SUMO2 Protein, Human, Recombinant (His)

Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. SUMO2 can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptidebond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

规格	价格/CNY		数量
10 μg	￥ 60	5日内发货
50 μg	￥ 220	5日内发货
500 μg	￥ 1,540	5日内发货
1 mg	￥ 2,200	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 60

5日内发货

50 μg

￥ 220

5日内发货

500 μg

￥ 1,540

5日内发货

1 mg

￥ 2,200

5日内发货

产品描述

种属	Human
表达系统	E. coli
标签	N-6xHis
蛋白编号	AAH08450.1
别名	HSMT3, Ubiquitin-Like Protein SMT3A, SUMO-3, SMT3A, Sentrin-2, SMT3H2, SUMO-2, Small Ubiquitin-Related Modifier 2, SUMO2, SMT3 homolog 2
氨基酸序列	Met1-Gly93
蛋白构建	Met1-Gly93
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	17 KDa (reducing condition)

内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Small Ubiquitin-Related Modifier 2 (SUMO2) is an Ubiquitin-like protein that belongs to the ubiquitin family with SUMO subfamily. It is a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. SUMO2 can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptidebond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

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复溶计算器

重组蛋白稀释计算器

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Mass (in vial)

Desired Reconstitution Concentration

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SUMO2 Protein, Human, Recombinant (His)

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