenB | E. coli |
Neisseria acquires iron by extracting it from serum transferrin (TF) in its human host. Acts as a TF receptor and is required for TF utilization. Binds both apo- and holo-TF, via the TF C-terminus. | |||
TMPK-00481 |
PDGF R beta/CD140b Protein, Cynomolgus, Recombinant (His)
PDGF R beta,PDGFRB,PDGFR-2,PDGF-R-β,PDGF-R-beta,PDGFR-β,PDGF... |
Cynomolgus | HEK293 Cells |
Platelet-derived growth factor receptor (PDGFR) signaling is involved in proliferation and survival in a wide array of cell types.PDGFR-β signalling, via TGF-β signalling, may be crucial for restoration of BBB integrity after cerebral ischemia and therefore represents a novel potential therapeutic target. | |||
TMPH-02293 |
UGDH Protein, Human, Recombinant (His & SUMO)
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Human | E. coli |
Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans. Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans. Required for proper brain and neuronal development. | |||
TMPK-00810 |
tPA Protein, Mouse, Recombinant (His)
PLAT,Reteplase,t-PA,tPA,Alteplase |
Mouse | HEK293 Cells |
Tissue plasminogen activator (tPA) is the predominant plasminogen activator present in the vascular and nervous systems.t tPA is not only neuroprotective for postnatal primary cortical neurons, but also that the predominant route for enhancing cell survival is via an mTORdependent mechanism. | |||
TMPK-01221 |
APLN Protein, Mouse, Recombinant (hFc & Avi), Biotinylated
APEL,APJ endogenous ligand,Apelin |
Mouse | HEK293 Cells |
Macrophages play key roles during cardiovascular diseases (CVD) and their related complications.Apelin (APLN) is a key molecule, whose roles during CVD have been documented previously. Therefore, it has been hypothesized that APLN may perform its roles via modulation of macrophages. | |||
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