DMPE-PEG1000 is a PEG lipid functional end group used for liposome (LPs) synthesis, instrumental in designing conjugated polymer nanoparticles. Liposome nanoparticles (LNPs) can undergo further coupling with other biomolecules via biotin modification and carboxyl terminals. These functionalized nanoparticles are applicable for targeted labeling of specific cell proteins. Using streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles can bind to biotinylated antibodies on cell surface receptors, enabling utility in fluorescence-based imaging and sensing.